Effects of Vitamin D in the Prevention of Acute Viral Bronchiolitis: Systematic Review

Authors

  • Angélica Maria Barba Rueda Pontifícia Universidade Católica do Grande do Sul (PUCRS); Centro Infant, Biomedical Research Institute, PUCRS, Porto Alegre, Brazil
  • Edgar Enrique Sarria-Icaza Medical Course, Universidade de Santa Cruz do Sul, Santa Cruz do Sul.
  • Marcelo Comerlato Scotta Pontifícia Universidade Católica do Grande do Sul (PUCRS); Centro Infant, Biomedical Research Institute, PUCRS, Porto Alegre, Brazil.
  • Leonardo Araújo Pinto Pontifícia Universidade Católica do Grande do Sul (PUCRS); Centro Infant, Biomedical Research Institute, PUCRS, Porto Alegre, Brazil.
  • Ângela de Moura Pontifícia Universidade Católica do Grande do Sul (PUCRS); Centro Infant, Biomedical Research Institute, PUCRS, Porto Alegre, Brazil
  • Rafaela Becker Pontifícia Universidade Católica do Grande do Sul (PUCRS); Centro Infant, Biomedical Research Institute, PUCRS, Porto Alegre, Brazil
  • Matheus Dorigatti Soldatelli Pontifícia Universidade Católica do Grande do Sul (PUCRS); Centro Infant, Biomedical Research Institute, PUCRS, Porto Alegre, Brazil
  • Matias Epifanio Pontifícia Universidade Católica do Grande do Sul (PUCRS); Centro Infant, Biomedical Research Institute, PUCRS, Porto Alegre, Brazil
  • Eduardo Mundstock Pontifícia Universidade Católica do Grande do Sul (PUCRS); Centro Infant, Biomedical Research Institute, PUCRS, Porto Alegre, Brazil
  • Rita Mattiello Pontifícia Universidade Católica do Grande do Sul (PUCRS); Centro Infant, Biomedical Research Institute, PUCRS, Porto Alegre, Brazil

DOI:

https://doi.org/10.15448/1980-6108.2015.2.20313

Keywords:

Vitamin D, Bronchiolitis.

Abstract

Aims: Published evidence suggests that Vitamin D supplementation may have a protective effect on infectious disease of the lower respiratory tract. The objective of this review was to critically appraise the effects of vitamin D intake in the prevention of acute viral bronchiolitis in children.

Methods: We searched the databases MEDLINE, EMBASE, Web of Science, LILACS, and Cochrane Central Register of Controlled Trials, until December 2014. Keywords: "Vitamin D" OR cholecalciferol OR ergocalciferol AND "bronchiolitis, viral" OR bronchiolitides, viral OR "bronchiolitides viral". Eligibility Criteria: We included studies evaluating the effect of vitamin D intake in the prevention of acute viral bronchiolitis in young children. Studies with less than two weeks of intervention and review articles were excluded.

Results: The search identified 241 articles; twenty were selected for full reading but only two were included in the systematic review, comprising 296 children. No study measured serum vitamin D. One of them was a clinical trial, where the number of episodes of acute viral bronchiolitis was significantly lower in children supplemented with vitamin D (Group I: mean: 0.6 ± 0.7 Group II: mean: 1.4 ± 0.9; p = 0.001). The other, a case-control study, did not find a significant relationship between the occurrence of  acute viral bronchiolitis cases and the intake of vitamin D (OR 1.7 95% CI 0.7 to 4.0).

Conclusions: Current scientific evidence is insufficient to prove clinical benefits of vitamin D in preventing  acute viral bronchiolitis.

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References

References

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Published

2015-07-30

How to Cite

Barba Rueda, A. M., Sarria-Icaza, E. E., Comerlato Scotta, M., Araújo Pinto, L., de Moura, Ângela, Becker, R., Dorigatti Soldatelli, M., Epifanio, M., Mundstock, E., & Mattiello, R. (2015). Effects of Vitamin D in the Prevention of Acute Viral Bronchiolitis: Systematic Review. Scientia Medica, 25(2), ID20313. https://doi.org/10.15448/1980-6108.2015.2.20313

Issue

Vol. 25 No. 2 (2015)

Section

Review Articles

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