Epidemiological snapshot of Alzheimer's Disease in Brazi
An analysis of temporal and spatial trends from 2018 to 2023
DOI:
https://doi.org/10.15448/1980-6108.2025.1.47595Keywords:
Alzheimer Disease, epidemiology, population health, public health.Abstract
Aim: Alzheimer’s disease (AD) is a neurodegenerative pathology with a higher prevalence in the elderly. In Brazil, population aging has increased its incidence, requiring a multidisciplinary approach. This study aims to analyze the epidemiological profile of AD and the evolution of hospitalizations between 2018 and 2023. Method: Ecological study of time series using data from the Mortality Information System (SIM) of DATASUS. The analysis included variables such as age group, sex, ethnicity, and regions, using the BioEstat 5.0 and R 4.4.2 software. Statistical significance was determined by p<0.05, and the data were publicly accessed, dispensing with ethical approval. Results: A total of 9,391 hospitalizations for AD were recorded, with a higher prevalence in females (65.95%) and in elderly people aged 80 years or older (59.90%). The mortality rate was 23.82, with a higher incidence of deaths also among the elderly. The Southeast region accounted for most hospitalizations (48.57%) and deaths (58.95%). The increase in AD prevalence reflects global trends, with a greater impact on women and the elderly. Ethnic and regional disparities were observed, with a higher prevalence among whites and significant concentrations of hospitalizations in the Southeast, suggesting inequality in access to care. The increase in hospitalizations between 2022 and 2023 may be related to the COVID-19 pandemic. Conclusion: The study highlighted significant regional and ethnic disparities in Brazil, with a greater
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Menezes CS, Freitas DS, Carvalho GM, Oliveira RC, Almeida SF, Pereira PS. Nursing care for patients with Alzheimer in primary care. RSD. 2024;13(5):e4813545758. https://doi.org/10.33448/rsd-v13i5.45758
Silveira ES, Sousa ER, Santos JF. Importância da fisioterapia no paciente com Alzheimer. Res Soc Dev. 2023;12(13):e91121344184. http://dx.doi.org/10.33448/rsd-v12i13.44184
Abeysinghe AA, Deshapriya RD, Udawatte C. Alzheimer’s disease; a review of the pathophysiological basis and therapeutic interventions. Life Sci. 2020;256(1):117996. https://doi.org/10.1016/j.lfs.2020.117996
Okoti DU, Marinho KK, Marques KKM, Cassa VA, Antunes CM, Andrade HS et al. Doença de Alzheimer: uma análise dos principais sintomas que impactam a qualidade de vida dos pacientes. Rev Contemp. 2024;4(7):e5011. https://doi.org/10.56083/RCV4N7-056
Instituto Brasileiro de Geografia e Estatística (IBGE). Censo Demográfico. Principais resultados [Internet]. Rio de Janeiro: IBGE; 2022 [citado 2025 Jan 26]. Disponível em: https://www.ibge.gov.br/estatisticas/sociais/trabalho/22827-censo-demografico-2022.html
Cabral U. População cresce, mas número de pessoas com menos de 30 anos cai 5,4% de 2012 a 2021 [Internet]. Rio de Janeiro: IBGE; 2022 [citado 2025 Jan 26]. Disponível em: https://agenciadenoticias.ibge.gov.br/agencia-noticias/2012-agencia-de-noticias/noticias/34438-populacao-cresce-mas-numero-de-pessoas-com-menos-de-30-anos-cai-5-4-de-2012-a-2021
Flores LP. O envelhecimento da população brasileira. REDECA. 2015;2(1):86-100. https://doi.org/10.23925/2446-9513.2015v2i1p86-100
Brasil. Ministério da Saúde. Doença de Alzheimer [Internet]. Brasília: Ministério da Saúde; 2025 [citado 2025 Jan 26]. Disponível em: https://www.gov.br/saude/pt-br/assuntos/saude-de-a-a-z/a/alzheimer/alzheimer
Fontenele AR, Cunha KR, Brandão RN, Carreiro LE, Neto ALC, Gonçalves FMS et al. Impactos da Covid-19 na qualidade de vida de pessoas com Alzheimer: uma revisão integrativa. REAS. 2023;23(1):e11563. https://doi.org/10.25248/reas.e11563.2023
Brasil. Ministério da Saúde. Informações de Saúde (TABNET) [Internet]. Brasília: DATASUS; 2025. [citado 2025 Jan 26]. Disponível em: https://datasus.saude.gov.br/informacoes-de-saude-tabnet/
Alzheimer Disease International. World Alzheimer Report 2023: Reducing Dementia Risk: Never too early, never too late. Lincolnshire: Alzheimer Disease International; 2023 [citado 2024 Set 18]. Disponível em: https://www.alzint.org/resource/world-alzheimer-report-2023/
Paschalidis M, Konstantyner TC de O, Simon SS, Martins CB. Tendência de mortalidade por doença de Alzheimer no Brasil, 2000 a 2019. Epidemiol Serv Saúde. 2023;32:e2022886. https://doi.org/10.1590/S2237-96222023000200002
Podcasy JL, Epperson CN. Considering sex and gender in Alzheimer disease and other dementias. Dialogues Clin Neurosci. 2016;18(4):437-46. https://doi.org/10.31887/DCNS.2016.18.4/cepperson
Ferretti MT, Martinkova J, Biskup E, Benke T, Gialdini G, Nedelska Z et al. Sex and gender differences in Alzheimer’s disease: current challenges and implications for clinical practice: Position paper of the Dementia and Cognitive Disorders Panel of the European Academy of Neurology. Eur J Neurol. 2020;27(6):928-43. https://doi.org/10.1111/ene.14174
Chong JR, Ashton NJ, Karikari TK, Tanaka T, Schöll M, Zetterberg H et al. Blood-based high sensitivity measurements of beta-amyloid and phosphorylated tau as biomarkers of Alzheimer’s disease: a focused review on recent advances. J Neurol Neurosurg Psychiatry. 2021;92(11),1231-41. https://doi.org/10.1136/jnnp-2021-327370
Mahaman YA, Embaye KS, Huang F, Li L, Zhu F, Wang JZ et al. Biomarkers used in Alzheimer’s disease diagnosis, treatment, and prevention. Ageing Res Rev. 2022;74:101544. https://doi.org/10.1016/j.arr.2021.101544
Nichols E, Szoeke CEI, Vollset SE, Abbasi N, Abd-Allah F, Abdela J et al. GBD 2016 Dementia Collaborators. Global, regional, and national burden of Alzheimer’s disease and other dementias, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol. 2019;18(1):88-106. https://doi.org/10.1016/S1474-4422(18)30403-4
Neumann LT, Albert SM. Aging in Brazil. Gerontologist. 2018;58(4):611-7. https://doi.org/10.1093/geront/gny019
Lusk JB, Ford C, Clark AG, Greiner MA, Johnson K, Goetz M et al. Racial/ethnic disparities in dementia incidence, outcomes, and health-care utilization. Alzheimers Dement. 2023;19(6):2376-88. https://doi.org/10.1002/alz.12891
Lin PJ, Daly AT, Olchanski N, Cohen JT, Neumann PJ, Faul JD et al. Dementia diagnosis disparities by race and ethnicity. Med Care. 2021;59(8):679-86. https://doi.org/10.1097/mlr.0000000000001577
Albuquerque MV, Viana AL, Lima LD de, Ferreira MP, Fusaro ER, Iozzi FL. Desigualdades regionais na saúde: mudanças observadas no Brasil de 2000 a 2016. Ciênc. Saúde Colet. 2017;22:1055-64. https://doi.org/10.1590/1413-81232017224.26862016
Babulal GM, Zha W, Trani JF, Guerra JL, Tee BL, Zhu Y et al. Identifying Gaps and Barriers in Alzheimer’s Disease and Related Dementia Research and Management in Low-and Middle-Income Countries: A Survey of Health Professionals and Researchers. J Alzheimer’s Dis. 2024;101(4):1307-20. https://doi.org/10.3233/jad-240650
Hunt X, Hameed S, Tetali S, Ngoc LA, Ganle J, Huq L et al. Impacts of the COVID-19 pandemic on access to healthcare among people with disabilities: evidence from six low- and middle-income countries. Int J Equity Health. 2023;22(1):172. https://doi.org/10.1186/s12939-023-01989-1
Knopman DS, Amieva H, Petersen RC, Chételat G, Holtzman DM, Hyman BT et al. Alzheimer disease. Nat Rev Dis Primers. 2021;7(1):1-21. https://doi.org/10.1038/s41572-021-00269-y
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Copyright (c) 2025 Luan Nascimento Pereira de Amorim, Rafael Hendrick Freitas de Paula, Chan David Ribeiro , Bruno Kauê Rodrigues Vilhena , Marcos Lude da Silva Ferreira , Sávio Roberto Silva Costa , Vanessa Novaes Barros , Magda Nery Mauro
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