Applicability and safety of sodium nitroprusside to control arterial pressure during thrombolysis in the treatment of acute ischemic stroke <b>[Abstract in English]</b>

e-ISSN: 1980-6108
ISSN-L: 1806-5562

Fábio Pascotto de Oliveira; Charles Luiz Klant; Mauricio André Gheller Friedrich

Authors

Fábio Pascotto de Oliveira Hospital São Lucas
Charles Luiz Klant Hospital São Lucas
Mauricio André Gheller Friedrich Hospital São Lucas Pucrs

Keywords:

acidente vascular cerebral, alteplase, nitroprussiato, isquêmico, pressão arterial

Abstract

Aims: To report the experience with sodium nitroprusside in the treatment of acute ischemic cerebral stroke. Methods: A retrospective study, conducted by review of hospital charts, included patients who suffered an acute ischemic cerebral stroke and received thrombolytic therapy with alteplase, from May 2005 to July 2007. Results: Of 48 patients who meet the inclusion criteria, 15 received sodium nitroprusside to control the arterial pressure. One patient (6,7%) died, and none had symptomatic intracerebral hemorrhage. The median score for National Institute of Health Stroke Scale at the arrival was 10, and at discharge was 2,8. Conclusions: Sodium nitroprusside in the acute ischemic cerebral stroke was applicable and safe. Larger and prospective studies are necessary to corroborate these results and evaluate its potential protective properties. KEY WORDS: NITROPRUSSIDE; STROKE; ACUTEPHASE REACTION; TISSUE PLASMINOGEN ACTIVATOR; BLOOD PRESSURE; BRAIN ISCHEMIA.