Effects of regular physical exercise on skin blood flow and cardiovascular risk factors in overweight and obese subjects

Keywords: laser-doppler flowmetry, nitric oxide, omentin, obesity, physical exercise

Abstract

Objective: it is well known that low omentin levels and reduced bioavailability of nitric oxide (NO) are outgrowth of obesity. Besides, in obese subjects, microvascular dysfunction can be an initial stage of cardiovascular diseases. This situation can be evaluated with skin laser–Doppler flowmetry (LDF).
Methods: in this study we investigated the effects of 12 weeks moderate physical exercise on microvascular reactivity and plasma levels of omentin and NO in 25 overweight and obese subjects. Control group was composed of 28 sedentary participants who were neither obese nor overweight. Microvascular reactivity was handled by measurement of skin blood flow from the ring finger of the right hand with LDF, which is a non–invasive method for evaluation. With this method, it was aimed to examine the post–occlusive reactive hyperemia response of the patients. None of the participants in both groups have never followed a regular exercise schedule in their life span.
Results: with regular exercise, there was a statistically significant decrease in glucose (p=0.008), cholesterol (p=0.05), and triglyceride (p=0.048) levels, while body mass index, high–density lipoprotein, and low–density lipoprotein levels did not change significantly in overweight/obese group. Also, the omentin level significantly increased (p=0.01), but NO level did not change significantly. Moreover, the amount of change in omentin and NO levels measured before and after the physical exercise were significantly correlated (r=0.57). Considering the microcirculation, rest flow (p=0.001) and peak flow value of LDF (p=0.001) increased after the physical exercise.
Conclusion: our study shows that moderate physical exercise affects microvascular reactivity and plasma levels of omentin in overweight and obese subjects.

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Author Biographies

Tuğba Kılıç, Gaziantep University (GAUN), Faculty of Medicine, Physiology Department, Gaziantep, Turkey.

PhD in Physiology Department of Faculty of Medicine of Gaziantep University (GAUN), Gaziantep, Turkey. Practitioner/Clinician in Tuğba Beauty Centre in Gaziantep, Turkey. Graduated from Atatürk University (ATAUNI), Faculty of Medicine, Erzurum, Turkey.

Cahit Bağcı, Sakarya University (SAU), Faculty of Medicine, Physiology Department, Sakarya, Turkey.

PhD in Physiology Department of Graduate School of Health Science of Ankara University, Turkey. Graduated from Ankara University (AU), Faculty of Veterinary Science, Ankara, Turkey. Professor at Physiology Department of Faculty of Medicine of Gaziantep University (GAUN), Turkey. Professor at Physiology Department of Faculty of Medicine of Sakarya University (SU), Turkey.

Mehmet Göl, Gaziantep Islam Science and Technology University (GIBTU), Faculty of Medicine, Department of Medical Physiology, Gaziantep, Turkey.

PhD in Physiology Department of Faculty of Medicine of Gaziantep University (GAUN), Ankara, Turkey. Graduated from Hacettepe University (HU), Faculty of Medicine, Ankara, Turkey. Assistant Professor at Physiology Department of Faculty of Medicine of Gaziantep Islam Science and Technology University (GIBTU), Gaziantep, Turkey.

Hakim Çelik, Harran University (HRU), Faculty of Medicine, Physiology Department, Şanlıurfa, Turkey.

PhD in Physiology Department of Faculty of Medicine of Gaziantep University (GAUN), Gaziantep, Turkey. Master degree in Biochemistry Department of Graduate School of Health Science of Harran University, Şanlıurfa Turkey. Graduated from Harran University (HRU), Biology Department of Faculty of Arts and Science, Şanlıurfa, Turkey. Associate Professor at Physiology Department of Faculty of Medicine of Harran University, Turkey.

Davut Sinan Kaplan, Gaziantep University (GAUN), Faculty of Medicine, Physiology Department, Gaziantep, Turkey.

PhD in Physiology Department of Faculty of Medicine of Gaziantep University (GAUN), Turkey. Graduated from Fırat University (FU), Faculty of Veterinary Science, Elazığ, Turkey. Associate Professor at Physiology Department of Faculty of Medicine of Gaziantep University, Gaziantep Turkey.

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Published
2022-05-16
How to Cite
Kılıç, T., Bağcı, C., Göl, M., Çelik, H., & Kaplan, D. S. (2022). Effects of regular physical exercise on skin blood flow and cardiovascular risk factors in overweight and obese subjects. Scientia Medica, 32(1), e41980. https://doi.org/10.15448/1980-6108.2022.1.41980