Influence of immunosuppressants on bone metabolism and tooth movement: A literature review

Authors

  • Rogério Lacerda dos Santos UFRJ
  • Renato Torres Gonçalves UFRJ
  • Marco Aurélio Martins FIOCRUZ-RJ
  • Margareth Maria Gomes de Souza UFRJ

Keywords:

Immunosuppressant, tooth movement, bone

Abstract

The objective of this literature review is to discuss the influence of immunosuppressants on bone metabolism and tooth movement in Orthodontics. Tooth movement occurs as a result of bone and periodontal ligament remodeling. Some medications such as immunosupressants can affect bone metabolism and the rate of tooth movement. Immunosupressants act by repressing the action of T lymphocytes, may cause bone loss, and lead to osteoporosis, which is a common complication following kidney, heart, liver, or lung transplantation. The use of immunosuppressants to prevent rejection after organ transplantation includes glucocorticoids, cyclosporine A, tacrolimus, and sirolimus, which may cause damaging effects on the bone mineral homeostasis. Tooth movement depends on orthodontic force, dosage, and duration of immunosuppressive therapy, and individual response of each patient. Therefore, all patients who have received transplants should be closely monitored to prevent bone loss before and during orthodontic treatment. Key words: Immunosuppressant; tooth movement; bone

Author Biographies

Rogério Lacerda dos Santos, UFRJ

Especialista em Ortodontia-UNIFAL Mestrando em Ortodontia-UFRJ

Renato Torres Gonçalves, UFRJ

Médico Nefrologista do Serviço de Nefrologia do HUCFF; responsável pelo setor de Transplante Renal do Hospital Universitário Clementino Fraga Filho-HUCFF-UFRJ.

Marco Aurélio Martins, FIOCRUZ-RJ

Doutor em Biologia Celular e Molecular pela Fundação Oswaldo Cruz-Fiocruz. Pós-doutoramento no William Harvey Institute e Imperial College-Londres. Chefe do Laboratório de Inflamação do Instituto Oswaldo Cruz-Fiocruz-RJ.

Margareth Maria Gomes de Souza, UFRJ

Mestre e Doutora em Ortodontia pela UFRJ. Professora adjunto do departamento de Ortodontia da UFRJ.

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Published

2008-08-19

Issue

Vol. 24 No. 1 (2009)

Section

Literature Review

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