Postmenopausal women with high TNF-α concentrations presented less reduction in fat and blood lipids

A randomized controlled clinical trial

Keywords: weight loss, inflammation, high-protein, physical conditioning


Aims: evaluate the effects of a high-protein diet associated with physical exercise on inflammatory markers and body composition. 
Methods: the study is a 12-week clinical trial of 26 postmenopausal women who received an individualized high-protein food plan and participated in three multicomponent training sessions each week. Food intake was monitored through eight 24-hour food recalls, and the habitual food intake was estimated. At the beginning and end of the study, anthropometric variables were measured; fat content and lean mass were estimated using formulas, and blood was collected for C-reactive protein (CRP) quantification, including TNF-α, IL-6, IL-10, and IL-18. One-way ANOVA was performed.
Results: it was identified that 13 participants had a high-protein (HP) diet and 13 had a standard-protein (SP) diet. The HP group lost weight (p = 0.032); however, there were no changes in the fat content, the lean mass content, or the inflammatory markers. Only women who started the program with lower TNF-α values showed significant loss of total fat (p = 0.049), visceral fat (p = 0.037), triglycerides (p = 0.031), and LDL cholesterol (p = 0.003). 
Conclusion: postmenopausal women with high concentrations of inflammatory markers are less responsive to strategies for modifying body composition. 


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Author Biographies

Jamylle Araújo Almeida, Universidade Federal de Sergipe, São Cristóvão, SE, Brasil.

Mestre em Ciências da Nutrição e graduada em Nutrição pela Universidade Federal de Sergipe (UFS), em São Cristóvão, SE, Brasil. 

Liliane Viana Pires, Universidade Federal de Sergipe, São Cristóvão, SE, Brasil.

Mestre em Ciências da Nutrição e graduada em Nutrição pela Universidade Federal de Sergipe (UFS), em São Cristóvão, SE, Brasil.

Luana Edla Lima, Universidade Federal de Sergipe, São Cristóvão, SE, Brasil.

Mestre em Ciências da Nutrição e graduada em Nutrição pela Universidade Federal de Sergipe (UFS), em São Cristóvão, SE, Brasil.

Francismayne Batista Santana, Universidade Federal de Sergipe, São Cristóvão, SE, Brasil.

Especialista em Saúde do Adulto e do Idoso e graduada em Nutrição pela Universidade Federal de Sergipe (UFS), em São Cristóvão, SE, Brasil.

Walderi Monteiro da Silva Júnior, Universidade Federal de Sergipe, São Cristóvão, SE, Brasil.

Doutor em Clínica Médica pela Universidade Federal do Rio de Janeiro (UFRJ), no Rio de Janeiro, RJ, Brasil. Mestrado em Engenharia Biomédica e graduado em fisioterapia pela Universidade Federal da Paraíba. Professor Associado da Universidade Federal de Sergipe (UFS), em São Cristóvão, SE, Brasil.

Marzo Edir da Silva Grigoletto, Universidade Federal de Sergipe, São Cristóvão, SE, Brasil.

Doutor em “Ciencias Aplicadas a la Actividad Física y el Deporte” pela Universidad de Córdoba, com pós-doutorado no Hospital Reina Sofia. Professor da Universidade Federal de Sergipe, em São Cristóvão, SE, Brasil.

Raquel Simões Mendes Netto, Universidade Federal de Sergipe, São Cristóvão, SE, Brasil.

Doutora e mestre em Ciências dos Alimentos pela Universidade de São Paulo (USP), em São Paulo, SP, Brasil. Graduada em Nutrição pela Universidade Federal de Pernambuco. Professora associada da Universidade Federal de Sergipe (UFS), em São Cristóvão, SE, Brasil.


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How to Cite
Almeida, J. A., Pires, L. V., Lima, . L. E., Santana, F. B., Júnior, W. M. da S., Grigoletto, M. E. da S., & Netto, R. S. M. (2022). Postmenopausal women with high TNF-α concentrations presented less reduction in fat and blood lipids: A randomized controlled clinical trial. PAJAR - Pan American Journal of Aging Research, 10(1), e42759.