Fatores reguladores da osteoclastogênese (RANK, RANKL e OPG) em lesões osteolíticas da maxila

Autores

  • Maiara de Moraes
  • Felipe Rodrigues de Matos
  • Antonio de Lisboa Lopes Costa

Palavras-chave:

Osteoclastogênese, RANKL, RANK, OPG,

Resumo

Receptor activador do factor nuclear kB (RANK), ligante de RANK (RANKL) e osteoprotegerina (OPG), são membros da superfamília de ligantes e receptores do fator de necrose tumoral relacionados com o metabolismo ósseo. A osteoclastogênese é regulada por estas três proteínas. O objetivo desta revisão foi avaliar a expressão imuno-histoquímica destas proteínas em lesões osteolíticas dos maxilares. Os estudos foram identificados através de pesquisa MEDLINE/PubMed. Os resultados revelaram maior imunoexpressão para RANKL em relação a OPG em periodontites crônicas e em tumores odontogênicos agressivos, já em tumores menos agressivos houve uma tendência de maior expressão para OPG. Levando em conta estes achados, a OPG poderia ser um bom candidato para o tratamento de lesões maxilares que podem muitas vezes ser amplamente destrutivas.

Biografia do Autor

Maiara de Moraes

 

 

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Publicado

2013-10-28

Edição

Seção

Revisão de Literatura