Genética do envelhecimento e seu impacto sobre a longevidade humana: teorias e evidências para prevenção das doenças do envelhecimento

Autores

  • Ivana Beatrice Mânica da Cruz Federal University of Santa Maria

DOI:

https://doi.org/10.15448/2357-9641.2014.1.20082

Palavras-chave:

Genética. Longevidade. Envelhecimento.

Resumo

Estudos biogerontológicos sobre fatores que afetam a longevidade humana e o envelhecimento bem sucedido são altamente relevantes. Portanto, aqui eu reviso e comento algumas questões atuais sobre teoria do envelhecimento, a existência (ou não) de “genes da longevidade” e os principais mecanismos genéticos e epigenéticos que potencialmente estão envolvidos no envelhecimento e tempo de vida. A partir desta revisão eu também faço considerações sobre o impacto do ambiente na genética e epigenética que influencia a saúde e longevidade humana.

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Montano MA, da Cruz IB, Duarte MM, Krewer Cda C, da Rocha MI, Mânica-Cattani MF, Soares FA, Rosa G, Maris AF, Battiston FG, Trott A, Lera JP. Inflammatory cytokines in vitro production are associated with Ala16Val superoxide dismutase gene polymorphism of peripheral blood mononuclear cells. Cytokine. 2012;60(1):30-3.

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Maia Ribeiro EA, Ribeiro EE, Viegas K, Teixeira F, dos Santos Montagner GF, Mota KM, Barbisan F, da Cruz IB, de Paz JA. Functional, balance and health determinants of falls in a free living community Amazon riparian elderly. Arch Gerontol Geriatr. 2013;56(2):350-7.

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;53:119-25.

Hertz E, Cadoná FC, Machado AK, Azzolin V, Holmirch S, Assmann C, Ledur P, Ribeiro EE, Souza Filho OC, Manica- Cattani MF, Cruz IBM. Effect of Paullinia cupana on MCF‑7 breast cancer cell response to chemotherapeutic drugs. Mol Clin Oncology. 2015;3:37-43.

Krewer CC, Suleiman L, Duarte MMF, Ribeiro EE, Mostardeiro CP, Montano MAE, da Rocha MIU, Algarve TD, Bresciani GB, Cruz IBM. Guaraná, a supplement rich in caffeine and catechin, modulates cytokines: evidence from human in vitro and in vivo protocols. European Food Research and Technology 2014;239(1):49-57.

Jobim ML, Santos RC, dos Santos Alves CF, Oliveira RM, Mostardeiro CP, Sagrillo MR, de Souza Filho OC, Garcia LF, Manica-Cattani MF, Ribeiro EE, da Cruz IB. Antimicrobial activity of Amazon Astrocaryum aculeatum extracts and its association to oxidative metabolism. Microbiol Res.

;169(4):314-23.

de Souza Filho OC, Sagrillo MR, Garcia LF, Machado AK, Cadoná F, Ribeiro EE, Duarte MM, Morel AF, da Cruz IB. The in vitro genotoxic effect of Tucuma (Astrocaryum aculeatum), an Amazonian fruit rich in carotenoids. J Med Food. 2013;16(11):1013-21.

Sagrillo MC, Garcia LFM, Souza Filho OC, Duarte MMF, Ribeiro EE, Cadoná FC, Cruz IBM. Tucumã fruit extracts (Astrocaryum aculeatum Meyer) decrease cytotoxic effects of hydrogen peroxide on human lymphocytes. Food Chem, 2015 (in press).

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Publicado

2015-06-10

Como Citar

Cruz, I. B. M. da. (2015). Genética do envelhecimento e seu impacto sobre a longevidade humana: teorias e evidências para prevenção das doenças do envelhecimento. PAJAR - Pan-American Journal of Aging Research, 2(1), 3–14. https://doi.org/10.15448/2357-9641.2014.1.20082

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