Mannose binding lectin genes (MBL2) polymorpshisms and the periodontal disease in diabetic patients

  • Natália Costa Araújo Federal Univesity of Pernambuc
  • Darcyla Maria de Aguiar Bello Federal University of Pernambuco
  • Sergio Crovella Federal University of Pernambuco
  • Paulo Roberto Eleutério de Souza Federal Rural University of Pernambuco
  • Nikos Donos
  • Renata Cimões Federal University of Pernambuco
Keywords: Polymorphism, periodontitis, Diabetes Mellitus


Purpose: To assess the association between the polymorphism in exon-1 of the MBL2 gene and the periodontal disease in type 2 diabetic patients. Methods: The sample comprised of 100 patients, who were submitted to a clinical periodontal examination that evaluated in six sites per tooth the probing depth (PD), bleeding on probing (BOP), clinical attachment loss (CAL), plaque index (PI) and the number of teeth present. Periodontal disease was defined as at least four sites with loss of attachment of ≥5 mm, with one or more of those sites having a pocket of ≥ 4 mm. The collection of scaling cells from the oral mucosa was carried out and the detection of MBL2 polymorphism was made by real time PCR and melting temperature curve analysis. Results: In a type 2 diabetic population, no significant statistical differences in MBL2 polymorphisms genotype or allele frequencies were observed among subjects with periodontal disease. Conclusion: This study indicates that the polymorphisms in exon-1 of the MBL2 gene are not related to periodontal disease in a type 2 diabetic population.

Author Biographies

Nikos Donos
Dean of Periodontology Unit, Eastman Dental Hospital, University College London, London
Renata Cimões, Federal University of Pernambuco
Adjunct Professor, Prosthesis and Oral Facial Surgery, Federal University of Pernambuco
Original Article