Continuous versus pulsed ultrasound in the release of hydrocortisone in vitro Claudia

Authors

  • Claudia Regina Pretto Universidade do Vale do Taquari
  • Barbara Scmitt Universidade do Vale do Taquari
  • Giovana Sinigaglia Universidade do Vale do Taquari http://orcid.org/0000-0002-4614-3272
  • Paula Bianchetti Universidade do Vale do Taquari
  • João Alberto Fioravante Tassinary Universidade do Vale do Taquari
  • Mauricio Hillgemann Universidade do Vale do Taquari
  • Simone Stulp Universidade do Vale do Taquari

DOI:

https://doi.org/10.15448/1983-652X.2018.3.29926

Keywords:

ultrasound, phonophoresis, in vitro technique.

Abstract

Introduction: Phonophoresis is based on the disruption of tissue that generates fast moving particles, facilitating drug absorption.
Objective: The aim of this study is to measure the release of hydrocortisone by the application of in vitro phonophoresis in continuous and pulsed mode.
Materials and Methods: In order to perform the evaluations, hydrocortisone in gel, manipulated in compounding pharmacy, was used. Analysis were made in cellulose acetate membrane associated with hydrocortisone with and without the application of phonophoresis, applying continuous and pulsed ultrasound at the 0, 5, 10, 15 and 20 minute application times. The analyzes were performed in triplicate.
Results: The results suggest a greater release of hydrocortisone when associated to the therapeutic sonic wave. It was also found that the ultrasound in the continuous mode is more effective when compared to the pulsed mode after 5 minutes of application. At 10, 15 and 20 minutes the ultrasound adjusted in the continuous mode was more effective. Drug release has increased, when compared to the pulsed mode, in 585, 302 and 260%, respectively.
Conclusion: Continuous-mode ultrasound is more effective when compared to pulsed mode at 5%, from 5 minutes of application, for release and permeation of 1% hydrocortisone in a vertical diffusion system.

Author Biographies

Claudia Regina Pretto, Universidade do Vale do Taquari

Graduação em Fisioterapia

Barbara Scmitt, Universidade do Vale do Taquari

Graduada em Biomedicina

Giovana Sinigaglia, Universidade do Vale do Taquari

Mestre, professora do Centro de Ciências Biológicas e da Saúde- Univates

Paula Bianchetti, Universidade do Vale do Taquari

Mestre, professora do Centro de Ciências Biológicas e da Saúde da Univates

João Alberto Fioravante Tassinary, Universidade do Vale do Taquari

Doutor, professor do Centro de Ciências Biológicas e da Saúde da Univates

Mauricio Hillgemann, Universidade do Vale do Taquari

Doutor, professor do programa de Pós Graduação em Ambiente e Desenvolvimento da Univates

Simone Stulp, Universidade do Vale do Taquari

Doutora, professor do programa de Pós Graduação em Ambiente e Desenvolvimento da Univates

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Published

2018-10-17

Issue

Vol. 11 No. 3 (2018)

Section

Original Articles

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