Prevalence of extended-spectrum beta-lactamases in Klebsiella pneumoniae and Escherichia coli bacteremia <b>[Abstract in English]</b>
Keywords:
Beta-lactamases de espectro estendido, bacteremia, infecção hospitalarAbstract
Aims: To evaluate the prevalence of extended-spectrum beta-lactamases (ESBL) production by Klebsiella pneumoniae and Escherichia coli isolated from hospitalized adult patients and to describe the patient's clinical characteristics. Methods: Through a cross-sectional study, all charts from adult patients that presented Klebsiella pneumoniae and Escherichia coli bacteremia in Hospital São Lucas da PUCRS, from June 2004 to March 2006, were revised. Results: A total of 145 patients were included in the study. Among them, 51 (35.2%) had an isolate of ESBL-producing bacteria. The prevalence of ESBL was higher in Klebsiella pneumoniae (45 isolates, 55.6%) than in Escherichia coli (6 isolates, 9.4% p<0.001). The use of betalactamic antibiotics in the previous 14 days was commonest in the group ESBL-producing (50 pacients, 98%) than in the group no ESBL-producing (15 pacients, 16%); p<0.001. Imipenem was the drug with better in vitro efficacy against ESBL-producing isolates (100%). Conclusions: The study demonstrated a high prevalence of ESBL-producing K. pneumoniae bacteremias. Patients with bacteremia by ESBL-producing isolates had higher mortality, and previous use of betalactamic antibiotics was stongly associated to this enzyme production. Continuous surveillance of ESBL-producing Enterobacteriacae prevalence is necessary for definition of therapeutic measures and infection control policies. KEYWORDS: BETA-LACTAMASES; BACTEREMIA; CROSS INFECTION.Downloads
Downloads
Published
How to Cite
Issue
Section
License
Copyright
The submission of originals to Scientia Medica implies the transfer by the authors of the right for publication. Authors retain copyright and grant the journal right of first publication. If the authors wish to include the same data into another publication, they must cite Scientia Medica as the site of original publication.
Creative Commons License
Except where otherwise specified, material published in this journal is licensed under a Creative Commons Attribution 4.0 International license, which allows unrestricted use, distribution and reproduction in any medium, provided the original publication is correctly cited.