The impact of chronic stress on behavior in rats with ligature-induced periodontal disease

  • Alessandra Nogueira Porto Universidade de Cuiabá-UNIC
  • Alex Semenoff Segundo Universidade de Cuiabá-UNIC
  • Álvaro Henrique Borges Universidade de Cuiabá-UNIC
  • Fábio Luis Miranda Pedro Universidade de Cuiabá-UNIC
  • Fernanda Zamol Matos School of Dentistry, UNIVAG
  • Tereza Aparecida Dele Vedove Semenoff Universidade de Cuiabá-UNIC
Keywords: stress, rats, periodontitis.

Abstract

 

Purpose: To evaluate the impact of chronic stress on behavior at different time points (7, 15 and 30 days) in rats with ligature-induced periodontal disease.

Methods: We selected 60 rats that were randomly divided into 2 groups: a stress group subjected to chronic stress by physical restraint one day after periodontitis induction (GE) and a control group (CG). After periods 10 animals from the GE group and 10 from the CG were analyzed in the open field and elevated plus-maze models.

Results: The results show that at 7 days, increased walk in the central segment of the apparatus and peripheral open field (

P<0.05) were observed in the GE group as well as increased instances of standing on two legs and self-cleaning (P<0.05). In the elevated plus-maze, no statistical differences were observed (P<0.05). At the 15-day time point, increased instances of standing on two legs and self-cleaning (P<0.05) were observed in the GE group. At 30 days, no behavioral differences were observed between the groups (P<0.05).

Conclusion: We conclude that stress affect the behavior of animals subjected to 7 and 15 days of chronic stress after the induction of periodontal disease by ligation.

Author Biography

Alessandra Nogueira Porto, Universidade de Cuiabá-UNIC
Doutora em Periodontia pela Universidade de Taubaté _UNITAU. Professora de Mestrado em ODontologia- UNIC.
Published
2012-11-19
Section
Original Article