Aspectos oxidativos da síndrome metabólica e aterosclerose

Autores

  • Sandra Maria Barbalho Faculdade de Medicina de Marília - UNIMAR e FATEC - Marília
  • Karina Quesada Departamento de Bioquímica e Biologia Celular da Universidade de Marília - UNIMAR, Marília, SP, Brasil.
  • Ricardo de Alvares Goulart Médico da Associação Beneficente Hospital Universitário (ABHU). E-mail: ricardogoulartmed@hotmail.com
  • Marcelo Dib Bechara Departamento de Bioquímica e Biologia Celular da Universidade de Marília - UNIMAR, Marília, SP, Brasil. E-mail: dib.marcelo1@gmail.com
  • Márcia Rocha Gabaldi Departamento de Bioquímica e Biologia Celular da Universidade de Marília - UNIMAR, Marília, SP, Brasil. E-mail: marciagabaldi@gmail.com
  • Gabriela L. dos Santos Almeida Graduanda em Medicina pela Faculdade de Medicina da Universidade de Mogi das Cruzes AB de Cândido Xavier de Almeida e Souza. E-mail: gabi.lombardi88@hotmail.com
  • Rodrigo Galhardi Gasparini Médico da Associação Beneficente Hospital Universitário (ABHU). Mestrando em Bases Gerais da Cirurgia pela UNESP - Universidade Estadual Paulista “Julio de Mesquita Filho”, campus Botucatu-SP, Brasil. E-mail: rodgaspa@yahoo.com.br

DOI:

https://doi.org/10.15448/1980-6108.2015.3.21092

Palavras-chave:

síndrome x metabólica, estresse oxidativo, aterosclerose.

Resumo

Objetivos: Realizar uma revisão da literatura sobre os aspectos que envolvem o estresse oxidativo e seu papel na síndrome metabólica e na aterosclerose.

Métodos: A pesquisa foi realizada em abril e maio de 2015, utilizando as bases de dados PubMed, SciELO e LILACS e compreendendo as publicações a partir de 2011. Para a busca dos artigos foram utilizados os seguintes descritores: ((oxidative stress) AND (atherosclerosis OR metabolic syndrome)). Foram selecionados preferencialmente metanálises e ensaios clínicos contendo grande tamanho amostral.

Resultados: Estavam disponíveis 3934 artigos nas bases de dados ao buscar o período e os descritores informados (PubMed 3292, Scielo 588, Lilacs 54).  Após eliminadas as referências duplas e aplicados os critérios de inclusão, foram selecionados 53 artigos para esta revisão.

Conclusões: As alterações bioquímicas e antropométricas características da síndrome metabólica relacionam-se a processos inflamatórios e ao estresse oxidativo, que por sua vez estão diretamente relacionados à aterosclerose. Uma melhor compreensão de como as condições que definem a síndrome metabólica favorecem o estresse oxidativo pode contribuir de forma significativa para futuras abordagens ao paciente com doença cardiovascular.

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Publicado

2015-11-17

Como Citar

Barbalho, S. M., Quesada, K., Goulart, R. de A., Bechara, M. D., Gabaldi, M. R., Almeida, G. L. dos S., & Gasparini, R. G. (2015). Aspectos oxidativos da síndrome metabólica e aterosclerose. Scientia Medica, 25(3), ID21092. https://doi.org/10.15448/1980-6108.2015.3.21092

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