Acute effect of the antioxidant drug U-74389G on hematocrit levels during hypoxia and reoxygenation injury in rats


  • Constantinos Tsompos
  • Constantinos Panoulis
  • Konstantinos Toutouzas
  • Aggeliki Triantafyllou
  • George Zografos
  • Apostolos Papalois



hipóxia, reoxigenação, hematócrito, U-74389G, modelos animais.


Efeito agudo do fármaco antioxidante U-74389G sobre os níveis de hematócrito durante a lesão induzida por hipóxia e reoxigenação em ratos

Objetivos:Este estudo experimental avaliou o efeito da droga antioxidante U-74389G nos níveis de hematócrito, utilizando um modelo murino de hipóxia e reoxigenação, de acordo com um protocolo estabelecido.

Métodos: Quarenta ratos com um peso médio de 231,875 g foram utilizados no estudo. Os níveis de hematócrito foram determinados aos 60 min (grupos A e C) e aos 120 minutos (grupos B e D) após o início da reoxigenação. Os grupos A e B não receberam nenhuma droga, enquanto que a U-74389G foi administrada aos ratos dos Grupos C e D.

Resultados: A administração de U-74389G aumentou significativamente os níveis de hematócrito em 4,73%±2,25% (p=0,0435). O tempo de reoxigenação aumentou não significativamente os níveis de hematócrito em 3,96%±2,29% (p=0,1025). Aadministração de U-74389G combinada com o tempo de reoxigenação aumentou significativamente os níveis de hematócrito em 3,16%±1,33 (p=0,0196).

Conclusões: A administração de U-74389G, quer interagindo ou não com o tempo de reoxigenação, aumentou significativamente, no curto prazo, os níveis de hematócrito em um modelo murino de hipóxia e reoxigenação.


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Como Citar

Tsompos, C., Panoulis, C., Toutouzas, K., Triantafyllou, A., Zografos, G., & Papalois, A. (2016). Acute effect of the antioxidant drug U-74389G on hematocrit levels during hypoxia and reoxygenation injury in rats. Scientia Medica, 26(1), ID21797.



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