Atividade Anti-Staphylococcus aureus Meticilina Resistente (MRSA) de um novo composto 3-Calcogenil Indol

Autores

DOI:

https://doi.org/10.15448/1980-6108.2021.1.41325

Palavras-chave:

anti-MRSA, chalcogenil-indóis, novos antimicrobianos, ensaios de curva de morte, Staphylococcus aureus

Resumo

Objetivo: o desenvolvimento de novos antimicrobianos contra Staphylococcus aureus resistentes à meticilina (MRSA) é uma prioridade para a Organização Mundial da Saúde. Então, o objetivo desse estudo foi avaliar a atividade antibacteriana e a toxicidade do 5-bromo-3-((4-metoxifenil) sulfenil)-1H-indol (3b) contra MRSA.
Métodos: a concentração inibitória minima de 3b foi determinada contra S. aureus ATCC 29213 e 43 isolados clínicos. O ensaio de curva de morte foi realizado para nove isolados. Análise de variância seguida pelo teste post hoc Bonferroni foi usada para testes estatísticos.
Resultados e conclusões: a MIC50 e MIC90 do 3b foi 4 μg.mL-1 e 16 μg.mL-1, respectivamente. No ensaio de curva de morte, o 3b demonstrou atividade bactericida contra todos os isolados avaliados na concentração de 1xMIC e 2xMIC e o recrescimento não foi observado. Em relação aos testes de toxicidade, 3b não apresentou citotoxicidade, mutagenicidade ou alergenicidade. 3b apresentou atividade particularmente interessante contra MRSA, demonstrando alto potencial para o desenvolvimento de novos produtos antimicrobianos.

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Biografia do Autor

Laisa Borges Ferreira, Federal University of Rio Grande do Sul (UFRGS).

Master in Agricultural and environmental Microbiology, Institute of Health Sciences, Federal University of Rio Grande do Sul (UFRGS), in Porto Alegre, RS, Brazil. Clinical Research coordinator at Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil.

Edilma Elayne da Silva, Federal University of Rio Grande do Sul (UFRGS).

Master in Chemistry, Federal University of Pernambuco, RE, Brazil. Doctorate Student in Organic chemistry, Institute of Chemistry (IQ), Federal University of Rio Grande do Sul (UFRGS), in Porto Alegre, RS, Brazil.

Silvia Adriana Meyer Lentz, Federal University of Rio Grande do Sul (UFRGS).

Master in Agricultural and Environmental Microbiology, Institute of Health Sciences, Federal University of Rio Grande do Sul (UFRGS), in Porto Alegre, RS, Brazil. Doctorate student at in Agricultural and Environmental Microbiology, Institute of Health Sciences, Federal University of Rio Grande do Sul (UFRGS), in Porto Alegre, RS, Brazil.

Juliano Braun de Azeredo, Federal University of Rio Grande do Sul (UFRGS).

PhD and Master in Organig Chemistry, Federal University of Santa Catarina (UFSC), in Florianópolis, SC, Brazil. Professor at Organic Chemistry and Pharmacognosy Laboratory, Federal University of Pampa (UNIPAMPA), in Uruguaiana, RS, Brazil.

Antonio Luiz Braga, Federal University of Rio Grande do Sul (UFRGS).

PhD and Master in Organig Chemistry, Federal University of São Paulo (UNIFESP), in São Paulo, SP, Brazil. Professor at Chemistry department, Federal University of Santa Catarina (UFSC), in Florianópolis, SC, Brazil.

Michel Mansur Machado, Federal University of Rio Grande do Sul (UFRGS).

PhD in Biological Science, Federal University of Santa Maria (UFSM), in Santa Maria, RS, Brazil. Master in Pharmaceutical Science, Federal University of Santa Maria (UFSM), in Santa Maria, RS, Brazil. Professor at Clinical Immunology and Toxicology Laboratory, Federal University of Pampa (UNIPAMPA), in Uruguaiana, RS, Brazil.

Mario Lettieri Teixeira, Federal University of Rio Grande do Sul (UFRGS).

PhD and Master in Molecular and Cellular Biology, Federal University of Rio Grande do Sul (UFRGS), in Porto Alegre, RS, Brazil. Professor at Federal Institute of Santa Catarina, in Concórdia, SC, Brazil.

Juliana Caierão, Federal University of Rio Grande do Sul (UFRGS).

PhD in Science, Federal University of Rio de Janeiro (UFRJ), in Rio de Janeiro, RJ, Brazil. Master in Medical Science, Federal University of Health Science of Porto Alegre, in Porto Alegre, RS, Brazil (UFCSPA). Professor at Postgraduate Program in Pharmaceutical Sciences, Federal University of Rio Grande do Sul, in Porto Alegre, RS, Brazil.

Gustavo Pozza Silveira, Federal University of Rio Grande do Sul (UFRGS).

Doctor in Chemistry, Federal University of Santa Catarina (UFSC), in Florianópolis, SC, Brazil. Professor at Federal University of Rio Grande do Sul (UFRGS), in Porto Alegre, RS, Brazil.

Andreza Francisco Martins, Federal University of Rio Grande do Sul (UFRGS).

Doctor in Medical Science, Federal University of Rio Grande do Sul (UFRGS), in Porto Alegre, RS, Brazil. Master in Pharmaceutical Science, Federal University of Rio Grande do Sul (UFRGS), in Porto Alegre, RS, Brazil. Professor at Federal University of Rio Grande do Sul (UFRGS), in Porto Alegre, RS, Brazil.

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Publicado

2021-12-20

Como Citar

Ferreira, L. B., Silva, E. E. da, Lentz, S. A. M., Azeredo, J. B. de, Braga, A. L., Machado, M. M., Teixeira, M. L., Caierão, J., Silveira, G. P., & Martins, A. F. (2021). Atividade Anti-Staphylococcus aureus Meticilina Resistente (MRSA) de um novo composto 3-Calcogenil Indol. Scientia Medica, 31(1), e41325. https://doi.org/10.15448/1980-6108.2021.1.41325

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Artigo de Pesquisa