Buccal Candida albicans of children with Dow's syndrome: behavior of germ tubes, exoenzimes and sensibility to killer toxins

  • Evandro Leão Ribeiro
  • Cerise de Castro Campos
  • Clever Gomes Cardoso
  • Wesley Magno Ferreira
  • Fabiana Cristina Pimenta
  • Orlando Ayrton de Toledo
Keywords: buccal candidiasis, Down’s syndrome


Based on the need of better understanding of the colonization and pathogenicity mechanisms for Candida yeasts coming of the buccal cavity of children with Down’s syndrome, the objective of this study of case control was to evaluate the capacity of production of germ tubes and exoenzymes (aspartil proteinases and phospholipases) for buccal C. albicans and the behavior front killer toxins. They were used 35 (87.5%) buccal C. albicans strains of children with Down’s syndrome and 05 (12.5%) of children without syndrome. The production sínof germ tubes and the exoenzymes detection and sensibility to killer toxins for Candida isolates were accomplished according to Reynolds-Braude, Ruchel, Prince and Polonelli et al. techniques respectively. The Reynolds-Braude test showed better capacity of induce the formation of germ tubes in the children group with Down’s syndrome. In both study and control gruops had the exoenzymes detection, however C. albicans strains of children with chromossomal alteration came more aspartil proteolitics and phospholipidolitics. Differences statistics were previously significant in relationship both biological capacities described (Reynolds-Braude test and exoenzymatic activity of Candida strains) (p < 0.05). Biotypical for killer toxins showed larger biotypes diversity in children with Down’s syndrome. It is ended that C. albicans strains originating of the buccal mucosa of children with Down’s syndrome presented in vitro a larger predisposition the colonization and the pathogenicity, besides a better phenotypic expressiveness in relation to killer toxins. UNITERMS: buccal candidiasis; Down’s syndrome
Original Article