Mannose binding lectin genes (MBL2) polymorpshisms and the periodontal disease in diabetic patients

Natália Costa Araújo, Darcyla Maria de Aguiar Bello, Sergio Crovella, Paulo Roberto Eleutério de Souza, Nikos Donos, Renata Cimões


Purpose: To assess the association between the polymorphism in exon-1 of the MBL2 gene and the periodontal disease in type 2 diabetic patients.
Methods: The sample comprised of 100 patients, who were submitted to a clinical periodontal examination that evaluated in six sites per tooth the probing depth (PD), bleeding on probing (BOP), clinical attachment loss (CAL), plaque index (PI) and the number of teeth present. Periodontal disease was defined as at least four sites with loss of attachment of ≥5 mm, with one or more of those sites having a pocket of ≥ 4 mm. The collection of scaling cells from the oral mucosa was carried out and the detection of MBL2 polymorphism was made by real time PCR and melting temperature curve analysis.
Results: In a type 2 diabetic population, no significant statistical differences in MBL2 polymorphisms genotype or allele frequencies were observed among subjects with periodontal disease.
Conclusion: This study indicates that the polymorphisms in exon-1 of the MBL2 gene are not related to periodontal disease in a type 2 diabetic population.


Polymorphism; periodontitis; Diabetes Mellitus

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e-ISSN: 1980-6523

ISSN-L: 0102-9460


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