Cyanobacteria for Cardiomyocyte Protection against miocardial ischemia injury: a systematic review of animal and in vitro studies

Guilherme Scotta Hentschke; Vítor Scotta Hentschke; Fabiano Moraes Miguel

doi:10.15448/1980-6108.2024.1.44970

Autores

Guilherme Scotta Hentschke CIIMAR https://orcid.org/0000-0003-4396-024X
Vítor Scotta Hentschke Lutheran University of Brazil (Ulbra), Cachoeira do Sul, RS, Brazil. https://orcid.org/0000-0001-5031-1075
Fabiano Moraes Miguel Lutheran University of Brazil (Ulbra), Cachoeira do Sul, RS, Brazil. https://orcid.org/0000-0002-8037-1658

DOI:

https://doi.org/10.15448/1980-6108.2024.1.44970

Palavras-chave:

cianobatérias, spirulina, isquemia, doenças cardiovasculares.

Resumo

Objetivo: realizar uma revisão sistemática sobre o uso de cianobactérias para proteção do tecido cardíaco contra danos causados pela isquemia.
Métodos: esta revisão abrange estudos experimentais in vitro e estudos controlados em animais.
Resultados: os resultados indicam que, em geral, existem dois tipos de intervenções para o tratamento de isquemia e isquemia/reperfusão (IR) no tecido cardíaco: (1) tratamentos com extratos e (2) injeção de cianobactérias nos tecidos danificados. Os tratamentos com extratos baseiam-se no potencial antioxidante das cianobactérias, e os estudos concentram-se principalmente em Spirulina (Arthrospira platensis). Os métodos de injeção direta são fundamentados na alta capacidade desses organismos de liberar oxigênio durante a fotossíntese. Synechococcus elongatus é a espécie de cianobactéria mais comumente utilizada em injeções, seja entregue de forma independente ou transportada por hidrogéis ou nanopartículas. As injeções diretas de cianobactérias são técnicas inovadoras que podem promover proteção contra a apoptose e mostraram resultados promissores, no entanto, mais pesquisas são necessárias para aprimorar as técnicas e melhorar a eficácia geral.
Conclusão: Os efeitos desses tratamentos foram benéficos, considerando que os efeitos antioxidantes das Cianobactérias melhoram os marcadores bioquímicos sanguíneos e reduzem as áreas cardíacas danificadas. A liberação de oxigênio pelas cianobactérias no tecido cardíaco também promoveu a recuperação do tecido após isquemia ou IR.

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Biografia do Autor

Guilherme Scotta Hentschke, CIIMAR

Doutor em Biodiversidade Vegetal pelo Instituto de Botânica de São Paulo (IBt), SP, Brasil. Investigadora de Pós-Doutoramento no Centro Interdisciplinar de Investigação Marinha e Ambiental (CIIMAR), Portugal. Atualmente trabalha como investigador no CIIMAR.

Vítor Scotta Hentschke, Lutheran University of Brazil (Ulbra), Cachoeira do Sul, RS, Brazil.

PhD in Health Sciences in the Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), in Porto Alegre, RS, Brazil. Currently Professor at Universidade Luterana do Brasil (Ulbra), in Cachoeira do Sul, RS, Brasil.

Fabiano Moraes Miguel, Lutheran University of Brazil (Ulbra), Cachoeira do Sul, RS, Brazil.

PhD in Molecular and Cellular Biology applied on Health Sciences in the Universidade Luterana do Brasil (Ulbra), in Cachoeira do Sul, RS, Brasil. Currently Professor at
Universidade Luterana do Brasil (Ulbra), in Cachoeira do Sul, RS, Brasil.

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