Potentially inappropriate medication and associated factors such as depression and dementia: An analysis of middle-aged and elderly people

Keywords: potentially inappropriate medication list, middle aged, aged, depression, dementia, public health

Abstract

AIMS: To establish the frequency potentially inappropriate medications use and the associated factors, such as signs and symptoms of depression and cognitive deficit among middle-aged and elderly people.
METHODS: A cross-sectional population study was performed with 2,350 people, aged between 55-103 years, registered in the primary health care. Potentially inappropriate medications were defined by updated 2019 Beers criteria. Studied variables were sociodemographic, lifestyle and health, and signs and symptoms of depression and cognitive deficit. Multinomial regression analysis was executed.
RESULTS: The frequency of potentially inappropriate medications use was 65.4%. Former and current smokers, regular self-perception of health, polypharmacy, and individuals with signs and symptoms of depression and cognitive deficit were significantly associated with potentially inappropriate medications use. Antiarrhythmics, antihistamines and antiadrenergic agents were the highest potentially inappropriate medications classes used for individuals with signs and symptoms of depression and cognitive deficit.
CONCLUSIONS: The frequency of use of potentially inappropriate medications is high among middle-aged people, a population that was previously under-researched, as well as among elderly people. Cognitive impairment alone or together with depression symptoms were associated factor for a potentially inappropriate medications use. Knowledge of the pharmacoepidemiology of potentially inappropriate medications is an important for the promotion of the rational use of drugs in public health.

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Author Biographies

Vanessa Sgnaolin, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Graduate Program in Biomedical Gerontology. Porto Alegre, RS

Pharmacist, Specialist in Health with emphasis on Clinical and Toxicological Analysis, MD in Health Sciences and PhD in Biomedical Gerontology. Postdoctoral student of the Graduate Program in Biomedical Gerontology at Pontifical Catholic University of Rio Grande do Sul (PUCRS).

Paula Engroff, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Institute of Geriatrics and Gerontology. Porto Alegre, RS

Pharmacist, Specialist in Teaching in Higher Education and PhD in Biomedical Gerontology. Pharmacist at the Biochemistry and Molecular Genetics Laboratory of the Institute of Geriatrics and Gerontology at Pontifical Catholic University of Rio Grande do Sul (PUCRS).

Natascha Melo Linkievicz, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), School of Health and Life Sciences. Porto Alegre, RS

Pharmacy Student at Pontifical Catholic University of Rio Grande do Sul (PUCRS). Scientific Initiation Scholarship at the Biochemistry and Molecular Genetics Laboratory of the Graduate Program in Biomedical Gerontology at PUCRS.

Irenio Gomes, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Graduate Program in Biomedical Gerontology. Porto Alegre, RS

Physician, MD in Cellular and Molecular Biology, PhD in Medicine and Postdoctoral at Hôpital de Bicêtre in Paris.

Alfredo Cataldo Neto, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), School of Medicine and Graduate Program in Biomedical Gerontology. Porto Alegre, RS

Physician, Specialist in Psychiatry, Psychoanalyst and PhD in Clinical Medicine. Professor of School of Medicine at Pontifical Catholic University of Rio Grande do Sul (PUCRS) and researcher at the PUCRS Institute of Geriatrics and Gerontology.

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Published
2020-07-15
How to Cite
Sgnaolin, V., Engroff, P., Melo Linkievicz, N., Gomes, I., & Cataldo Neto, A. (2020). Potentially inappropriate medication and associated factors such as depression and dementia: An analysis of middle-aged and elderly people. Scientia Medica, 30(1), e34478. https://doi.org/10.15448/1980-6108.2020.1.34478
Section
Original Articles