Commercial swine model: an alternative for direct pulp capping studies

  • Antônio César Leites UFPel
  • Adriana Fernandes da Silva Universidade Federal de Pelotas
  • Sandra Beatriz Chaves Tarquinio UFPel
  • Flávio Fernando Demarco UFPel
  • Thomas Normanton Guim UFPel
  • Evandro Piva UFPel
Keywords: Animals, swine, primary dentition, dental pulp capping


Purpose: To test the use of commercial swine as an in vivo model for studying pulp healing in response to direct capping agents. Methods: Six swine sus scrofa domesticus (Landrace X Large White) were used in the experiment. Under anesthesia, class V cavities were prepared with a pulp exposure, which was directly capped with hard-setting calcium hydroxide (Dycal®, Dentsply, Petrópolis, Rio de Janeiro, Brazil). Restorations were performed with resin-modified glass ionomer cement (Vitremer® 3M Espe St Paul, MN, USA). After 7 or 70 days (n = 6), the animals were died; the teeth were extracted, formalin-fixed and prepared for histological evaluation. The biological response was categorized using the following criteria: inflammatory response, soft tissue organization, reactionary and, reparative dentin formations. Results: After seven days pulp in most specimens inflammatory response was present and after 70 days reparative dentin was formed at the pulp exposure area in almost all the animals. These responses were similar to those previously reported in human in similar periods of evaluation. In addition, the swine model showed another advantages: easy handling and economical feasibility compared to other animal models. Conclusion: The commercial swine model seems to be an adequate animal model to test pulp biocompatibility.

Author Biographies

Antônio César Leites, UFPel
Departamento de Morfologia do IB/UFPel
Adriana Fernandes da Silva, Universidade Federal de Pelotas
Departamento de Dentística Conservadora da FO/UFPel Dentística Restauradora
Sandra Beatriz Chaves Tarquinio, UFPel
Departamento de Semiologia e Diagnóstico Patologia Bucal
Flávio Fernando Demarco, UFPel
Departamento de Dentística Conservadora da FO/UFPel Dentística Restauradora
Thomas Normanton Guim, UFPel
Programa de Pós-Graduação em Medicina Veterinária Doutorando
Evandro Piva, UFPel
Departamento de Dentística Conservadora da FO/UFPel Dentística Restauradora
Original Article