Effect of chronic stress on the repair of cutaneous wounds in rats

Authors

  • Alex Semenoff Segundo UNIC
  • Tereza A. Delle Vedove Semenoff UNESP
  • Eder Ricardo Biasoli
  • Samyra Lopes Buzelle UFMT
  • Suellen Lara Guirra Rosa UFMT

Keywords:

stress, wound healing, rats

Abstract

Purpose: The aim of this study was to determine the effect of different types of chronic stress on the contraction of cutaneous wounds on the back of rats. Methods: Nineteen rats were randomly divided into two groups: chronic stress - GCS (n=9) and control – GC (n=10). The GCS were subjected to testing of chronic stress (exposure to light flashing, isolation, crowded environment, noise and smell of blood) throughout the experiment for a period of 10 days. The animals were anesthetized, and a surgical wound with area of 1 cm2 was made on the back of each animal, preserving the muscle tissue. The measurements of the wounds were made by a blinded examiner at 3, 7 and 12 days after surgery, using a digital caliper. The contraction of the wound was measured using the following formula: (initial area – area on the day of measurement) / initial area × 100 = percentage of wound contraction. Data were analyzed by Student t test for independent samples. Results: The results showed a lower rate of wound contraction in stressed animals at 7 and 12 days after surgery in comparison with the control group. Conclusion: Based on the methods and the animal model used, it was possible to conclude that rats subjected to chronic stress have delayed wound contraction during repair.

Author Biographies

Alex Semenoff Segundo, UNIC

Professor Doutor da Universidade de Cuiabá – Odontologia em âmbito hospitalar e Periodontista do Centro de Especialidades Odontológicas para Pacientes Especiais – CEOPE/MT

Tereza A. Delle Vedove Semenoff, UNESP

Doutoranda do Programa de Pós-Graduação em Odontologia Área de Concentração Estomatologia da UNESP - Campus Araçatuba.

Samyra Lopes Buzelle, UFMT

Mestranda em Biociências da Universidade Federal do Estado de Mato Grosso

Suellen Lara Guirra Rosa, UFMT

Mestranda em Biociências da Universidade Federal do Estado de Mato Grosso

Downloads

Published

2009-02-11

Issue

Vol. 24 No. 2 (2009)

Section

Original Article

License

COPYRIGHT
The submission of originals to Odonto Ciência implies the transfer by the authors of the right for publication. Authors retain copyright and grant the journal right of first publication. If the authors wish to include the same data into another publication, they must cite Odonto Ciência as the site of original publication.

CREATIVE COMMONS LICENSE
As this journal is open access, the articles are allowed free use in scientific and educational applications, with citation of the source.
According to the type of Creative Commons License (CC-BY 4.0) adopted by Odonto Ciência, the user must respect the requirements below.

You are free to:
Share — copy and redistribute the material in any medium or format.
Adapt — remix, transform, and build upon the material for any purpose, even commercially.

However, only under the following terms:
Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests Odonto Ciência endorses you or your use.
No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

Notices:
You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation.
No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.

For more details on the Creative Commons license, please follow the link in the footer of this website.