Plasma antioxidant substances apparently do not influence the radiodermatitis occurrence
DOI:
https://doi.org/10.15448/1980-6108.2020.1.35844Keywords:
Breast cancer, Oxidative stress, Radiotherapy, Thiobarbituric acid reactive substances, RadiodermatitisAbstract
AIMS: Radiation affects not only tumors but also healthy tissues through the increment of oxidative stress. Thus, this study aimed to evaluate the oxidative stress degree as well as non-enzymatic antioxidant defenses in the plasma of patients submitted to radiotherapy and to verify if these parameters are modified in those patients who develop radiodermatitis.
METHODS: Forty-one patients submitted to radiotherapy for treatment of breast cancer were followed. From these patients, plasma samples were obtained at the beginning, in the middle and at the end of the treatment, for analysis of thiobarbituric acid reactive substances (TBARS) and ferric reducing ability of plasma (FRAP).
RESULTS: No significant differences were observed in terms of TBARS and FRAP in plasma harvested from these patients at the beginning and at the middle of the treatment. There was lower incidence of grade two radiodermatitis among patients undergoing radiotherapy with hypofractionated doses. There were no differences in FRAP or TBARS among patients who developed radiodermatitis of any degree in relation to those who did not develop this side effect. No differences of FRAP or TBARS were observed between patients that presented grade two radiodermatitis regarding to the others studied.
CONCLUSION: There was no clear relationship between changes in TBARS or FRAP with the occurrence or severity of radiodermatitis.
Downloads
References
Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global Cancer Statistics, 2012. CA Cancer J Clin. 2015;65(2):87-108. https://doi.org/10.3322/caac.21262
Instituto Nacional de Câncer José Alencar Gomes da Silva, Brasil. Apresentação e Introdução [Presentation and Introduction]. INCA. 1996-2020. [cited 2020 Abr 19]. Available from: https://www.inca.gov.br/estimativa/introducao
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018; 68(6):394-24. https://doi.org/10.3322/caac.21492
Darby S, McGale P, Correa C, Taylor C, Arriagada R, Clarke M, Cutter D, Davies C, Ewertz M, Godwin J, Gray R, Pierce L, Whelan T, Wang Y, Peto R. Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10,801 women in 17 randomised trials. Lancet. 2011; 378(9804):1707-16. https://doi.org/10.1016/S0140-6736(11)61629-2
McGale P, Taylor C, Correa C, Cutter D, Duane F, Ewertz M, Gray R, Mannu G, Peto R, Whelan T, Wang Y, Wang Z, Darby S. Effect of radiotherapy after mastectomy and axillary surgery on 10-year recurrence and 20-year breast cancer mortality: meta-analysis of individual patient data for 8135 women in 22 randomised trials. Lancet. 2014; 383(9935):2127-35. https://doi.org/10.1016/S0140-6736(14)60488-8
Iliakis G, Dahm-Daphi J, Dikomey E. DNA repair and cell cycle regulation after ionizing irradiation. In: Molls M, Vaupel P, Nieder C, Anscher MS, editors. The impact of tumor biology on cancer treatment and multidisciplinary strategies. Berlin: Springer; 2009. p. 251-72. https://doi.org/10.1007/978-3-540-74386-6_14
West CM, Barnett GC. Genetics and genomics of radiotherapy toxicity: towards prediction. Genome Med. 2011; 3(8):52. https://doi.org/10.1186/gm268
O’Driscoll M, Jeggo PA. The role of double-strand break repair - insights from human genetics. Nat Rev Genet. 2006; 7(1):45-54. https://doi.org/10.1038/nrg1746
Zhao W, Diz DI, Robbins ME. Oxidative damage pathways in relation to normal tissue injury. Br J Radiol. 2007; 80(1):23-31. https://doi.org/10.1259/bjr/18237646
Chistiakov DA, Voronova NV, Chistiakov PA. Genetic variations in DNA repair genes, radiosensitivity to cancer and susceptibility to acute tissue reactions in radiotherapy- treated cancer patients. Acta Oncol. 2008; 47(5):809- 24. https://doi.org/10.1080/02841860801885969
Lim KH, Lee CY, Earnest A, Seet RC, Halliwell B. Does radiotherapy increase oxidative stress? A study with nasopharyngeal cancer patients revealing anomalies in isoprostanes measurements. Free Radic Res. 2010; 44(9):1064-71. https://doi.org/10.3109/10715762.2010.499906
Azzam EI, Jay-Gerin JP, Pain D. Ionizing radiation- induced metabolic oxidative stress and prolonged cell injury. Cancer Lett. 2012; 327(1-2):48-60. https://doi.org/10.1016/j.canlet.2011.12.012
Schreiber GJ, Meyers AD. General principles of radiation therapy. [online publication]; 2018 [cited 2020 Jul 19]. Available from https://emedicine.medscape.com/article/846797-overview
Chies AB, Munhoz GC, de Oliveira PB. Desafios relacionados à avaliação do estresse oxidativo no processo de envelhecer. RBCEH. 2019; 16(1):38-43. https://doi.org/10.5335/rbceh.v16i1.9770
Benzie IF, Strain JJ. The ferric reducing ability of plasma (FRAP) as a measure of “antioxidant power”: the FRAP assay. Anal Biochem. 1996; 239(1):70-6. https://doi.org/10.1006/abio.1996.0292
Reddy PE, Manohar SM, Reddy SV, Bitla AR, Vishnubhotla S, Narasimha SRPVL. Ferric reducing ability of plasma and lipid peroxidation in hemodialysis patients: intradialytic changes. Int J Nephrol Urol. 2010; 2(3):414-21.
Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 1979; 95(2):351-58. https://doi.org/10.1016/0003-2697(79)90738-3
Yagi K. Assay for serum lipid peroxide level and its clinical significance. In: Yagi K, editor. Lipid Peroxides in Biology and Medicine. New York (NY): Academic Press; 1982. p. 223-242. https://doi.org/10.1016/B978-0-12-768050-7.50020-2
Wills ED. Mechanism of lipid peroxide formation in animal tissues. Biochem J. 1966; 99(5) 667-76. https://doi.org/10.1042/bj0990667
Zenda S, Ota Y, Tachibana H, Ogawa H, Ishii S, Hashiguchi C, Akimoto T, Ohe Y, Uchitomi Y. A prospective picture collection study for a grading atlas of radiation dermatitis for clinical trials in head-and-neck cancer patients. J Radiat Res. 2016; 57(3):301-06 https://doi.org/10.1093/jrr/rrv092
Araújo IBS, Leite CB, Amorim TO, Silva ANL, Fernandes RSQ, Carmo MS. Câncer de mama em homens. Rev Investig Biomed. 2018; 10(3):272-79. Brazilian. https://doi.org/10.24863/rib.v10i3.347
American Cancer Society, United States of America. Breast Cancer, Understanding a breast cancer diagnosis. Types of breast cancer. 2019. [cited 2020 Apr 26]. Available from: https://www.cancer.org/cancer/breast-cancer/understanding-a-breast-cancer-diagnosis/types-of-breast-cancer.html
Antonio Cândido de Camargo Cancer Center. Tipos de Câncer, Mama. [online publication]; 2018 [cited 2020 Apr 26]. Available from: https://accamargo.org.br/tipos-de-cancer/mama
United States of America. National Institute for Health (NIH). National Cancer Institute. Cancer Types. Breast Cancer. Breast cancer treatment (Adult) (PDQ®) - Health professional version., Histopathologic classification of breast cancer. 2018. [cited 2020 Apr 26]. Available from: https://www.cancer.gov/types/breast/hp/breast-treatment-pdq#link/_18
Filho VW, Mirra AP, López RVM, Antunes LF. Tabagismo e câncer no Brasil: evidências e perspectivas. Rev Bras Epidemiol. 2010; 13(2):175-187. https://doi.org/10.1590/S1415-790X2010000200001
Brasil. Ministério da Saúde. Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA).Tipos de câncer. Câncer de mama. 2020. [cited 2020 Abr 19]. Available from: https://www.inca.gov.br/tipos-de-cancer/cancer-de-mama
Brasil. Ministério da Saúde. Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA). Tabagismo. Causas e prevenção. Tabagismo. 2020. [cited 2020 Abr 19]. Available from: https://www.inca.gov.br/tabagismo
Spence RAJ, Johnston PG. Oncologia. Rio de Janeiro: Guanabara; 2003.
Olusi SO. Obesity is an independent risk factor for plasma lipid peroxidation and depletion of erythrocyte cytoprotectic enzymes in humans. Int J Obes Relat Metab Disord. 2002; 26(9):1159-64. https://doi.org/10.1038/sj.ijo.0802066
Melissas J, Malliaraki N, Papadakis JA, Taflampas P, Kampa M, Castanas E. Plasma antioxidant capacity in morbidly obese patients before and after weight loss. Obes Surg. 2006; 16(3):314-20. https://doi.org/10.1381/096089206776116444
Porock D, Kristjanson L. Skin reactions during radiotherapy for breast cancer: the use and impact of topical agents and dressings. Eur J Cancer Care. 1999; 8(3):143-53. https://doi.org/10.1046/j.1365-2354.1999.00153.x
Chen PY, Wallace M, Mitchell C, Grills I, Kestin L, Fowler A, Martinez A, Vicini F. Four-year efficacy, cosmesis, and toxicity using three-dimensional conformal external beam radiation therapy to deliver accelerated partial breast irradiation. Int J Radiat Oncol Biol Phys. 2010; 76(4):991-97. https://doi.org/10.1016/j.ijrobp.2009.03.012
Ray KJ, Sibson NR, Kiltie AE. Treatment of breast and prostate cancer by hypofractionated radiotherapy: potential risks and benefits. Clin Oncol (R Coll Radiol). 2015; 27(7):420-26. https://doi.org/10.1016/j.clon.2015.02.008
Ritter M. Rationale, conduct, and outcome using hypofractionated radiotherapy in prostate cancer. Semin Radiat Oncol. 2008; 18(4):249-56. https://doi.org/10.1016/j.semradonc.2008.04.007
Parthan A, Pruttivarasin N, Davies D, Taylor DC, Pawar V, Bijlani A, Lich KH, Chen RC. Comparative cost effectiveness of stereotactic body radiation therapy versus intensity-modulated and proton radiation therapy for localized prostate cancer. Front Oncol. 2012; 2:81. https://doi.org/10.3389/fonc.2012.00081
Sethukavalan P, Cheung P, Tang CI, Quon H, Morton G, Nam R, Loblaw A. Patient costs associated with external beam radiotherapy treatment for localized prostate cancer: the benefits of hypofractionated over conventionally fractionated radiotherapy. Can J Urol. 2012; 19(2):6165-9.
Shaitelman SF, Schlembach PJ, Arzu I, Ballo M, Bloom ES, Buchholz D, Chronowski GM, Dvorak T, Grade E, Hoffman KE, Kelly P, Ludwig M, Perkins GH, Reed V, Shah S, Stauder MC, Strom EA, Tereffe W, Woodward WA, Ensor J et al. Acute and Short- -term Toxic Effects of Conventionally Fractionated vs Hypofractionated Whole-Breast Irradiation: A Randomized Clinical Trial. JAMA Oncol. 2015;1(7):931-41. https://doi.org/10.1001/jamaoncol.2015.2666
Mello Filho AC, Hoffmann ME, Meneghini R. Cell killing and DNA damage by hydrogen peroxide are mediated by intracellular iron. Biochem J. 1984; 218(1):273-5. https://doi.org/10.1042/bj2180273
Hershko C. Mechanism of iron toxicity and its possible role in red cell membrane damage. Semin Hematol. 1989; 26(4):277-85.
Shan XQ, Aw TY, Jones DP. Glutathione-dependent protection against oxidative injury. Pharmacol Ther. 1990; 47(1):61-71. https://doi.org/10.1016/0163-7258(90)90045-4
Shan XQ, Aw TY, Jones DP. Glutathione-dependent protection against oxidative injury. Pharmacol Ther. 1990; 47(1):61-71. https://doi.org/10.1016/0163-7258(90)90045-4
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2020 Scientia Medica
This work is licensed under a Creative Commons Attribution 4.0 International License.
