Avaliação do D-dímero como preditor de gravidade, grau de envolvimento pulmonar e mortalidade em pacientes com COVID-19

Autores

DOI:

https://doi.org/10.15448/1980-6108.2022.1.43281

Palavras-chave:

COVID-19, D-dímero, Gravidade da doença, doença pulmonar, Mortalidade

Resumo

Objetivo: Verificar os valores do D-dímero para predizer a gravidade da doença, o grau de envolvimento pulmonar e a mortalidade em pacientes com COVID-19.
Método: Os níveis de dímero D de 200 pacientes confirmados com COVID-19 foram medidos, prospectivamente, no Departamento de Emergência do Hospital Razi de Ahvaz, no dia da admissão, e suas relações com a gravidade da doença, escore de tomografia computadorizada (CT) e mortalidade foram avaliadas. 
Resultados: Os níveis do D-dímero > 1,04 μg/mL e ≤ 1,12 μg/mL podem indicar doença grave e alto grau de envolvimento pulmonar, mas baixo risco de morte. A taxa de mortalidade nos pacientes com valor de D-dímero > 1,12 μg/mL foi significativamente maior do naqueles com nível de D-dímero ≤ 1,12 μg/mL (17,2% x 1,5%; P:0,02). Foi encontrada uma correlação positiva independente entre o D-dímero e o escore de CT de tórax e a gravidade da doença (OR: 1,84; IC 95%:1,38 - 2,45; P:0,0001). 
Conclusão: O nível do D-dímero > 1,12 μg/mL no estágio inicial da infecção por COVID-19 pode prever independentemente a doença grave, alto grau de envolvimento pulmonar e alto risco de morte, indicando seu papel benéfico no manejo oportuno de pacientes críticos.

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Biografia do Autor

Mofid Hosseinzadeh, Emergency Medicine Department, School of Medicine, Jundishapur University of Medical Sciences, Ahvaz, Iran.

MD-PhD in Emergency medicine from Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; assistant professor at the Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Mandana Pouladzadeh, Emergency Medicine Department, School of Medicine, Jundishapur University of Medical Sciences, Ahvaz, Iran.

MD-PhD in Emergency medicine from Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; assistant professor at the Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Amin Eftekhar, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Khuzestan, Iran.

Graduated MD student from Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Parastoo Moradi Choghakabodi, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Khuzestan, Iran.

DVM from Shahid Chamran University of Ahvaz (Jundi Shapur); MD Senior Clinical Investigator at Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Alireza Sokooti, Department of Pathology, Razi Hospital, School of Medicine, Ahvaz, Khuzestan, Iran.

MD-Phd of clinical pathology from Department of Pathology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; working at Razi Hospital

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Publicado

2022-10-05

Como Citar

Hosseinzadeh, M., Pouladzadeh, M., Eftekhar, A., Choghakabodi, P. M., & Sokooti, A. (2022). Avaliação do D-dímero como preditor de gravidade, grau de envolvimento pulmonar e mortalidade em pacientes com COVID-19. Scientia Medica, 32(1), e43281. https://doi.org/10.15448/1980-6108.2022.1.43281