Epidemiological transition, oxidative stress and chronic non-communicable diseases <b>[Abstract in English]</b>

  • Maria Gabriela Gottlieb PUCRS
  • Alessandra Loureiro Morassutti PUCRS
  • Ivana Mânica da Cruz UFSM
Keywords: OXIDATIVE STRESS, BIOLOGICAL EVOLUTION, CHRONIC DISEASE, EPIDEMIOLOGICAL TRANSITION, HEALTH TRANSITION, DEMOGRAPHIC AGING, HUMANS.

Abstract

Aims: To perform a narrative review on the role of epidemiological transition in the imbalance of oxidative metabolism involved in the etiology of chronic noncommunicable diseases from an evolutionary, environmental and socio-cultural perspective of the Homo sapiens species. Source of data: The sources consulted were Medline, LILACS, and the Brazilian Institute of Geography and Statistics databases. Summary of findings: Several studies have investigated the role of oxidative metabolism in the genesis of chronic non-communicable diseases, suggesting an association between the breakdown of cellular homeostasis and the increased risk for these diseases. Evidence suggests that this breakdown in homeostasis and the emergence of chronic non-communicable diseases has been caused by epidemiological transitions that began in the Neolithic Period, with changes in the ecological relationships between humans, plants, animals and pathogens. These changes led to loss of diversity of food, sedentary lifestyle and pollution, by creating disturbances in cellular redox balance, and increased incidence of chronic non-communicable diseases. Conclusions: Changes along the human evolutionary history affected the cellular metabolism by promoting the onset of chronic non-communicable diseases. Therefore it is essential to understand how these changes occurred and their pathophysiological impact in the body, for identifying individuals who are more susceptible to develop chronic non-communicable diseases, and to build action plans for prevention.

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Author Biographies

Maria Gabriela Gottlieb, PUCRS
Butrigenética, ciências da saúde
Alessandra Loureiro Morassutti, PUCRS
Bióloga. Doutoranda do Programa de Pós Graduação em Zoologia da PUCRS. Laboratório de Parasitologia.
Ivana Mânica da Cruz, UFSM
Bióloga. Doutor em Genética e Biologia Molecular. Programa de Pós Graduação em Bioquímica Toxicológica e Programa de Pós Graduação em Farmacologia da Universidade Federal de Santa Maria. Departamento de Ciências da Saúde
Published
2011-07-01
How to Cite
Gottlieb, M. G., Morassutti, A. L., & da Cruz, I. M. (2011). Epidemiological transition, oxidative stress and chronic non-communicable diseases <b>[Abstract in English]</b>. Scientia Medica, 21(2), 69-80. Retrieved from https://revistaseletronicas.pucrs.br/ojs/index.php/scientiamedica/article/view/8712
Section
Review Articles