Clinicopathologic features of ameloblastoma in southern Brazil: a 55-year single-center analysis

Authors

  • Ana Luisa Homem de Carvalho Pontifical Catholic University of Rio Grande do Sul
  • Manoela Domingues Martins Universidade Federal do Rio Grande do Sul
  • Francinne Miranda da Rosa Universidade Federal do Rio Grande do Sul
  • Annemarie Saudades Universidade Federal do Rio Grande do Sul
  • Manoel Sant´Ana Filho Universidade Federal do Rio Grande do Sul

DOI:

https://doi.org/10.15448/1980-6523.2016.1.15352

Keywords:

Odontogenic tumors, Ameloblastoma, Epidemiology

Abstract

Objective: Ameloblastoma is a benign odontogenic tumor (OT) originating from the proliferation of odontogenic epithelium without involvement of the mesenchymal tissue. The aims of the present study were to perform a retrospective analysis of ameloblastoma, compare the findings with those described in previous studies and outline the epidemiological profile of this type of tumor in southern Brazilian population.
Methods: Cases of ameloblastoma were retrieved between 1954 and 2009 from a single center and analyzed for age, gender, ethnic, primary site and histological type. Cases were classified according to the 2005 WHO classification of OTs.
Results: Descriptive statistical analysis of the data was performed, with the determination of the frequency of the categorical variables. Eighty-nine cases of ameloblastoma were found: 78 cases of solid tumor (88.6%), two cases of desmoplastic tumor (2.2%) and nine cases of the unicystic tumor (10.2%). There was a predominance of the female gender (58.4%) and Caucasian ethnicity (62.9%). Most ameloblastomas were located in the mandible (78.6%) and 40.2% occurred prior to the third decade of life.
Conclusion: The present findings are in agreement with those reported in previous studies carried out in other states of Brazil and support that notion that there may be a geographical influence on the profile of patients affected by ameloblastoma.

References

Sciubba JJ, Eversole LR, Slootweg PJ. WHO Pathology & Genetics Head and Neck Tumours. 2005;6:287-9.

Ghandhi D, Ayoub AF, Pogrel MA, MacDonald G, Brocklebank LM, Moos KF. Ameloblastoma: A Surgeon’s Dilemma. J Oral Maxillofac Surg. 2006;64:1010-1014.

Reichart PA, Philipsen HP, Sonner S. Ameloblastoma: a biological profile of 3677 cases. Eur J Cancer B Oral Oncol. 1995;31B(2): 86-99.

Hertog D, Bloemena E, Aartman IH, van der Waal, I. Histopathology of ameloblastomas of the Jans: some critical observations based on 40 years single institution experience.Med Oral Patol Oral Cir Bucal. 2012;17(1):e76-82.

Junquera L, Ascani G, García-Consuegra L, Vicente JC, Roig P. Ameloblastoma Revisited. Ann Otol Rhinol Laryngol. 2003;112:1034-9.

Pinheiro JJV, Freitas VM, Moretti AIS, Jorge AG, Jaeger RG. Local invasiveness of ameloblastoma: Role played by matrix metalloproteinases and proliferative activity. Histopathology. 2004;45:65-72.

Philipsen HP, Reichart PA.Unicystic ameloblastoma. A review of 193 cases from the literature. Oral Oncol. 1998;34:317-325.

Hertog D, van der Waal I. Ameloblastoma of the jaws: A critical reappraisal based on a 40-years single institution experience. Oral Oncology. 2010;46:61-4.

Barbachan JJD, Rados PV, Filho MS, Quadros OF. Considerações sobre ameloblastomas. R. Fac. Odont.1985;27:13-25.

Chidzonga MM, Lopez VM, Alverez AP. Odontogenic tumours: analysis of 148 cases in Zimbabwe. Cent Afr J Med. 1996;42:158-61.

Mosqueda-Taylor A, Ledesma-Montes C, Caballero-Sandoval S, Portilla-Robertson J, Ruíz-Godoy Rivera LM, Meneses-García A.Odontogenic tumors in Mexico: a collaborative retrospective study of 349 cases.Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1997;84:672-5.

Fernandes AM, Duarte ECB, Pimenta FJGS, Souza LN, Santos VR, Mesquita RA, Aguiar MCF. Odontogenic tumors: a study of 340 cases in a Brazilian population. J Oral Pathol Med. 2005;34:583-7.

Ledesma-Montes C, Mosqueda-Taylor A, Carlos-Bregni R, Romero de León E, Palma-Guzmán JM, Paéz-Valencia C, Meneses-García A. Ameloblastomas: a regional Latin-American multicentric study. Oral Diseases. 2007;13:303-7.

Adeline VL, Dimba EAO, Wakoli KA, Njiru AK, Awange DO, Onyango JF, Chindia ML. Clinicopathologic Features of Ameloblastoma in Kenya: A 10-Year Audit. The Journal of Craniofacialsurgery. 2008;19: 1589-93.

Tawfik MA, Zyada MM. Odontogenic tumors in Dakahlia, Egypt: analysis of 82 cases.Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;109:e67-73.

Fregnani ER, da Cruz Perez DE, de Almeida OP, Kowalski LP, Soares FA, de Abreu Alves F.Clinicopathological study and treatment outcomes of 121 cases of ameloblastomas.Int J Oral Maxillofac Surg. 2010;39: 145-9.

Fulco GM, Nonaka CFW, Souza LB, Miguel MCC, Pinto LP. Solid ameloblastomas – Retrospective clinical and histopathologic study of 54 cases. Braz J Otorhinolaryngol. 2010;76:172-7.

Krishnapillai R, Angadi PV. A clinical, radiographic, and histologic review of 73 cases of ameloblastoma in an Indian population. Quintessense Int. 2010;41:e90-e100.

Ledesma-Montes C, Ibarra-Villanueva A, Garce’s-Ortız M, Portilla-Robertson J. Ameloblastoma. Analysis of 338 cases. Med Oral. 2000;5:254-60.

Wu PC, Chan KW. A survey of tumors of the jawbones in Hong Kong Chinese: 1963–1982. Br J Oral Maxillofac Surg. 1985;23:92-102.

Lu Y, Xuan M, Takata T, Wang C, He Z, Zhou Z, Mock D, Nikai H. Odontogenic tumors: a demographic study of 759 cases in Chinese population. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998;86:707-14.

Odukoya O. Odontogenic tumors: analysis of 289 Nigerian cases. J Oral Pathol Med. 1995;24:454-7.

Daley TD, Wysocki GP, Pringle GA.Relative incidence of odontogenic tumors and oral and jaw cysts in a Canadian population.Oral Surg Oral Med Oral Pathol.1994;77:276-80.

IBGE,2008.http://www.ibge.gov.br/home/presidencia/noticias/noticia_visualiza.php?id_noticia=737.

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2016-11-17

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