Plasma antioxidant substances apparently do not influence the radiodermatitis occurrence

Keywords: Breast cancer, Oxidative stress, Radiotherapy, Thiobarbituric acid reactive substances, Radiodermatitis

Abstract

AIMS: Radiation affects not only tumors but also healthy tissues through the increment of oxidative stress. Thus, this study aimed to evaluate the oxidative stress degree as well as non-enzymatic antioxidant defenses in the plasma of patients submitted to radiotherapy and to verify if these parameters are modified in those patients who develop radiodermatitis.
METHODS: Forty-one patients submitted to radiotherapy for treatment of breast cancer were followed. From these patients, plasma samples were obtained at the beginning, in the middle and at the end of the treatment, for analysis of thiobarbituric acid reactive substances (TBARS) and ferric reducing ability of plasma (FRAP).
RESULTS: No significant differences were observed in terms of TBARS and FRAP in plasma harvested from these patients at the beginning and at the middle of the treatment. There was lower incidence of grade two radiodermatitis among patients undergoing radiotherapy with hypofractionated doses. There were no differences in FRAP or TBARS among patients who developed radiodermatitis of any degree in relation to those who did not develop this side effect. No differences of FRAP or TBARS were observed between patients that presented grade two radiodermatitis regarding to the others studied.
CONCLUSION: There was no clear relationship between changes in TBARS or FRAP with the occurrence or severity of radiodermatitis.

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Author Biographies

Guilherme Costa Munhoz, Faculdade de Medicina de Marília (FAMEMA). Marília, SP

Master in Health and Aging by the Marilia Medical School (FAMEMA, Marília, SP, Brazil), professor of Internal Medicine at Clinic Hospital of Marilia Medical School (HC-FAMEMA, Marília, SP, Brazil).

Gustavo Viani Arruda, Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (FMRP-USP). Ribeirão Preto, SP

PhD in Medicine and professor of Radiotherapy at Ribeirão Preto Medical School (FMRP-USP, Ribeirão Preto, SP, Brazil).

Marcela Maris Madeira Lana Soares, Faculdade de Medicina de Marília (FAMEMA). Marília, SP

Master in Health Education by the Marilia Medical School (FAMEMA, Marília, SP, Brazil), nurse at Department of Radiation Oncology of Clinic Hospital of Marilia Medical School (HC-FAMEMA, Marília, SP, Brazil).

Dayanne Guttmann Batista, Faculdade de Medicina de Marília (FAMEMA). Marília, SP

Resident of Physical Medicine and Rehabilitation at Clinic Hospital of Marilia Medical School (HC-FAMEMA, Marília, SP, Brazil).

Agnaldo Bruno Chies, Faculdade de Medicina de Marília (FAMEMA). Marília, SP

PhD in Pharmacology by the Ribeirão Preto Medical School (FMRP-USP, Ribeirão Preto, SP, Brazil), professor of Pharmacology and Experimental Therapeutics at Marília Medical School (FAMEMA, Marília, SP, Brazil).

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Published
2020-09-17
How to Cite
Munhoz, G. C., Viani Arruda, G., Maris Madeira Lana Soares, M., Guttmann Batista, D., & Chies, A. B. (2020). Plasma antioxidant substances apparently do not influence the radiodermatitis occurrence. Scientia Medica, 30(1), e35844. https://doi.org/10.15448/1980-6108.2020.1.35844
Section
Original Articles