Common variable immunodeficiency associated with Crohn-like disease: case report and literature review

  • Larissa Cristina Tavares de Castro Faculdade de Medicina de Marília
  • Zamir Calamita Faculdade de Medicina de Marília
Keywords: common variable immunodeficiency, Crohn disease, immunity, immune system diseases, inflammatory bowel disease.


AIMS: To report the case of a patient diagnosed with common variable immunodeficiency and Crohn-like disease, describing the clinical picture, the diagnostic investigation process, the therapeutic approaches and the clinical outcome of the patient. To carry out a literature review of case reports addressing patients with the common variable immunodeficiency and Crohn-like disease association. Emphasize the importance of early diagnosis and treatment.

CASE DESCRIPTION: A male patient was diagnosed with common variable immunodeficiency at nine years of age and with non-specific inflammatory bowel disease at 10 years, after colonoscopy and colonic biopsy indicated moderate lymphoplasmacytic, eosinophilic infiltrate and some neutrophils in lamina propria, with absence of granulomas. At age 14, the diagnosis of Crohn-like disease was confirmed by specialist after correlation between clinical history and complementary exams. Currently with 18 years of age, the patient is under treatment with intravenous human immunoglobulin, infliximab and azathioprine, with stabilization of the clinical picture.

CONCLUSIONS: The literature review identified 11 case reports on the association between common variable immunodeficiency and Crohn-like disease, with no Brazilian studies, which highlights the rarity of such association. In this report, the patient received extensive and empirical treatments due to the difficulty in reaching a specific diagnosis, which was only performed at age 14, when more targeted and individualized treatment was started. Although currently stable, the patient presented several complications during the diagnostic investigation, which emphasizes the importance of early diagnosis and more precise treatment, targeted to meet the health needs of these patients.


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Author Biographies

Larissa Cristina Tavares de Castro, Faculdade de Medicina de Marília
Graduanda de Medicina na Faculdade de Medicina de Marília
Zamir Calamita, Faculdade de Medicina de Marília
Doutor Chefe da Disciplina de Alergia e Imunopatologia Clínica da Faculdade de Medicina de Marília


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How to Cite
de Castro, L. C. T., & Calamita, Z. (2019). Common variable immunodeficiency associated with Crohn-like disease: case report and literature review. Scientia Medica, 29(1), e32159.
Case Reports