Epithelial-myoepithelial carcinoma in the floor of mouth: case report and review of the literature
AbstractPurpose: to document the clinical, histopathological and immunohistochemical findings of an epithelial-myoepithelial carcinoma (EMC) in the floor of mouth with extension to the submandibular region. Furthermore, we intend to discuss the current literature about this tumor. Case description: the biphasic pattern of neoplastic cells could be confirmed by immunohistochemical analysis, which showed positivity for cytokeratin (CK7) in luminal cells and for α-smooth muscle actin (α-SMA) in those non-luminal. All of the features were consistent with the diagnostic criteria required for EMC and the patient was referred for specialized treatment. Conclusion: EMC is a rare type of malignant tumor, accounting for about 1% of all salivary gland tumors. Arising most frequently in the parotid gland (75%), approximately 10% of the tumors have their origin in the submandibular gland, and rarely affect the minor salivary glands. The diagnosis should be based on conventional light microscopy and confirmed by immunohistochemical analysis.
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