Oral focal mucinosis: report of two cases

  • BS Manjunatha KM SHAH DENTAL COLLEGE & HOSPITAL
  • AS Madhusudhan
  • Das Nagarajappa
  • Saawarn Swati
  • HS Charan Babu
Keywords: Oral focal mucinosis, myxomatous lesion, cutaneous focal mucinosis, hyaluronic acid, focal myxoid degeneration

Abstract

Purpose: Oral focal mucinosis (OFM), an oral counterpart of cutaneous focal mucinosis, is a rare disease of unknown etiology. Its pathogenesis may be due to overproduction of hyaluronic acid by fibroblast at the expense of collagen production, resulting in focal myxoid degeneration of connective tissue primarily affecting the mucosa overlying bone. It has no distinctive clinical features, since the diagnosis is solely based on histopathological features. This paper reports two cases and discusses clinicopathological, immunohistochemical features and differential diagnosis of myxomatous lesions of the oral cavity. Case description: The two cases of OFM lesions were present in a 50 year-old patient on the hard palate and in a 26 year-old female patient in the mandible, which seem to be the first report in the Indian population. Conclusion: The histopathological and immunohistochemical analysis of Vimentin and S-100 protein may play a vital role in the correct diagnosis of OFM.

Author Biographies

BS Manjunatha, KM SHAH DENTAL COLLEGE & HOSPITAL
Department of Oral and Maxillofacial Pathology, KM Shah Dental College and Hospital, Pipariya, Vadodara, Rajastan State, India
AS Madhusudhan
Department of Oral and Maxillofacial Pathology, Pacific Dental College and Hospital, Debari, Udaipur, Rajastan State, India
Das Nagarajappa
Department of Oral and Maxillofacial Surgery, SJM Dental College and Hospital, Chitradurga, Karnataka State, India
Saawarn Swati
Department of Oral and Maxillofacial Pathology, Pacific Dental College and Hospital, Debari, Udaipur, Rajastan State, India
HS Charan Babu
Department of Oral and Maxillofacial Surgery, Pacific Dental College and Hospital, Debari, Udaipur, Rajastan State, India
Published
2010-09-25
Section
Case Report