Does ginger have an effect on nausea and vomiting in patients undergoing chemotherapy?
DOI:
https://doi.org/10.15448/1983-652X.2018.3.30223Keywords:
ginger, nausea, vomiting, neoplasms, chemotherapy.Abstract
Introduction: The ginger has a potential antiemetic effect, but there are few studies which investigate its effects on patients undergoing chemotherapy.
Objective: To evaluate the effect of ginger on the control of nausea and vomiting in patients undergoing chemotherapy.
Materials and Methods: This is a clinical, randomized, triple-blind, placebo-controlled, and crossover trial. Sixteen patients were recruited, of whom 12 completed the study. Subjects were randomly assigned to receive 1 g of a ginger dry extract or placebo four days before and after chemotherapy. The nutritional status was evaluated by the Global Subjective Evaluation Produced by the Patient. The instrument for measuring the main outcome was the Multinational Association on Suportive Care in Cancer. The effects were evaluated by the Wilcoxon test for the ordinal variables and by the McNemar test for the qualitative variables.
Results: When the ginger group was compared to the placebo group, there were no difference in the number of episodes of acute and late vomiting, the intensity of late nausea, the occurrence of acute and late nausea and the occurrence of acute and late vomiting. The groups differed in acute nausea, which were lower in the placebo group.
Conclusion: Supplementation with ginger is not effective to prevent nausea and vomiting induced by chemotherapy.
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