Squamous cell carcinoma in proliferative verrucous leukoplakia: report of a case and review of the literature

  • Luciana Maria Pedreira Ramalho
  • Sílvia Regina Almeida Reis
  • Flávia Caló de Aquino
  • Caroline Góes
  • Lúcio F. T. Damis


Proliferative Verrucous Leukoplakia (PVL) is a premalignant lesion that shows an aggressive biological behavior and high risk of malignization then oral leukoplakias. The diagnosis is made by a combination of both clinical and microscopic findings and the follow up of suffers has to be rigorous involving the removal of risk factors such as tobacco and alcohol and follow-up biopsies can be carried out when changes in signs or symptoms occur. This study makes a review about PVL and reports a case of squamous cell carcinoma arising from a proliferative verrucous leukoplakia, empathizing both clinical and histopathological aspects as well as the importance of careful follow-up and complementary exams such as toluidine blue dye.
UNITERMS: oral leukoplakia; squamous cell carcinoma; neoplastic cell transformation; toluidine blue.
Case Report