Influence of fruit juices on bioavailability and half-life of drugs

Authors

  • Rosane Maria Salvi PUCRS
  • Caroline de Oliveira Riella
  • Cristine Saldanha Souto
  • Juliana Krunitzki Bueno
  • Rosane Ramos Guimarães
  • Carolina Mariante de Abreu

DOI:

https://doi.org/10.15448/1983-652X.2010.1.6380

Keywords:

interactions, juices, cytochrome P-450 enzyme system, P-Glycoproteins.

Abstract

Administering medications together with fruit juices may lead to variations in pharmacokinetics and pharmacodynamics, with repercussions on the bioavailability and half –life of the compounds. Pharmacokinetic mechanisms are usually related to intestinal and hepatic enzymes of cytochrome P-450 (CYP 450) interference, as well as in transporter enzymes of the mucosa (P-glycoproteín, organic anion transporter polypeptide - OATP). Based on the data above, the aforementioned article seeks information on interaction events involving the co-administration of medications and fruit juices. The review was based on research performed in different databases and related books. The results showed a significant number of interactions, identified in experimental studies, cases-controls and case report. References to the potentiation of an effect, or to therapeutic inefficacy, as a result of the association of pharmaceuticals with fruit juice, were mentioned by several authors, which justify the relevance of diagnosing these phenomenon.

Author Biographies

Rosane Maria Salvi, PUCRS

Rosane Maria Salvi, Médica, Doutora em Ciências Biológicas - Área Neurociências, Professor Adjunto da FABIO, Disciplinas de Farmacologia e Toxicologia, Coordenadora do Curso de Especialização em Toxicologia Aplicada

Caroline de Oliveira Riella

Nutricionista Formada pela PUCRS

Cristine Saldanha Souto

Nutricionista Formada pela PUCRS

Juliana Krunitzki Bueno

Nutricionista Formada pela PUCRS

Rosane Ramos Guimarães

Nutricionista Formada pela PUCRS

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Published

2011-01-12

Issue

Vol. 3 No. 1 (2010)

Section

Review Articles

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