Epidemiological dynamics at the peak of the COVID-19 pandemic among children in Rio Grande do Sul, Brazil

Authors

DOI:

https://doi.org/10.15448/1980-6108.2024.1.46010

Keywords:

COVID-19, SARS-CoV-2., Children, severe acute respiratory syndrome, Epidemiology

Abstract

Objective: to describe the profile of children infected by SARS-CoV-2 in Rio Grande do Sul, Brazil, between March 1, 2020, and April 30, 2021, comparing infection rates and disease evolution stratified by age group. Methods: this cross-sectional study used data from COVID-19-confirmed cases from a public state database in children aged zero–nine. Results: the study sample comprised 35,131 children. We found the highest infection rate in the age group of zero–four years old, 3.8% (95%CI:3.3%-4.3%). Of the patients, 3.8% (n = 1,323) had comorbidities, the most prevalent being respiratory tract disease (56.2%, n=829). 450 (1.3%) children developed Severe Acute Respiratory Syndrome (SARS), with a lethality rate of 0.05% (95%CI:0.02%-0.08%). However, we found that both outcomes decreased when age increased; thus, a PR of 8.68 (CI95%:6.86-10.99) was estimated for SARS and PR=5,52 (CI95%:1,26- 24,09) for death in the presence of respiratory comorbidity. Discussion: this study revealed a low mortality rate in this population. The presence of respiratory comorbidities increases the risk of SARS and death. Both outcomes increased in younger age groups.

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Author Biographies

Débora Miotto Lorenzetti , University of Passo Fundo (UPF), Medical School, Passo Fundo, RS, Brazil.

Medical student at the University of Passo Fundo (UPF), in Passo Fundo, RS, Brazil.

Luiza Souza , University of Passo Fundo (UPF), Medical School, Passo Fundo, RS, Brazil.

Medical student at the University of Passo Fundo (UPF), in Passo Fundo, RS, Brazil.

Natália de Oliveira Godoy , University of Passo Fundo (UPF), Medical School, Passo Fundo, RS, Brazil.

Medical student at the University of Passo Fundo (UPF), in Passo Fundo, RS, Brazil.

Giovanni Gosch Berton , University of Passo Fundo (UPF), Medical School, Passo Fundo, RS, Brazil.

Medical student at the University of Passo Fundo (UPF), in Passo Fundo, RS, Brazil.

Cristiane Barelli , University of Passo Fundo (UPF), Medical School, Passo Fundo, RS, Brazil.

PhD in Letters from the University of Passo Fundo, in Passo Fundo, RS, Brazil; Post-doctorate at the Federal University of São Paulo (UNIFESP), in São Paulo, SP, Brazil. Professor at the University of Passo Fundo (UPF), in Passo Fundo, RS, Brazil.

Gilberto da Luz Barbosa , University of Passo Fundo (UPF), Medical School, Passo Fundo, RS, Brazil.

MSc in Medical Sciences from the Federal University of Rio Grande do Sul (UFRGS), in Porto Alegre, RS, Brazil. Professor at the University of Passo Fundo (UPF), in Passo Fundo, RS, Brazil.

Julcemar Bruno Zilli , University of Passo Fundo (UPF), School of Agricultural Sciences, Innovation, and Business, Passo Fundo, RS, Brazil.

PhD in Sciences from the Escola Superior de Agricultura Luiz de Queiroz, University of São Paulo (USP), in Piracicaba, SP, Brazil. Professor at the University of Passo Fundo (UPF), in Passo Fundo, RS, Brazil.

Daniela Bertol Graeff, University of Passo Fundo (UPF), Medical School, Passo Fundo, RS, Brazil.

MSc in Epidemiology from the Federal University of Rio Grande do Sul (UFRGS), in Porto Alegre, RS, Brazil. Professor at the University of Passo Fundo (UPF), in Passo Fundo, RS, Brazil.

References

National Center for Immunization and Respiratory Diseases (NCIRD), Division of Viral Diseases. CDC COVID-19 science briefs [Internet]. Atlanta (GA): Centers for Disease Control and Prevention (US); 2020 [cited 2024 Jul 31]. Science brief: transmission of SARS-CoV-2 in K-12 schools and early care and education programs; [updated 2021 Dec 17]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK570438

Qiu H, Wu J, Hong L, Luo Y, Song Q, Chen D. Clinical and epidemiological features of 36 children with coronavirus disease 2019 (COVID-19) in Zhejiang, China: an observational cohort study. Lancet Infect Dis. 2020;20(6):689-96. https://doi.org/10.1016/S1473-3099(20)30198-5 DOI: https://doi.org/10.1016/S1473-3099(20)30198-5

Dawood FS, Porucznik CA, Veguilla V, Stanford JB, Duque J, Rolfes MA, et al. Incidence rates, household infection risk, and clinical characteristics of SARS-CoV-2 infection among children and adults in Utah and New York City, New York. JAMA Pediatr. 2022;176(1):59-67. https://doi.org/10.1001/jamapediatrics.2021.4217 DOI: https://doi.org/10.1001/jamapediatrics.2021.4217

Pinto R, Borges I, Amorim J. Change in the epidemiological profile of severe acute respiratory syndrome in the Brazilian pediatric population: indication of COVID-19 subnotification. Resid Pediatr.[Internet]. 2020 [cited 2024 jul 31];10(3):1-6. Available from: https://cdn.publisher.gn1.link/residenciapediatrica.com.br/pdf/en_rp091221a08.pdf DOI: https://doi.org/10.25060/residpediatr-2020.v10n3-407

Liguoro I, Pilotto C, Bonanni M, Ferrari ME, Pusiol A, Nocerino A, et al. SARS-COV-2 infection in children and newborns: a systematic review. Eur J Pediatr. 2020;179(7):1029-46. https://doi.org/10.1007/s00431-020-03684-7 DOI: https://doi.org/10.1007/s00431-020-03684-7

Teich VD, Klajner S, Almeida AS, Dantas CB, Laselva CR, Torritesi MG, et al. Epidemiologic and clinical features of patients with COVID-19 in Brazil. Einstein (São Paulo). 2020;18:eAO6022. https://doi.org/10.31744/einstein_journal/2020AO6022 DOI: https://doi.org/10.31744/einstein_journal/2020AO6022

Deville JG, Song E, Ouellette CP. COVID-19: Management in children. In: UpToDate, Edwards MS, Blake D, editors [Internet]. Waltham, MA: UpToDate Inc.; 2024 Jul 25 [cited 2024 Aug 7]. Available from: https://www.uptodate.com/contents/covid-19-clinical-manifestations-and-diagnosis-in-children?search=COVID-19%3A%20Manejo%20em%20crian%C3%A7as%20Deville%2C%20JG&source=search_result&selectedTitle=1%7E150&usage_type=default&display_rank=1

Rio Grande do Sul, Secretaria Estadual da Saúde. Painel Coronavírus RS [Internet]. Porto Alegre: Secretaria da Saúde do Estado do Rio Grande do Sul; 2020 [cited 2022 Mar 11]. Available from: https://ti.saude.rs.gov.br/covid19

Rio Grande do Sul, Secretaria Estadual da Saúde. Estado inicia a distribuição de vacina contra covid-19 para crianças de 6 meses a 2 anos [Internet]. Porto Alegre: Secretaria da Saúde do Estado do Rio Grande do Sul; 2022 Nov 11 [cited 2024 Jul 08]; Notícias:[about 2 screens] . Available from: https://saude.rs.gov.br/estado-inicia-a-distribuicao-de-vacina-contra-a-covid-19-para-criancas-de-6-meses-a-2-anos

Brasil, Ministério da Saúde. Conselho Nacional de Saúde. Resolução nº 510, de 07 de abril de 2016. Dispõe sobre a Pesquisa em Ciências Humanas e Sociais. Diário Oficial da União [Internet]. Brasília: Presidência da República; 2016 Maio 24 [cited 2022 Apr 22];98(seção 1):44-6. Available from: https://conselho.saude.gov.br/images/comissoes/conep/documentos/NORMAS-RESOLUCOES/Resoluo_n_510_-_2016_-_Ciencias_Humanas_e_Sociais.pdf

Brasil, Instituto Brasileiro de Geografia e Estatística. Rio Grande do Sul. Cidades e Estados [Internet]. Rio de Janeiro: IBGE; 2022 [cited 2022 May 31]. Available from: https://www.ibge.gov.br/cidades-e-estados/rs

Rio Grande do Sul, Secretaria Estadual da Saúde, Centro Estadual de Vigilância em Saúde. Boletim epidemiológico Covid-2019. Centro de Operações de Emergência do Rio Grande do Sul. Semana Epidemiológica 45 de 2021 [Internet]. Porto Alegre: COERS; 2021 [cited 2024 Jul 17]. Available from: https://coronavirus.rs.gov.br/upload/arquivos/202111/27110755-boletim-epidemiologico-covid-19-coers-se-45.pdf

Brasil, Ministério da Saúde. DATASUS: Informações de Saúde (Tabnet) [Internet]. Brasília, DF: Ministério da Saúde; 2022 [cited 2022 May 31]. Available from: https://datasus.saude.gov.br/populacao-residente

Brasil, Ministério da Saúde, Secretaria de Vigilância em Saúde, Departamento de Articulação Estratégica de Vigilância em Saúde. Guia de Vigilância em Saúde: 5ª edição revisada e atualizada [Internet]. Brasília (DF): Ministério da Saúde; 2022 [cited 2024 Jul 17]. Available from: https://www.gov.br/saude/pt-br/centrais-de-conteudo/publicacoes/svsa/vigilancia/guia-de-vigilancia-em-saude-5a-edicao-revisada-e-atualizada-2022/view

Andrade M, Lamounier J, Paiva T, Leite P, Silva E. Lethality by COVID-19 in children: an integrative review. Residência Pediátrica. 2021;11(1). Available from: https://cdn.publisher.gn1.link/residenciapediatrica.com.br/pdf/rp100821a04.pdf DOI: https://doi.org/10.25060/residpediatr-2021.v11n1-421

Silva JRA, Argentino ACA, Dulaba LD, Bernardelli RR, Campiolo EL. COVID-19 em pediatria: um panorama entre incidência e mortalidade. Resid Pediatr. 2020;10(3):7-10.

Swann OV, Holden KA, Turtle L, Pollock L, Fairfield CJ, Drake TM, et al. Clinical characteristics of children and young people admitted to hospital with COVID-19 in the United Kingdom: prospective multicentre observational cohort study. BMJ. 2020;370:rm3249. https://doi.org/10.1136/bmj.m3249 DOI: https://doi.org/10.1136/bmj.m3249

Su L, Ma X, Yu H, Zhang Z, Bian P, Han Y, et al. The different clinical characteristics of corona virus disease cases between children and their families in China – the character of children with COVID-19. Emerg Microbes Infect [Internet]. 2020;9(1):707. https://doi.org/10.1080/22221751.2020.1744483 DOI: https://doi.org/10.1080/22221751.2020.1744483

Brasil, Instituto Brasileiro de Geografia e Estatística. Síntese de Indicadores Sociais [Internet]. Rio de Janeiro: IBGE; 2023 [cited 2024 Jul 29]. Available from: https://www.ibge.gov.br/estatisticas/sociais/trabalho/9221-sintese-de-indicadores-sociais.html

Blanco F, Bernardino S, Roberto G, Castilho DC. Perfil epidemiológico de crianças e adolescentes com COVID-19 : uma revisão de escopo. Rev Brasl Enferm [Internet]. 2021;74(Suppl 1):e20200624. https://doi.org/10.1590/0034-7167-2020-0624 DOI: https://doi.org/10.1590/0034-7167-2020-0624

Cestari VRF, Florêncio RS, Sousa GJB, Garces TS, Maranhão TA, Castro RR, et al. Social vulnerability and COVID-19 incidence in a brazilian metropolis. Ciênc saude coletiva. 2021;26(3):1023-33. https://doi.org/10.1590/1413-81232021263.42372020 DOI: https://doi.org/10.1590/1413-81232021263.42372020

Gomes NT, Haslett MI, Alves AJ, Percio J, Duarte MM, Malta JM, et al. Coorte retrospectiva de crianças e adolescentes hospitalizados por COVID-19 no Brasil do início da pandemia a 1o de agosto de 2020. Rev Bras Epidemiol. 2021;24:e210026. https://doi.org/10.1590/1980-549720200026 DOI: https://doi.org/10.1590/1980-549720200026

Cavalcante ANM, Tavares LVS, Bastos MLA, Almeida RLF. Clinical-epidemiological profile of children and adolescents with COVID-19 in ceará. Rev Bras Saude Matern Infant. 2021;21:429-35. https://doi.org/10.1590/1806-9304202100S200006 DOI: https://doi.org/10.1590/1806-9304202100s200006

Santos AO, Lucarevschi BR, Bajeri MH, Pires LO, Ubriaco DC, Nascimento LFC. Infecção pelo SARS-CoV-2 em crianças e adolescentes: uma experiência brasileira. Rev paul pediatr. 2022;40(e2021172). https://doi.org/10.1590/1984-0462/2022/40/2021172IN DOI: https://doi.org/10.1590/1984-0462/2022/40/2021172in

Maciel ELN, Gomes CC, Almada GL, Medeiros Junior NF, Cardoso OA, Jabor PM, et al. COVID-19 in children, adolescents and young adults: a cross-sectional study in Espírito Santo, Brazil, 2020. Epidemiol Serv Saude. 2021;30(4):e20201029. https://doi.org/10.1590/S1679-49742021000400001 DOI: https://doi.org/10.1590/s1679-49742021000400001

Prata‐Barbosa A, Lima‐Setta F, Santos GR, Lanziotti VS, Castro REV, Souza DC, et al. Pediatric patients with COVID‐19 admitted to intensive care units in Brazil: a prospective multicenter study. J Pediatr [Rio J]. 2020;96(5):582-92. https://doi.org/10.1016/j.jped.2020.07.002 https://doi.org/10.1016/j.jped.2020.07.002 DOI: https://doi.org/10.1016/j.jped.2020.07.002

Barbosa GL, Graeff D, Oliveira E, Barelli C, Lorenzetti D, Souza L, Godoy NZ. Associação entre comorbidades, síndrome respiratória aguda grave (SRAG) e óbito em crianças com diagnóstico de COVID-19. Braz J Infect Dis. 2022;26(S1):102010. https://doi.org/10.1016/j.bjid.2021.102010 DOI: https://doi.org/10.1016/j.bjid.2021.102010

González DA, Victora CG, Gonçalves H. Efeitos das condições climáticas no trimestre de nascimento sobre asma e pneumonia na infância e na vida adulta em uma coorte no Sul do Brasil. Cad Saude Publica. 2008;24(5):1089-102. https://doi.org/10.1590/S0102-311X2008000500016 DOI: https://doi.org/10.1590/S0102-311X2008000500016

Brasil, Ministério da Saúde, Secretaria de Vigilância em Saúde. Guia de vigilância epidemiológica: Emergência de saúde pública de importância nacional pela doença pelo coronavírus 2019 [Internet]. Brasília (DF): Ministério da Saúde; 2022 [cited 2024 Fev 22]. Available from: https://www.gov.br/saude/pt-br/assuntos/covid-19/publicacoes-tecnicas/guias-e-planos/guia-de-vigilancia-epidemiologica-covid-19/view

Niquini RP, Lana RM, Pacheco AG, Cruz OG, Coelho FC, Carvalho LM, et al. Description and comparison of demographic characteristics and comorbidities in SARI from COVID-19, SARI from influenza, and the Brazilian general population. Cad Saude Publica. 2020;36(7):e00149420. https://doi.org/10.1590/0102-311X00149420 DOI: https://doi.org/10.1590/0102-311x00149420

Bhopal S, Bagaria J, Bhopal R. Children’s mortality from COVID-19 compared with all-deaths and other relevant causes of death: epidemiological information for decision-making by parents, teachers, clinicians, and policymakers. Public Health. 2020;185:19-20. https://doi.org/10.1016/j.puhe.2020.05.047 DOI: https://doi.org/10.1016/j.puhe.2020.05.047

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Published

2024-11-25

How to Cite

Miotto Lorenzetti , D., Souza , L., de Oliveira Godoy , N., Gosch Berton , G., Barelli , C., da Luz Barbosa , G., … Bertol Graeff, D. (2024). Epidemiological dynamics at the peak of the COVID-19 pandemic among children in Rio Grande do Sul, Brazil. Scientia Medica, 34(1), e46010. https://doi.org/10.15448/1980-6108.2024.1.46010

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