Quantitative AgNORs study in ameloblastomas

Authors

  • Anna Corrêa Santos Universidade Federal de Pelotas
  • Sandra Beatriz Chaves Tarquinio Universidade Federal de Pelotas
  • Elena Riet Corrêa Rivero Universidade Federal de Santa Catarina
  • Lenita Maria Áver Araujo Universidade Federal de Pelotas
  • Cristina Iório Krause Universidade Federal de Pelotas

Keywords:

Ameloblastoma, AgNOR, cell proliferation, dentigerous cyst

Abstract

Purpose: Ameloblastomas are tumors that arise from the odontogenic epithelium, including the areas that coat the dentigerous cysts (DC). The aim of the present study was to investigate the proliferative activity present in luminal and mural areas of mural unicystic ameloblastomas (MUA), in conventional ameloblastomas (CA), and in DC, comparing them according to their biological behavior. Methods: AgNOR quantifications were performed using routine light microscopy under X100 magnification in 10 cases per type of lesion, considering 100 cells of representative areas of the tumor for each case. The AgNORs were observed as black dots within the cell nucleus. Results: MUA showed significant lower number of NORs/nucleus in the luminal proliferation area than in the area of mural proliferation and in CA (P<0.05). Conclusion: CA exhibit proliferative activity similar to the mural component of MUA, corroborating the pattern of higher aggressive clinical behavior of these tumor variants. Key words: Ameloblastoma; AgNOR; cell proliferation; dentigerous cyst

Author Biographies

Anna Corrêa Santos, Universidade Federal de Pelotas

Department of Semiology and Clinic, School of Dentistry, Federal University of Pelotas, Pelotas, RS, Brazil; Especialist in Periodontology –ABO

Sandra Beatriz Chaves Tarquinio, Universidade Federal de Pelotas

Associate Professor – DDS, MS, PhD - Department of Semiology and Clinic, School of Dentistry, Federal University of Pelotas, Pelotas, RS, Brazil

Elena Riet Corrêa Rivero, Universidade Federal de Santa Catarina

Associate Professor - DDS, MS, PhD Department of Pathology, Health Science Center, Federal University of Santa Catarina, Florianópolis, SC, Brazil

Lenita Maria Áver Araujo, Universidade Federal de Pelotas

Associate Professor – DDS, MS, PhD - Department of Semiology and Clinic, School of Dentistry, Federal University of Pelotas, Pelotas, RS, Brazil

Cristina Iório Krause, Universidade Federal de Pelotas

DDS, Department of Semiology and Clinic, School of Dentistry, Federal University of Pelotas, Pelotas, RS, Brazil

Downloads

Published

2008-11-22

Issue

Vol. 24 No. 1 (2009)

Section

Original Article

License

COPYRIGHT
The submission of originals to Odonto Ciência implies the transfer by the authors of the right for publication. Authors retain copyright and grant the journal right of first publication. If the authors wish to include the same data into another publication, they must cite Odonto Ciência as the site of original publication.

CREATIVE COMMONS LICENSE
As this journal is open access, the articles are allowed free use in scientific and educational applications, with citation of the source.
According to the type of Creative Commons License (CC-BY 4.0) adopted by Odonto Ciência, the user must respect the requirements below.

You are free to:
Share — copy and redistribute the material in any medium or format.
Adapt — remix, transform, and build upon the material for any purpose, even commercially.

However, only under the following terms:
Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests Odonto Ciência endorses you or your use.
No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

Notices:
You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation.
No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.

For more details on the Creative Commons license, please follow the link in the footer of this website.