Tissue inflammatory response to implantation of calcium hydroxide and iodoform in the back of rats

Authors

  • Raul Capp Pallotta
  • Manoel Eduardo de Lima Machado Universidade de São Paulo
  • Norair Salviano dos Reis Pontífica universidade Católica de Campinas
  • Guilherme Henrique Rosa Martins Associação de Santos e São Vicente
  • Cleber Keiti Nabeshima universidade de São Paulo

Keywords:

Calcium hydroxide, Endodontics, inflammation, iodoform

Abstract

Purpose: This study evaluated the inflammatory reaction caused by the implantation of iodoform and calcium hydroxide in the back of rats. These drugs may be used as intracanal dressings to eliminate residual bacteria of the root canal system. Methods: Twenty albinic rats (Rattus norvegicus, var Wistar) were divided into four groups: control group 1 (CG1) had normal skin; control group 2 (CG2) had wounded tissue without drugs; in groups 3 and 4, iodoform (IG) and calcium hydroxide (CHG) were inserted into the wounds, respectively. After 3, 5 and 11 days, slices of the implanted areas were macroscopically and microscopically observed regarding to their qualitative and quantitative aspects. Results: In the macroscopical analysis, the CHG showed a large area of necrosis and swelling, which progressively decreased; in the IG the presence of iodoform surrounded by normal tissue was observed. The qualitative and quantitative histological analysis showed that IG promoted a shorter delay in the inflammatory response than the CHG. Conclusion: The inflammatory reaction for iodoform had a peak period five days after the drug insertion. By comparison, calcium hydroxide showed a very large area of necrosis that could only be partially eliminated after eleven days.

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Published

2010-02-08

Issue

Vol. 25 No. 1 (2010)

Section

Original Article

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