Effect of neurotrophic factors on peripheral nerve repair <b>[Abstract in English]</b>

  • Alessandra Deise Sebben PUCRS
  • Fernanda Cocolichio PUCRS
  • Ana Paula Schmitt PUCRS
  • Mariana Dias Curra PUCRS
  • Paloma Viegas FEEVALE/PUCRS
  • Guilherme Leví Tres PUCRS
  • Jefferson Luís Braga Silva PUCRS
Keywords: BIOMATERIALS, NERVE REGENERATION, GROWTH FACTORS.

Abstract

Aims: This review aimed to analyze and discuss studies about the main growth factors tested in vitro and in vivo on peripheral nerves regeneration. Source of data: Articles were selected from the databases LILACS, Medline, and SciELO, using the following key words: nerve regeneration, nerve growth factor, brain-derived neurotrophic factor, neurotrophin 3, neurotrophin 4/5, ciliary neurotrophic factor, glial cell line-derived neurotrophic factor, vascular endothelial growth factor, insulin-like growth factor, peripheral nervous system, injury, sensory neurons, motor neurons, autologous graft, and rats. Summary of findings: Several trophic factors, also known as growth factors, are used and tested in vitro and in vivo regeneration of peripheral nerves. These proteins act directly on the proliferation and differentiation of different cell types, being able to promote tissue repair and functional recovery. Usually the ideal model for the application of these substances is a continuous delivery system via biodegradable conduits. Conclusions: It is possible to conclude that the combination of two or more growth factors probably exercise a synergistic effect on nerve regeneration, especially when associated with absorble biomaterials with controlled release. Although the knowledge obtained about these proteins indicate an improvement in nerve regeneration, further experimental studies are needed before transpose them into clinical application.

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Author Biographies

Alessandra Deise Sebben, PUCRS
Bióloga, MSc em Ciências da Saúde. Bolsista de doutorado do PPG em Medicina e Ciências da Saúde da PUCRS. Laboratório de Habilidades Médicas e Pesquisa Cirúrgica da PUCRS.
Fernanda Cocolichio, PUCRS
Graduanda em Medicina da PUCRS, bolsista de iniciação científica. Laboratório de Habilidades Médicas e Pesquisa Cirúrgica da PUCRS.
Ana Paula Schmitt, PUCRS
Graduanda emMedicina da PUCRS. Laboratório de Habilidades Médicas e Pesquisa Cirúrgica da PUCRS.
Mariana Dias Curra, PUCRS
Graduanda em Medicina da PUCRS, bolsista de apoio técnico do Laboratório de Habilidades Médicas e Pesquisa Cirúrgica da PUCRS.
Paloma Viegas, FEEVALE/PUCRS
Graduanda emBiomedicina da FEEVALE. Bolsista de Iniciação científica do Laboratório de Habilidades Médicas e Pesquisa Cirúrgica.
Guilherme Leví Tres, PUCRS
Graduando em Medicina da PUCRS.
Jefferson Luís Braga Silva, PUCRS
Livre-Docente, UNIFESP. Professor do Departamento de Cirurgia, FAMED, PUCRS. Chefe do Serviço Cirurgia da Mão e Microcirurgia Reconstrutiva do Hospital São Lucas, PUCRS. Ex-Presidente da Sociedade Brasileira de Cirurgia da Mão. Ex- Presidente da Sociedade Brasileira de Microcirurgia Reconstrutiva.
Published
2011-07-01
How to Cite
Sebben, A. D., Cocolichio, F., Schmitt, A. P., Curra, M. D., Viegas, P., Tres, G. L., & Braga Silva, J. L. (2011). Effect of neurotrophic factors on peripheral nerve repair <b>[Abstract in English]</b>. Scientia Medica, 21(2), 81-89. Retrieved from https://revistaseletronicas.pucrs.br/ojs/index.php/scientiamedica/article/view/8946
Section
Review Articles