Importance of animal model to test hypotheses about the pathophysiology of the binomial diabetes and female urinary incontinence <br><b>Abstract in English</b>

Authors

  • Gabriela Marini Faculdade de Medicina de Botucatu
  • Fernanda Piculo Faculdade de Medicina de Botucatu
  • Angélica Mércia Pascon Barbosa Faculdade de Medicina de Botucatu
  • Débora Cristina Damasceno Faculdade de Medicina de Botucatu
  • Selma Maria Michelin Matheus Instituto de Biociencias de Botucatu
  • Marilza Vieira Cunha Rudge Faculdade de Medicina de Botucatu

Keywords:

DIABETES MELLITUS/physiopathology, URINARY INCONTINENCE/physiopathology, URETHRA/anatomy & histology, MUSCLE, STRIATED/anatomy & histology, MODELS, ANIMAL, FEMALE, RATS.

Abstract

AIMS: To discuss the importance of studying animal models to test hypotheses about the mechanisms of urinary continence and pathophysiology of diabetes and urinary incontinence. SOURCE OF DATA: A literature review was conducted in PubMed and SciELO. The key words used were diabetes, urinary incontinence, urethra, human and rats. SUMMARY OF FINDINGS: There is a strong relation between the genesis of urinary incontinence and diabetes mellitus. Due to the similarity of normal distribution of skeletal muscle and urethra anatomy between humans and rats, these animal models have been used in current research about these disorders. CONCLUSIONS: The use of rats as an animal model is suitable for experimental studies that test hypotheses about the mechanisms of continence and pathophysiology of the binomial diabetes mellitus and urinary incontinence, thus enabling solutions of great value in clinical practice.

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Author Biographies

Gabriela Marini, Faculdade de Medicina de Botucatu

Doutoranda do Departamento de Ginecologia e Obstetrícia, Faculdade de Medicina de Botucatu, UNESP

Fernanda Piculo, Faculdade de Medicina de Botucatu

Mestranda do Departamento de Ginecologia e Obstetrícia, Faculdade de Medicina de Botucatu, UNESP

Angélica Mércia Pascon Barbosa, Faculdade de Medicina de Botucatu

Departamento de Ginecologia e Obstetrícia, Faculdade de Medicina de Botucatu, UNESP

Débora Cristina Damasceno, Faculdade de Medicina de Botucatu

Pesquisadora do Departamento de Ginecologia e Obstetrícia, Faculdade de Medicina de Botucatu, UNESP

Selma Maria Michelin Matheus, Instituto de Biociencias de Botucatu

Departamento de Anatomia, Instituto de BiociÊncias de BOtucatu, UNESP

Marilza Vieira Cunha Rudge, Faculdade de Medicina de Botucatu

Departamento de Ginecologia e Obstetrícia, Faculdade de Medicina de Botucatu, UNESP

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Published

2011-12-05

How to Cite

Marini, G., Piculo, F., Pascon Barbosa, A. M., Damasceno, D. C., Michelin Matheus, S. M., & Vieira Cunha Rudge, M. (2011). Importance of animal model to test hypotheses about the pathophysiology of the binomial diabetes and female urinary incontinence <br><b>Abstract in English</b>. Scientia Medica, 21(4), 191–195. Retrieved from https://revistaseletronicas.pucrs.br/index.php/scientiamedica/article/view/9230

Issue

Vol. 21 No. 4 (2011)

Section

Review Articles

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