Aspectos oxidativos da síndrome metabólica e aterosclerose
DOI:
https://doi.org/10.15448/1980-6108.2015.3.21092Palavras-chave:
síndrome x metabólica, estresse oxidativo, aterosclerose.Resumo
Objetivos: Realizar uma revisão da literatura sobre os aspectos que envolvem o estresse oxidativo e seu papel na síndrome metabólica e na aterosclerose.
Métodos: A pesquisa foi realizada em abril e maio de 2015, utilizando as bases de dados PubMed, SciELO e LILACS e compreendendo as publicações a partir de 2011. Para a busca dos artigos foram utilizados os seguintes descritores: ((oxidative stress) AND (atherosclerosis OR metabolic syndrome)). Foram selecionados preferencialmente metanálises e ensaios clínicos contendo grande tamanho amostral.
Resultados: Estavam disponíveis 3934 artigos nas bases de dados ao buscar o período e os descritores informados (PubMed 3292, Scielo 588, Lilacs 54). Após eliminadas as referências duplas e aplicados os critérios de inclusão, foram selecionados 53 artigos para esta revisão.
Conclusões: As alterações bioquímicas e antropométricas características da síndrome metabólica relacionam-se a processos inflamatórios e ao estresse oxidativo, que por sua vez estão diretamente relacionados à aterosclerose. Uma melhor compreensão de como as condições que definem a síndrome metabólica favorecem o estresse oxidativo pode contribuir de forma significativa para futuras abordagens ao paciente com doença cardiovascular.
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