@article{Ulrich_Nogueira_Teixeira_Ely_Filho_Neto_2013, title={Early versus late-onset major depression in the elderly: a comparative study}, volume={1}, url={https://revistaseletronicas.pucrs.br/ojs/index.php/pajar/article/view/15790}, abstractNote={<p class="MsoNoSpacing" style="margin: 0cm 0cm 0pt;"><span style="font-size: small;"><span style="font-family: Calibri;"><em><span style="mso-ansi-language: EN-US;" lang="EN-US">Aims: </span></em><span style="mso-ansi-language: EN-US;" lang="EN-US">This study aims to investigate the distinctive characteristics between elderly with early-onset and late-onset major depression with respect to sociodemographic factors, self-perceived health, cardiovascular risk factors, MMSE scores, family history of depression, depressive symptoms, melancholic features, suicide risk and alcohol abuse/dependence. </span></span></span></p><p class="MsoNoSpacing" style="margin: 0cm 0cm 0pt;"><span style="font-size: small;"><span style="font-family: Calibri;"><em><span style="color: black; mso-ansi-language: EN-US; mso-bidi-font-family: ’Futura Md BT’;" lang="EN-US">Methods: </span></em><span style="color: black; mso-ansi-language: EN-US;" lang="EN-US">Cross-sectional, descriptive and analytic study, with prospective data collection, in an random sample of 348 elderly people (≥60 years old) of the Family Heath Strategy, of which were identified 90 cases of DSM-IV unipolar major depression; subjects were divided according to early or late (≥60) age at onset of depression. </span></span></span></p><p class="MsoNoSpacing" style="margin: 0cm 0cm 0pt;"><span style="font-size: small;"><span style="font-family: Calibri;"><em><span style="color: black; mso-ansi-language: EN-US; mso-bidi-font-family: ’Futura Md BT’;" lang="EN-US">Results: </span></em><span style="color: black; mso-ansi-language: EN-US;" lang="EN-US">The prevalence of major depression in the whole sample was 25.86%. The elderly subjects with depression were mainly of early-onset (69.14%) and female (74.4%); the mean age in years was higher in the late-onset major depression group (<em>p</em>=0.028); the groups did not differ with respect to the other factors; after multivariate analysis there was a trend toward a negative association between suicide risk and late-onset depression. </span></span></span></p><p class="MsoNoSpacing" style="margin: 0cm 0cm 0pt;"><span style="font-size: small;"><span style="font-family: Calibri;"><em><span style="color: black; mso-ansi-language: EN-US; mso-bidi-font-family: ’Futura Md BT’;" lang="EN-US">Conclusion: </span></em><span style="color: black; mso-ansi-language: EN-US;" lang="EN-US">The early or late age at onset of depressive symptoms was not associated with different profiles. The results of this paper give support to the hypothesis that early-and late-onset major depressive disorders are clinically undistinguishable and do not represent distinct pathologies or subtypes.</span></span></span></p><p align="left"> </p>}, number={1}, journal={PAJAR - Pan-American Journal of Aging Research}, author={Ulrich, Luiz Eduardo Flores and Nogueira, Eduardo Lopes and Teixeira, Laura Mocellin and Ely, Luísa Scheer and Filho, José Celestino Borges and Neto, Alfredo Cataldo}, year={2013}, month={nov.}, pages={8–15} }