Spontaneous abortion and ocular toxoplasmosis in a couple infected with Toxoplasma gondii
DOI:
https://doi.org/10.15448/1980-6108.2015.3.21119Keywords:
Toxoplasma gondii, toxoplasmosis, congenital, ocular, transmission, vertical, chorioretinitis.Abstract
Aims: To report the cases of wife and husband with toxoplasmosis. The woman acquired the infection during pregnancy while her husband was diagnosed with ocular toxoplasmosis 15 years later.
Cases report: A woman with twin pregnancy, living in southern Brazil, was seronegative for Toxoplasma gondii IgG and IgM antibodies in the first month of gestation. Seroconversion (positive T. gondii IgM and IgG antibodies) occurred in the seventh week of gestation, resulting in spontaneous abortion. Fifteen years later, her husband presented with eye irritation and blurred vision. The funduscopic examination revealed typical lesions of recurrent chorioretinitis in the right eye. The serological tests were positive for T. gondii IgG and negative for IgM.
Conclusions: This report of a couple with important clinical outcomes of two different types of toxoplasmosis underscores the importance of this disease which, in its various manifestations, may have serious consequences for a family's life.
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References
Dubey J. Toxoplasmosis of animals and humans. 2a ed. New York: CRC Press; 2010.
Tenter AM, Heckeroth AR, Weiss LM. Toxoplasma gondii: from animals to humans. Int J Parasitol. 2000 Nov;30(12-13):1217-58. http://dx.doi.org/10.1016/S0020-7519(00)00124-7
Jones JL, Dubey JP. Waterborne toxoplasmosis-recent developments. Exp Parasitol. 2010 Jan;124(1):10-25. http://dx.doi.org/10.1016/j.exppara.2009.03.013
Montoya JG, Remington JS. Management of toxoplasma gondii infection during pregnancy. Clin Infect Dis. 2008 Aug 15;47(4):554-66. http://dx.doi.org/10.1086/590149
Remington JS, Klein JO, Wilson CB, editors. Infectious diseases of the fetus and newborn infant. 7th ed. Philadelphia: Elsevier Saunders; 2011.
Carneiro AC, Andrade GM, Costa JG, Pinheiro BV, Vasconcelos-Santos DV, Ferreira AM, Su C, Januário JN, Vitor RW. Genetic characterization of toxoplasma gondii revealed highly diverse genotypes for isolates from newborns with congenital toxoplasmosis in Southeastern Brazil. J Clin Microbiol. 2013 Mar;51(3):901-7. http://dx.doi.org/10.1128/JCM.02502-12
Grigg ME, Dubey JP, Nussenblatt RB. Ocular toxoplasmosis: lessons from Brazil. Am J Ophthalmol. 2015 Jun;159(6):999-1001. http://dx.doi.org/10.1016/j.ajo.2015.04.005
Silveira C, Muccioli C, Holland GN, Jones JL, Yu F, Paulo A, Belfort Jr R. Ocular involvement following an epidemics of Toxoplasma gondii infection in Santa Isabel do Ivaí, Brazil. Am J Ophthalmol. 2015 Jun;159(6):1013-1021.e3. http://dx.doi.org/10.1016/j.ajo.2015.02.017
Melamed J. Contributions to the history of ocular toxoplasmosis in Southern Brazil. Mem Inst Oswaldo Cruz. 2009 Mar;104(2):358-63. http://dx.doi.org/10.1590/S0074-02762009000200032
Kravetz J. Congenital toxoplasmosis. BMJ Clin Evid. 2010 Jun 28;2010.
Boyer KM, Holfels E, Roizen N, Swisher C, Mack D, Remington J, Withers S, Meier P, McLeod R; Toxoplasmosis Study Group. Risk factors for Toxoplasma gondii infection in mothers of infants with congenital toxoplasmosis: Implications for prenatal management and screening. Am J Obstet Gynecol. 2005 Feb;192(2):564-71. http://dx.doi.org/10.1016/j.ajog.2004.07.031
Robert-Gangneux F, Dardé ML. Epidemiology of and diagnostic strategies for toxoplasmosis. Clin Microbiol Rev. 2012 Apr;25(2):264-96 http://dx.doi.org/10.1128/CMR.05013-11
Vaudaux JD, Muccioli C, James ER, Silveira C, Magargal SL, Jung C, Dubey JP, Jones JL, Doymaz MZ, Bruckner DA, Belfort R Jr, Holland GN, Grigg ME. Identification of an atypical strain of Toxoplasma gondii as the cause of a waterborne outbreak of toxoplasmosis in Santa Isabel do Ivai, Brazil. J Infect Dis. 2010 Oct 15;202(8):1226-33. http://dx.doi.org/10.1086/656397
Mattos CC, Meira CS, Ferreira AI, Frederico FB, Hiramoto RM, Jr GC, Mattos LC, Pereira-Chioccola VL. Contribution of laboratory methods in diagnosing clinically suspected ocular toxoplasmosis in Brazilian patients. Diagn Microbiol Infect Dis. 2011 Jul;70(3):362-6. http://dx.doi.org/10.1016/j.diagmicrobio.2011.02.002
Silveira C, Vallochi AL, Rodrigues da Silva U, Muccioli C, Holland GN, Nussenblatt RB, Belfort R, Rizzo LV. Toxoplasma gondii in the peripheral blood of patients with acute and chronic toxoplasmosis. Br J Ophthalmol. 2011 Mar;95(3):396-400. http://dx.doi.org/10.1136/bjo.2008.148205
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