Relationships between physical activity, smoking, nasal mucociliary transportability and pulmonary function
DOI:
https://doi.org/10.15448/1980-6108.2017.3.26920Keywords:
smoking, exercise, mucociliary clearance, mucociliary transport, lung.Abstract
***Relationships between physical activity, smoking, nasal mucociliary transportability and pulmonary function***
AIMS: To compare smokers and non-smokers, physically active and insufficiently active, on mucociliary transportability and lung function.
METHODS: Cross-sectional study. The volunteers were interviewed to obtain personal data, information on smoking habits and level of physical activity. Then, they were evaluated for anthropometric data, nasal mucociliary transport (by saccharin transit time test) and lung function (by measuring forced expiratory volume in the first second and forced vital capacity). Analysis of variance was used for investigation between the groups and analysis of covariance (adjusted for confounding factors) to investigate cofactors on the transit time of saccharin. The significance level of 5% and the 95% confidence interval were adopted.
RESULTS: A total of 139 individuals were selected and assigned to four groups, according to the smoking habits and the level of physical activity: 45 smokers who were not physically active; 25 physically active smokers; 31 non-smokers who were not physically active; and 38 physically active non-smokers. The mean age and body mass index did not present statistically significant differences between the four groups. In the saccharin transit time test, physically active non-smokers presented a time of 8.73 minutes, while in the insufficiently active, the time was 13.0 minutes (p=0.0409). Physically active smokers presented lower values of forced expiratory volume in the first second compared to those who were not physically active (z score in relation to predicted values -1.01 and -0.55, respectively; p=0.0207).
CONCLUSIONS: In this sample of healthy adults of both sexes, the practice of physical activity was beneficial for nasal mucociliary transportability, but only in individuals who never smoked. On the other hand, physically active smokers presented lower values of lung function when compared to insufficiently active smokers, suggesting that physical exercises may cause additional lung function impairment if the individual does not change the smoking habit.
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References
Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health. The Health Consequences of Smoking – 50 Years of Progress: A Report of the Surgeon General, 2014 [Internet]. Atlanta; 2014 [cited 2017 February]. Available from: https://www.surgeongeneral.gov/library/reports/50-years-of-progress/
Centro de Vigilância Sanitária, Coordenadoria de Controle de Doenças, Secretaria de Estado da Saúde. Vigilância sanitária do tabaco no estado de São Paulo. Rev Saúde Pública. 2012;46(2):395-7.
World Health Organization. WHO report on the global tobacco epidemic, 2011 [Internet]. Geneva; 2011 [cited 2017 February]. Available from: http://www.who.int/tobacco/global_report/2011/en/
Action on Smoking and Health – ASH. Smoking and respiratory disease [Internet]. [updated 2015; cited 2017 February]. Available from: http://ash.org.uk/information-and-resources/fact-sheets/smoking-and-respiratory-disease/
Xavier RF, Ramos D, Ito JT, Rodrigues FM, Bertolini GN, Macchione M, de Toledo AC, Ramos EM. Effects of cigarette smoking intensity on the mucociliary clearance of active smokers. Respiration. 2013;86(6):479-85. https://doi.org/10.1159/000348398
Anthonisen NR, Connett JE, Murray RP. Smoking and lung function of Lung Health Study participants after 11 years. Am J Respir Crit Care Med. 2002;166(5):675-9. https://doi.org/10.1164/rccm.2112096
Wang Y, Li M, Dong F, Zhang J, Zhang F. Physical exercise-induced protection on ischemic cardiovascular and cerebrovascular diseases. Int J Clin Exp Med. 2015;8(11):19859-66.
Warburton DER, Nicol CW, Bredin SSD. Health benefits of physical activity: the evidence. CMAJ : Canadian Medical Association Journal. 2006;174(6):801-9. https://doi.org/10.1503/cmaj.051351
Garcia-Aymerich J, Lange P, Benet M, Schnohr P, Anto JM. Regular physical activity modifies smoking-related lung function decline and reduces risk of chronic obstructive pulmonary disease: a population-based cohort study. Am J Respir Crit Care Med. 2007;175(5):458-63. https://doi.org/10.1164/rccm.200607-896OC
Salzano FA, Manola M, Tricarico D, Precone D, Motta G. Mucociliary clearance after aerobic exertion in athletes. Acta Otorhinolaryngol Ital. 2000;20(3):171-6.
Wolff RK, Dolovich MB, Obminski G, Newhouse MT. Effects of exercise and eucapnic hyperventilation on bronchial clearance in man. J Appl Physiol Respir Environ Exerc Physiol. 1977;43(1):46-50.
Leite MR, Ramos EM, Kalva-Filho CA, Freire AP, de Alencar Silva BS, Nicolino J, de Toledo-Arruda AC, Papoti M, Vanderlei LC, Ramos D. Effects of 12 weeks of aerobic training on autonomic modulation, mucociliary clearance, and aerobic parameters in patients with COPD. Int J Chron Obstruct Pulmon Dis. 2015;10:2549-57. https://doi.org/10.2147/COPD.S81363
Freire APCFF, Ramos D, Silva BSA, David RM, Pestana PRS, Fernandes RA, Ramos EMC. Resultados de um programa de cessação tabagística: análise de novos procedimentos. ConScientiae Saúde. 2014;13(3):396-404. https://doi.org/10.5585/conssaude.v13n3.4894
Nicola ML, Carvalho HB, Yoshida CT, Anjos FM, Nakao M, Santos Ude P, Cardozo KH, Carvalho VM, Pinto E, Farsky SH, Saldiva PH, Rubin BK, Nakagawa NK. Young "healthy" smokers have functional and inflammatory changes in the nasal and the lower airways. Chest. 2014;145(5):998-1005. https://doi.org/10.1378/chest.13-1355
Knowles MR, Boucher RC. Mucus clearance as a primary innate defense mechanism for mammalian airways. J Clin Invest. 2002;109(5):571-7. https://doi.org/10.1172/JCI0215217
Pereira CAC. Espirometria. J Bras Pneumol. 2002;28(3):1-82.
Reichert J, de Araújo AJ, Gonçalves CMC, Godoy I, Chatkin JM, Sales MPU, Santos SRRA. Diretrizes para cessação do tabagismo – 2008. J Pneumol. 2008;34(20):845-80. https://doi.org/10.1590/S1806-37132008001000014
Instituto Brasileiro de Geografia e Estatística (IBGE). Ministério do Planejamento Orçamento e Gestão. Manual de antropometria. In: Pesquisa Nacional de Saúde 2013. Rio de Janeiro; 2013.
Heatherton TF, Kozlowski LT, Frecker RC, Fagerström KO. The Fagerström Test for Nicotine Dependence: a revision of the Fagerström Tolerance Questionnaire. Br J Addict. 1991;86(9):1119-27. https://doi.org/10.1111/j.1360-0443.1991.tb01879.x
Meneses-Gaya IC, Zuardi AW, Loureiro SR, JAS. C. As propriedades psicométricas do Teste de Fagerström para Dependência de Nicotina. J Bras Pneumol. 2009;35(1):73-82. https://doi.org/10.1590/S1806-37132009000100011
Pardini R, Matsudo S, Araujo T, Matsudo V, Andrade E, Bragglon G, Andrade D, Oliveira L, Junior AF, Raso V. Validação do questionário internacional de nível de atividade física (IPAQ - versão 6): estudo piloto em adultos jovens brasileiros. Rev Bras Ciên e Mov. 2001;9(3):45-51.
Santos UP, Gannam S, Abe JM, Esteves PB, Filho MF, Wakassa TB, Issa JS, Terra-Filho M, Stelmach R, Cukier A. Emprego da determinação de monóxido de carbono no ar exalado para a detecção do consumo de tabaco. J Bras Pneumol. 2001;27(5):231-6. https://doi.org/10.1590/S0102-35862001000500001
Salah B, Dinh Xuan AT, Fouilladieu JL, Lockhart A, Regnard J. Nasal mucociliary transport in healthy subjects is slower when breathing dry air. Eur Respir J. 1988;1(9):852-5.
Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, Crapo R, Enright P, Van Der Grinten CP, Gustafsson P, Jensen R, Johnson DC, MacIntyre N, McKay R, Navajas D, Pedersen OF, Pellegrino R, Viegi G, Wanger J, Ats Ers Task Force. Standardisation of spirometry. Eur Respir J. 2005;26(2):319-38. https://doi.org/10.1183/09031936.05.00034805
Quanjer PH, Stanojevic S, Cole TJ, Baur X, Hall GL, Culver BH, Enright PL, Hankinson JL, Ip MSM, Zheng J, Stocks J, the ERS Global Lung function Initiative. Multi-ethnic reference values for spirometry for the 3–95 year age range: The global lung function 2012 equations: Report of the Global Lung Function Initiative (GLI), ERS Task Force to establish improved Lung Function Reference Values. Eur Respir J. 2012;40(6):1324-43. https://doi.org/10.1183/09031936.00080312
Nicod LP. Pulmonary defence mechanisms. Respiration. 1999;66(1):2-11. https://doi.org/10.1159/000029329
Chilvers MA, O'Callaghan C. Local mucociliary defence mechanisms. Paediatr Respir Rev. 2000;1(1):27-34. https://doi.org/10.1053/prrv.2000.0009
Knowles MR, Boucher RC. Mucus clearance as a primary innate defense mechanism for mammalian airways. J Clin Invest. 2002;109(5):571-7. https://doi.org/10.1172/JCI0215217
Valia PP, Valero FC, Pardo JM, Rentero DB, Monte CG. Saccharin test for the study of mucociliary clearance: reference values for a Spanish population. Arch Bronconeumol. 2008;44(10):540-5. https://doi.org/10.1016/S1579-2129(08)60100-7
Baby MK, Muthu PK, Johnson P, Kannan S. Effect of cigarette smoking on nasal mucociliary clearance: A comparative analysis using saccharin test. Lung India. 2014;31(1):39-42. https://doi.org/10.4103/0970-2113.125894
Cannon JG, Meydani SN, Fielding RA, Fiatarone MA, Meydani M, Farhangmehr M, Orencole SF, Blumberg JB, Evans WJ. Acute phase response in exercise. II. Associations between vitamin E, cytokines, and muscle proteolysis. Am J Physiol. 1991;260(6 Pt 2):R1235-40.
Rosa C, Vaisberg LFPB, Mauro W. Influências do exercício na resposta imune. Rev Bras Med Esp. 2002;8:167-72. https://doi.org/10.1590/S1517-86922002000400006
Holmqvist N, Secher NH, Sander-Jensen K, Knigge U, Warberg J, Schwartz TW. Sympathoadrenal and parasympathetic responses to exercise. J Sports Sci. 1986;4(2):123-8. https://doi.org/10.1080/02640418608732108
Mackinnon LT, Chick TW, van As A, Tomasi TB. The effect of exercise on secretory and natural immunity. Adv Exp Med Biol. 1987;216:869-76.
Ramos EM, Vanderlei LC, Ito JT, Lima FF, Rodrigues FM, Manzano BM, Fernandes RA, Cecilio MJ, Toledo-Arruda AC, Ramos D. Acute Mucociliary Clearance Response to Aerobic Exercise in Smokers. Respir Care. 2015;60(11):1575-84. https://doi.org/10.4187/respcare.04093
Proença M, Pitta F, Kovelis D, Mantoani LC, Furlanetto KC, Zabatiero J, Ramosa D, Ramos EMC. Transporte mucociliar e sua relação com o nível de atividade física na vida diária em fumadores saudáveis e não fumadores. Rev Port Pneumol. 2012;18(5):233-8. https://doi.org/10.1016/j.rppneu.2012.03.003
Rosa CSC, Rossi FE, Buonani C, Fernandes RA, Monteiro HL, Junior IFF. The agreement between physical activity time reported by the IPAQ and accelerometer in postmenopausal women. Motricidade. 2015;11:6-13. https://doi.org/10.6063/motricidade.4100
Millar AB, Agnew JE, Newman SP, Lopez-Vidriero MT, Pavia D, Clarke SW. Comparison of nasal and tracheobronchial clearance by similar techniques in normal subjects. Thorax. 1986;41(10):783-6. https://doi.org/10.1136/thx.41.10.783
Trindade SHK, Mello Júnior JFd, Mion OdG, Lorenzi-Filho G, Macchione M, Guimarães ET, Saldiva PHN. Métodos de estudo do transporte mucociliar. Rev Bras Otorrinolaringol. 2007;73:704-12. https://doi.org/10.1590/S0034-72992007000500018
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