Prognostic factors and long-term survival in oral squamous cell carcinoma

A cross-sectional study

Authors

DOI:

https://doi.org/10.15448/1980-6108.2021.1.41124

Keywords:

prognosis, survival analysis, medical records, mouth neoplasms, carcinoma squamous cell

Abstract

Objective: this study aimed to evaluate long-term survival and prognostic factors in patients with oral squamous cell carcinoma (OSCC) in an economically poor region of Brazil.
Methods: the data were obtained from analysis of medical and mortality records of 210 patients with OSCC treated at an oncology hospital providing services to the Brazilian Unified National Health System in a State of northeastern Brazil between January 2006 and December 2008. Sociodemographic and clinical information, treatment performed, recurrence and evolution were collected. Survival curves were estimated by the Kaplan-Meier method and the log rank and Cox regression tests were used to compare the curves.
Results: the median survival in the study period was 47.4 months (95% CI = 38.2 - 56.7). The overall survival rates at 5 and 10 years were 29% and 19.8%, respectivelly. Individuals over 60 years of age (HR = 1.70; 95% CI = 1.06 - 2.73), presence of regional metastasis (HR = 2.51; 95% CI = 1.55 - 4.08), presence of recurrence (HR = 3.18; 95% CI = 1.88 - 5.39) and no surgical treatment (HR = 2.10; 95% CI = 1.31 - 3.35) had a worse prognosis.
Conclusions: advanced age, presence of regional metastasis, tumor recurrence and non-surgical treatment predict poorer survival in patients diagnosed with OSCC.

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Author Biographies

Carlos Eduardo Moura Carvalho Rocha, Universidade Estadual do Piauí (UESPI), Teresina, PI, Brazil.

Medical student at State University of Piauí (UESPI), Teresina, PI, Brazil.

Júlio César Saraiva Santos, Universidade Estadual do Piauí (UESPI), Teresina, PI, Brazil.

Medical doctor at State University of Piauí (UESPI), Teresina, PI, Brazil.

Rafael Everton Assunção Ribeiro da Costa, Universidade Estadual do Piauí (UESPI), Teresina, PI, Brazil.

Medical student at State University of Piauí (UESPI), Teresina, PI, Brazil.

Eduardo Salmito Soares Pinto, Secretaria de Saúde do Estado do Piauí (Sesapi), Teresina, PI, Brazil.

Resident doctor at Getúlio Vargas Hospital, Teresina, PI, Brazil.

Ana Luisa Rios Barbosa de Almeida, Hospital São Marcos (HSM), Teresina, PI, Brazil; Associação Piauiense de Combate ao Câncer Alcenor Almeida, Teresina, PI, Brazil.

Specialization in Buco-Maxillo-Facial Surgery and Traumatology; specialization in Stomatology; coordinator of the Dental Service in São Marcos Hospital, Teresina, PI, Brazil.

Cacilda Castelo Branco Lima, Universidade Federal do Piauí (UFPI), Teresina, PI, Brazil.

PhD in Dentistry from the University of Minas Gerais (UFMG), Belo Horizonte, MG, Brazil; Professor at the Federal University of Piauí (UFPI), Teresina, PI, Brazil.

Luciana Tolstenko Nogueira, Universidade Estadual do Piauí (UESPI), Teresina, PI, Brazil.

PhD in Dental Clinics from the Faculty of Dentistry São Leopoldo Mandic (SLMANDIC), Campinas, SP, Brazil; Professor at State University of Piauí (UESPI), Teresina, PI, Brazil.

Lucielma Salmito Soares Pinto, Universidade Estadual do Piauí (UESPI), Teresina, PI, Brazil.

PhD in Stomatopathology from the University of Campinas (Unicamp), Campinas, SP, Brazil; Professor at State University of Piauí (UESPI), Teresina, PI, Brazil.

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Published

2021-10-29

How to Cite

Rocha, C. E. M. C., Santos, J. C. S., Costa, R. E. A. R. da, Pinto, E. S. S., Almeida, A. L. R. B. de, Lima, C. C. B., Nogueira, L. T., & Pinto, L. S. S. (2021). Prognostic factors and long-term survival in oral squamous cell carcinoma: A cross-sectional study. Scientia Medica, 31(1), e41124. https://doi.org/10.15448/1980-6108.2021.1.41124

Issue

Vol. 31 No. 1 (2021): Single Volume

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Research Article

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