Cyanobacteria for Cardiomyocyte Protection against miocardial ischemia injury
a systematic review of animal and in vitro studies
DOI:
https://doi.org/10.15448/1980-6108.2024.1.44970Keywords:
cyanobacteria, spirulina, ischemia, cardiovascular diseases.Abstract
Objective: To perform a systematic review on using Cyanobacteria for protecting the cardiac tissue against damage caused by ischemia.
Methods: this review encompasses in vitro and controlled animal experimental studies.
Results: the results show that in general there are two types of interventions for treatment of ischemia and Ischemia/Reperfusion (IR) in cardiac tissue: (1) extracts treatments and (2) injection of Cyanobacteria in the damaged tissues. Extract treatments are based on the antioxidant potential of Cyanobacteria, and the studies focus mainly on Spirulina (Arthrospira platensis). The direct injection methods are based on the high capacity of these organisms to release oxygen during photosynthesis. Synechococcus elongatus is the Cyanobacteria species most commonly utilized in injections, either delivered independently or carried by hydrogels or nanoparticles. The direct Cyanobacteria injections are innovative techniques which can promote protection against apoptosis and have shown promising results, however, further research is necessary to refine the techniques and improve overall efficacy.
Conclusion: the effects of these treatments were beneficial considering that the antioxidant effects of Cyanobacteria ameliorate blood biochemical markers and reduce damaged cardiac areas. The oxygen releasing of Cyanobacteria in the cardiac tissue also promoted recovery of cardiac tissue after ischemia or IR.
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Kumar V, Abbas AK, Aster JC. Robbins Basic Pathology. 10th ed. Elsevier; 2017. 952 p.
Sarı E, Dilli D, Taşoğlu İ, Akduman H, Yumuşak N, Tümer NB, et al. Protective role of melatonin and spirulina in aortic occlusion-reperfusion model in rats. J Food Biochem. 2022 Apr 1;46(4). DOI: https://doi.org/10.1111/jfbc.13926
Tang PS, Mura M, Seth R, Liu M. Acute lung injury and cell death: how many ways can cells die? Am J Physiol Lung Cell Mol Physiol [Internet]. 2008;294:632–41. Available from: www.ajplung.org DOI: https://doi.org/10.1152/ajplung.00262.2007
Zhu Y, Woo YJ. Photosynthetic symbiotic therapeutics – An innovative, effective treatment for ischemic cardiovascular diseases. J Mol Cell Cardiol. 2022 Mar 1;164:51–7. DOI: https://doi.org/10.1016/j.yjmcc.2021.11.007
WHO. https://www.who.int/health-topics/cardiovascular-diseases#tab=tab_1. Accessed 29 June 2023. 2023. Cardiovascular diseases.
Gao J, Zhao L, Wang J, Zhang L, Zhou D, Qu J, et al. C-phycocyanin ameliorates mitochondrial fission and fusion dynamics in ischemic cardiomyocyte damage. Front Pharmacol. 2019;10(JUN). DOI: https://doi.org/10.3389/fphar.2019.00733
Mirmiran P, Hosseini-Esfahani F, Esfandiar Z, Hosseinpour-Niazi S, Azizi F. Associations between dietary antioxidant intakes and cardiovascular disease. Sci Rep. 2022 Dec 1;12(1). DOI: https://doi.org/10.1038/s41598-022-05632-x
Zhang Y, Liu S, Ma JL, Chem C, Huang P, Ji JH, et al. Apocynum venetum leaf extract alleviated doxorubicin-induced cardiotoxicity through the AKT/Bcl-2 signaling pathway. Phytomedicine. 2022;94:153815. DOI: https://doi.org/10.1016/j.phymed.2021.153815
Lopes G, Silva M, Vasconcelos V. The Pharmacological Potential of Cyanobacteria. London: Academic Press; 2022. 356 p.
Li Y. The Bioactivities of Phycocyanobilin from Spirulina. J Immunol Res. 2022;4008991. DOI: https://doi.org/10.1155/2022/4008991
United Nations. https://digitallibrary.un.org/record/560424?ln=en. Accessed in 29 June 2023. 2005. p. 2 The use of spirulina to combat hunger and malnutrition to help achieve sustainable development : revised draft resolution / Burundi, Cameroon, Dominican Republic, Nicaragua and Paraguay.
Pappas A, Tsiokanos A, Fatouros IG, Poulios A, Kouretas D, Goutzourelas N, et al. The effects of spirulina supplementation on redox status and performance following a muscle damaging protocol. Int J Mol Sci. 2021 Apr 1;22(7). DOI: https://doi.org/10.3390/ijms22073559
Williams KM, et al. Safety of photosynthetic Synechococcus elongatus for in vivo cyanobacteria–mammalian symbiotic therapeutics. 2020;13:1780–92. DOI: https://doi.org/10.1111/1751-7915.13596
Liu Y, Zhong D, He Y, Jiang J, Xie W, Tang Z, et al. Photoresponsive Hydrogel-Coated Upconversion Cyanobacteria Nanocapsules for Myocardial Infarction Prevention and Treatment. Advanced Science. 2022 Oct 25;9(30). DOI: https://doi.org/10.1002/advs.202202920
Younis NS, Bakir EM, Mohamed ME, El Semary NA. Cyanobacteria as nanogold factories II: Chemical Reactivity and anti-Myocardial Infraction Properties of Customized Gold Nanoparticles Biosynthesized by Cyanothece sp. Mar Drugs. 2019;17(7). DOI: https://doi.org/10.3390/md17070402
Bakir EM, Younis NS, Mohamed ME, El Semary NA. Cyanobacteria as nanogold factories: Chemical and anti-myocardial infarction properties of gold nanoparticles synthesized by lyngbya majuscula. Mar Drugs. 2018 Jun 1;16(6). DOI: https://doi.org/10.3390/md16060217
Osbourne NJT, Webb PM, Shaw GR. The toxins of Lyngbya majuscula and their human and ecological health effects. Environmental International. 2011;27:381–92. DOI: https://doi.org/10.1016/S0160-4120(01)00098-8
Vitek L. The role of bilirubin in diabetes, metabolic syndrome, and cardiovascular diseases. Front Pharmacol. 2012;55. DOI: https://doi.org/10.3389/fphar.2012.00055
Rodrigo R, Retamal C, Schupper D, Vergara-Hernández D, Saha S, Profumo E, et al. Antioxidant Cardioprotection against Reperfusion Injury: Potential Therapeutic Roles of Resveratrol and Quercetin. Vol. 27, Molecules. MDPI; 2022. DOI: https://doi.org/10.3390/molecules27082564
Strasky Z, Zemankova L, Nemeckova I, Rathouska J, Wong RJ, Muchova L, et al. Spirulina platensis and phycocyanobilin activate atheroprotective heme oxygenase-1: a possible implication for atherogenesis. Food Funct. 2013;4(11):1586–94. DOI: https://doi.org/10.1039/c3fo60230c
Khan M et al. C-phycocyanin protects against ischemia-reperfusion injury of heart through involvement of p38 MAPK and ERK signaling. Am J Physiol Heart Circ Physiol . 2006;290(5):136–45. DOI: https://doi.org/10.1152/ajpheart.01072.2005
Klebanoff SJ. Myeloperoxidase: friend and foe. J Leukoc Biol . 2005;77(5):598–625. DOI: https://doi.org/10.1189/jlb.1204697
Chen M, Blankenship RE. Expanding the solar spectrum used by photosynthesis. Trends Plant Sci. 2011;16(8):427–31. DOI: https://doi.org/10.1016/j.tplants.2011.03.011
Cohen JE, Goldstone AB, Paulsen MJ, Shudo Y, Steele AN, Edwards BB, et al. An innovative biologic system for photon-powered myocardium in the ischemic heart. Health and Medicine [Internet]. 2017;3:e1603078. Available from: http://advances.sciencemag.org/ DOI: https://doi.org/10.1126/sciadv.1603078
Stapleton LM, Farry JM, Zhu Y, Lucian HJ, Wang H, Paulsen MJ, et al. Microfluidic encapsulation of photosynthetic cyanobacteria in hydrogel microparticles augments oxygen delivery to rescue ischemic myocardium. J Biosci Bioeng. 2023 Jun 1; DOI: https://doi.org/10.1016/j.jbiosc.2023.03.001
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