Efeitos do exercício físico regular sobre o fluxo sanguíneo da pele e nos fatores de risco cardiovascular em indivíduos com sobrepeso e obesidade

Autores

DOI:

https://doi.org/10.15448/1980-6108.2022.1.41980

Palavras-chave:

fluxometria laser doppler, óxido nítrico, omentina, obesidade, exercício físico

Resumo

Objetivo: sabe-se que níveis baixos de omentina e a reduzida biodisponibilidade de óxido nítrico (NO) são consequências da obesidade. Além disso, a disfunção microvascular pode ser um estágio inicial de doenças cardiovasculares em indivíduos obesos. Essa situação pode ser avaliada com a fluxometria de pele laser-Doppler (LDF).
Métodos: foram investigados os efeitos do exercício físico moderado por 12 semanas na reatividade microvascular e nos níveis plasmáticos de omentina e NO em 25 indivíduos com sobrepeso e obesidade. O grupo controle foi composto por 28 participantes sedentários que não eram obesos nem com sobrepeso. A reatividade microvascular foi obtida pela medida do fluxo sanguíneo da pele do dedo anelar da mão direita com LDF, que é um método não invasivo de avaliação. Com este método, objetivou-se examinar a resposta da hiperemia reativa pós-oclusiva dos pacientes. Os participantes de ambos os grupos nunca seguiram um cronograma regular de exercícios em sua vida.
Resultados: com o exercício regular houve diminuição estatisticamente significativa dos níveis de glicose (p=0,008), de colesterol (p=0,05) e de triglicerídeos (p=0,048), enquanto o índice de massa corporal e os níveis de lipoproteínas de alta e baixa densidade não se alteraram significativamente no grupo com sobrepeso/ obesidade. Além disso, o nível de omentina aumentou significativamente (p=0,01), mas o nível de NO não apresentou modificações significas. Observou- se, também, que as modificações nos níveis de omentina e NO mensurados antes e após o exercício físico foram significativamente correlacionados (r=0,57). Em relação à microcirculação, os valores do fluxo de repouso (p=0,001) e do valor de fluxo de pico e da LDF (p=0,001) aumentaram após o exercício físico.
Conclusão: nosso estudo mostra que o exercício físico moderado afeta a reatividade microvascular e os níveis plasmáticos de omentina em indivíduos com sobrepeso e obesidade.

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Biografia do Autor

Tuğba Kılıç, Gaziantep University (GAUN), Faculty of Medicine, Physiology Department, Gaziantep, Turkey.

PhD in Physiology Department of Faculty of Medicine of Gaziantep University (GAUN), Gaziantep, Turkey. Practitioner/Clinician in Tuğba Beauty Centre in Gaziantep, Turkey. Graduated from Atatürk University (ATAUNI), Faculty of Medicine, Erzurum, Turkey.

Cahit Bağcı, Sakarya University (SAU), Faculty of Medicine, Physiology Department, Sakarya, Turkey.

PhD in Physiology Department of Graduate School of Health Science of Ankara University, Turkey. Graduated from Ankara University (AU), Faculty of Veterinary Science, Ankara, Turkey. Professor at Physiology Department of Faculty of Medicine of Gaziantep University (GAUN), Turkey. Professor at Physiology Department of Faculty of Medicine of Sakarya University (SU), Turkey.

Mehmet Göl, Gaziantep Islam Science and Technology University (GIBTU), Faculty of Medicine, Department of Medical Physiology, Gaziantep, Turkey.

PhD in Physiology Department of Faculty of Medicine of Gaziantep University (GAUN), Ankara, Turkey. Graduated from Hacettepe University (HU), Faculty of Medicine, Ankara, Turkey. Assistant Professor at Physiology Department of Faculty of Medicine of Gaziantep Islam Science and Technology University (GIBTU), Gaziantep, Turkey.

Hakim Çelik, Harran University (HRU), Faculty of Medicine, Physiology Department, Şanlıurfa, Turkey.

PhD in Physiology Department of Faculty of Medicine of Gaziantep University (GAUN), Gaziantep, Turkey. Master degree in Biochemistry Department of Graduate School of Health Science of Harran University, Şanlıurfa Turkey. Graduated from Harran University (HRU), Biology Department of Faculty of Arts and Science, Şanlıurfa, Turkey. Associate Professor at Physiology Department of Faculty of Medicine of Harran University, Turkey.

Davut Sinan Kaplan, Gaziantep University (GAUN), Faculty of Medicine, Physiology Department, Gaziantep, Turkey.

PhD in Physiology Department of Faculty of Medicine of Gaziantep University (GAUN), Turkey. Graduated from Fırat University (FU), Faculty of Veterinary Science, Elazığ, Turkey. Associate Professor at Physiology Department of Faculty of Medicine of Gaziantep University, Gaziantep Turkey.

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Publicado

2022-05-16

Como Citar

Kılıç, T., Bağcı, C., Göl, M., Çelik, H., & Kaplan, D. S. (2022). Efeitos do exercício físico regular sobre o fluxo sanguíneo da pele e nos fatores de risco cardiovascular em indivíduos com sobrepeso e obesidade. Scientia Medica, 32(1), e41980. https://doi.org/10.15448/1980-6108.2022.1.41980

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