Sarcoma fibromixoide de baixo grau em região paratesticular
Um relato de caso
DOI:
https://doi.org/10.15448/1980-6108.2022.1.43540Palavras-chave:
sarcoma, patologia, urologiaResumo
Objetivos: relatar um caso raro de sarcoma fibromixoide de baixo grau (SFMBG) em uma localização incomum de modo a reforçar aspectos histopatológicos e imunoistoquímicos relevantes para o reconhecimento desta entidade e o adequado diagnóstico diferencial de massas paratesticulares.
Relato de caso: homem de 20 anos, com massa escrotal à direita, cuja análise histopatológica demonstrou a presença de tecido fibroso com áreas mixoides e predominância de células fusiformes. A imunoistoquímica foi positiva para vimentina, com índice de Ki67 de 2%, e negativa para S100, CD-34, beta-catenina, desmina e miogenina.
Conclusões: caso raro de SFMBG na região paratesticular que reforça a importância da histopatologia e da imunoistoquímica no diagnóstico desse tumor. Apesar da característica histológica benigna, o SFMBG apresenta altas taxas de recorrência e metástases, sendo essencial o seguimento do paciente.
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Unlü Y, Huq GE, Ozyalvaçli G, et al. Paratesticular sarcomas: a report of seven cases. Oncol Lett. 2015;9(1):308-12. https://doi.org/10.3892/ol.2014.2629 DOI: https://doi.org/10.3892/ol.2014.2629
Smith ZL, Werntz RP, Eggener SE. Testicular Cancer: Epidemiology, Diagnosis, and Management. Med Clin North Am. 2018;102(2):251-64. https://doi.org/10.1016/j.mcna.2017.10.003 DOI: https://doi.org/10.1016/j.mcna.2017.10.003
Soosay GN, Parkinson MC, Paradinas J, Fisher C. Paratesticular sarcomas revisited: a review of cases in the British Testicular Tumour Panel and Registry. Br J Urol. 1996;77(1):143-6. https://doi.org/10.1046/j.1464-410x.1996.84925.x DOI: https://doi.org/10.1046/j.1464-410X.1996.84925.x
Mohamed M, Fisher C, Thway K. Low-grade fibromyxoid sarcoma: Clinical, morphologic and genetic features. Ann Diagn Pathol. 2017;28:60-7. https://doi.org/10.1016/j.anndiagpath.2017.04.001 DOI: https://doi.org/10.1016/j.anndiagpath.2017.04.001
Evans HL. Low-grade fibromyxoid sarcoma. A report of two metastasizing neoplasms having a deceptively benign appearance. Am J Clin Pathol. 1987;88(5):615-9. https://doi.org/10.1093/ajcp/88.5.615 DOI: https://doi.org/10.1093/ajcp/88.5.615
Lane KL, Shannon RJ, Weiss SW. Hyalinizing spindle cell tumor with giant rosettes: a distinctive tumor closely resembling low-grade fibromyxoid sarcoma. Am J Surg Pathol. 1997;21(12):1481-8. https://doi.org/10.1097/00000478-199712000-00011 DOI: https://doi.org/10.1097/00000478-199712000-00011
Rekhi B, Deshmukh M, Jambhekar NA. Low-grade fibromyxoid sarcoma: a clinicopathologic study of 18 cases, including histopathologic relationship with sclerosing epithelioid fibrosarcoma in a subset of cases. Ann Diagn Pathol. 2011;15(5):303-11. https://doi.org/10.1016/j.anndiagpath.2011.02.005 DOI: https://doi.org/10.1016/j.anndiagpath.2011.02.005
Kurisaki-Arakawa A, Suehara Y, Arakawa A, et al. Deeply located low-grade fibromyxoid sarcoma with FUS-CREB3L2 gene fusion in a 5-year-old boy with review of literature. Diagn Pathol. 2014;9:163. https://doi.org/10.1186/s13000-014-0163-2 DOI: https://doi.org/10.1186/s13000-014-0163-2
Billings SD, Giblen G, Fanburg-Smith JC. Superficial low-grade fibromyxoid sarcoma (Evans tumor): a clinicopathologic analysis of 19 cases with a unique observation in the pediatric population. Am J Surg Pathol. 2005;29(2):204-10. https://doi.org/10.1097/01.pas.0000146014.22624.8e DOI: https://doi.org/10.1097/01.pas.0000146014.22624.8e
Abe Y, Hashimoto I, Nakanishi H. Recurring facial low-grade fibromyxoid sarcoma in an elderly patient: a case report. J Med Invest. 2012;59(3-4):266-9. https://doi.org/10.2152/jmi.59.266 DOI: https://doi.org/10.2152/jmi.59.266
Mendoza AS, O’Leary MP, Peng S-K, Petrie BA, Li AI, French SW. Low-grade fibromyxoid sarcoma of the sigmoid colon. Exp Mol Pathol. 2015;98(2):300-3. https://doi.org/10.1016/j.yexmp.2015.02.007 DOI: https://doi.org/10.1016/j.yexmp.2015.02.007
Alevizopoulos A, Mygdalis V, Tyritzis S, Stravodimos K, Constantinides CA. Low-grade fibromyxoid sarcoma of the renal pelvis: first report. Case Rep Nephrol Urol. 2012;2(2):87-91. https://doi.org/10.1159/000341191 DOI: https://doi.org/10.1159/000341191
Evans HL. Low-grade fibromyxoid sarcoma: a clinicopathologic study of 33 cases with long-term follow-up. Am J Surg Pathol. 2011;35(10):1450-62. https://doi.org/10.1097/PAS.0b013e31822b3687 DOI: https://doi.org/10.1097/PAS.0b013e31822b3687
Baspinar S, Kapucuoglu N, Akdeniz R, Oksay T, Guzel A, Kocer M. Paratesticular myxofibrosarcoma. Indian J Pathol Microbiol. 2014;57(3):503-4. https://doi.org/10.4103/0377-4929.138805 DOI: https://doi.org/10.4103/0377-4929.138805
Raza A, Ankur, Ashutosh, Ranjan. Paratesticular sarcoma mimicking as left sided traumatic hematocele: a case report. J Evol Med Dent Sci. 2015;4(70):12262-6. https://doi.org/10.14260/jemds/2015/1769 DOI: https://doi.org/10.14260/jemds/2015/1769
Wu X, Petrovic V, Torode IP, Chow CW. Low grade fibromyxoid sarcoma: problems in the diagnosis and management of a malignant tumour with bland histological appearance. Pathology. 2009;41(2):155-60. https://doi.org/10.1080/00313020802579276 DOI: https://doi.org/10.1080/00313020802579276
Khoubehi B, Mishra V, Ali M, Motiwala H, Karim O. Adult paratesticular tumours. BJU Int. 2002;90(7):707-15. doi:10.1046/j.1464-410x.2002.02992.x DOI: https://doi.org/10.1046/j.1464-410X.2002.02992.x
Ozkan B, Ozgüroğlu M, Ozkara H, Durak H, Talat Z. Adult paratesticular myxofibrosarcoma: report of a rare entity and review of the literature. Int Urol Nephrol. 2006;38(1):5-7. https://doi.org/10.1007/s11255-005-0255-8 DOI: https://doi.org/10.1007/s11255-005-0255-8
Doyle LA, Möller E, Dal Cin P, Fletcher CDM, Mertens F, Hornick JL. MUC4 is a highly sensitive and specific marker for low-grade fibromyxoid sarcoma. Am J Surg Pathol. 2011;35(5):733-41. https://doi.org/10.1097/PAS.0b013e318210c268 DOI: https://doi.org/10.1097/PAS.0b013e318210c268
Mastoraki A, Strigkos T, Tatakis F-P, Christophi A, Smyrniotis V. Recurrent Low-Grade Fibromyxoid Sarcoma of the Neck: Report of a Case and Review of the Literature. Indian J Surg Oncol. 2015;6(3):296-9. https://doi.org/10.1007/s13193-015-0429-5 DOI: https://doi.org/10.1007/s13193-015-0429-5
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