Relationship between periodontal disease and hyperlipidemia related to vascular events
DOI:
https://doi.org/10.15448/1980-6523.2016.4.22732Keywords:
Periodontal diseases, Heart diseases, HyperlipidemiasAbstract
INTRODUCTION: The association between oral health and vascular disease has been recently studied and it can be seen that periodontal disease can influence health at all. On the other hand, atherosclerosis is a progressive disease with accumulation of fibrotic and inflammatory elements resulting in endothelial lesions, and increase of incidence when associated to chronic inflammations. It is known the association between Porphyromonas gingivalis and heart diseases, as this microorganism has been found in atheroma plaques, as other periodontal pathogens.
OBJECTIVE: Search information in literature that confirms the relationship between periodontal disease and hyperlipidemia associated to vascular disease.
METHODS: For this article revision, an online search has been made in scientific libraries such as the Virtual Library in Health (BVS, Bireme); PubMed; Digital Brazilian Theses and Dissertations (BDTD) from 2000 to 2014, using as key words periodontal disease, vascular disease, hyperlipidemia.
CONCLUSION: It has been confirmed by some authors the relation between periodontal disease and hyperlipidemia, otherwise, some contradictory results due to risk factors such as age, food intake and social and cultural factors. Mechanisms in which these factors acts in this progression still have not been clear.
References
Ghizoni JS, Sant`Ana ACP, Taveira LAA et al. Doença periodontal como fator coadjuvante para o desenvolvimento do acidente vascular encefálico e arterosclerose. RFO. 2008;13(3):83-7. Disponível em http:// perguntaserespostas.com.br/seer/index.php/rfo/article/view/637/419.
Machiavelli JL, Pio S. Medicina periodontal: uma revisão de literatura odontológica. Odontologia clínico-cientifica. 2008 jan-mar;7(1):19-23.
Kreuger MRO, Matte EW, Prats RS, Diegoli NM. Relação entre doenças periodontais e cardiovasculares em cardiopatas assistidos na UNIVALIITAJAÍ(SC).[ monografia de conclusão de curso] [Internet]. UNIVALIITAJAÍ(SC);2008 [acesso em 2014 out 25].
Libby P, Ridker PM, Maseri A. Inflammation and Atherosclerosis. Circulation. 2002;105(1):1135-43.
Gottlieb MGV, Bonardi G, Moriguchi EH. Fisiopatologia e aspectos inflamatórios da aterosclerose. Scientia Medica. 2005;15(3):203-7.
Lusis AJ. Atherosclerosis. Nature international weekly journal of science. 2010 Sept 14;407(6801):233-41.
Van Leuven SI, Sankatsing RR, Vermeulen JN, Kastelein JJP, Reiss P, Stroes ESG. Atherosclerotic vascular disease in HIV: it is not just antiretroviral therapy that hurts the heart!. Current Opinion in HIV and AIDS. 2007,2: 324-31. https://doi.org/10.1097/COH.0b013e3281e38a98
Sattar N, McCarey DW, Capell H, McInnes IB. Explaining how “high-grade” systemic inflammation accelerates vascular risk in rheumatoid arthritis. Circulation. 2003;108:2957-63.
Van Leuven SI, Kastelein JJP, Stroes ES. The hidden epidemic behind chronic inflammatory disease: accelerated atherogenesis. Academic Medical Center. Disponível em: http://www.athero.org/commentaries/
comm490.asp
Van Leuven SI, Franssen R, Kastelein JJ, Levi M, Stroes ESG, Tak PP. Systemic Inflammation as a risk factor for atherothrombosis. Rheumatology. 2008;47:3-7.
Khovidhunkit W, Memon RA, Feingold KR, Grunfeld C. Infection and Inflammation-Induced Proatherogenic Changes of Lipoproteins. The Journal of Infections Diseases. 2000;181(3):S462-72.
Asanuma Y, Oeser A, Shintani AK, Turner E, Olsen N, Fazio S, Linton MF, Raggi P, Stein CM. Premature Coronary-Artery Atherosclerosis in Systemic Lupus Erythematosus. N Engl J Med. 2003;349(25):2407-15.
McMahon M, Hahn BH. Atherosclerosis and systemic lupus erythematosusmechanistic basic of the association. Current Opinion in Immunology. 2007;19:633-39. https://doi.org/10.1016/j.coi.2007.11.001
Smeeth L, Thomas SL, Hall AJ, Hubbard R, Farrington P, Vallance P. Risk of Myocardial Infarction and Stroke after Acute Infection or Vaccination. N Engl J Med. 2004;351(25):2611-8.
Rech RL, Nurkin N, Cruz I, Sostizzo F, Baião C, Perrone JA, Wainstein R, Pretto D, Manenti ERF, Bodanese LC. Association between periodontal disease and acute coronary syndrome. Arq Bras Cardiol. 2007;88(2):162-6.
Kreisner PE, Ferreira AGM, Heitz C, Woitchunas GFP, Martins CAM. Procedimento Cirúrgico em Pacientes que Fazem uso do Ácido Acetilsalicílico ou Anticoagulantes Orais. Rev da Facul Odont. 2003;8(1):22-7.
Filho PMS, Silva EA, Weksler C, Drable SG, Tura BR, Fonseca MG, Cunha AB, Fischer RG. Interferência da doença periodontal na anticoagulação oral em pacientes cardiopatas: efeito do tratamento periodontal na anticoagulação oral. Rev Port Cardiol. 2007;26(10):977-89.
Barilli ALA, Passos ADC, Marin-Neto JA, Franco LJ. Doenças periodontais em pacientes com doença isquêmica coronariana aterosclerótica, em Hospital Universitário. Arq Bras Cardiol. 2006;87(6):695-700.
Kinane DF, Lindhe J, Trombelli L. Periodontite crônica. In: Lindhe J, Lang NP, Karring T. 5ª ed. Rio de Janeiro: Guanabara Koogan; 2010. 402-9.
Buhlin K, Gustafsson A, Pockley AG, Frostegard J, Klinge B. Risk factors for cardiovascular disease in patients with periodontitis. European Heart Journal. 2003;24: 2099-107.
Belstrom D, Damgaard C, Nielsen CH, Holmstrup P. Does a causal relation between cardiovascular disease and periodontitis exist?. Microbes and Infection. 2012;14:411-8. https://doi.org/10.1016/j.micinf.2011.12.004
Kinane DF, Lowe GDO. How periodontal disease may contribute to cardiovascular disease. Periodontology. 2000;23:121-6. https://doi.
org/10.1034/j.1600-0757.2000.2230112.x
Machado ACP, Vadenal R, Cortelli JR. Doença periodontal e doença cardíaca: uma revisão dos mecanismos. Rev. Biociên. 2004;10(3):153-9.
Togashi AY, Gomes ADS, Foiato TF, Almeida RMS. Prevalência da doença periodontal em pacientes cardiopatas. Revista Varia Scientia. 2005;5(10):35-45.
Costa TD, Silva Junior GF, Terezan MLF. Influência das doenças periodontais sobre as cardiopatias coronariana. R. Ci. Méd. Biol. 2005;4(1):63-9.
Pierrakos C, Vicent JL. Sepsis biomarkers: a review. Crit Care. 2010;14(1):R15. https://doi.org/10.1186/cc8872
Tonetti MS, D'Aiuto F, Nibali L, Donald A, Storry C, Parkar M, Suvan J, Hingorani AD, Vallance P, Deanfield J. Treatment of Periodontitis and Endothelial Function. N Engl J Med. 2007;356:911-20.
Balan H. Do Cardio-Vascular and Periodontal Diseases Have a Close, Causal Relationship?. Rom. J. Intern. Med. 2010;48(2):121-9.
Angeli F, Verdecchia P, Pellegrino C, Pellegrino RG, Pellegrino G, Prosciutti L, Giannoni C, Cianetti S, Bentivoglio M. Association Between Periodontal Disease and Left Ventricle Mass in Essential Hypertension. Hypertension 2003;41:488-92. https://doi.org/10.1161/01.HYP.0000056525.17476.D7
Shanker J, Setty P, Arvind P, Nair J, Bhasker D, Balakrishna G, Kakkar VV. Relationship between Periodontal disease, Porphyromonas gigivalis, peripheral vascular resistance markers and Coronary Artery Disease in Asian Indians. Thrombosis Reseach.2013;132:e8-e14. https://doi. org/10.1016/j.thromres.2013.04.023
Maekawa T, Takahashi N, Tabeta K, Aoki Y, Miyashita H, Miyauchi S,Miyazawa H, Nakajima T, Yamazaki K. Chronic Oral infection with Porphyromonas gingivalis Accelerates Atheroma Formation by Shifting the Lipid Profile. Plos One. 2011;6(5):e20240.
Bahekar AA, Singh S, Saha S, Molnar J, Arora R. The prevalence and incidence of coronary heart disease in significantly increased in periodontitis: A meta-analyis. American heart Journal. 2007;154(5).
ttps:// doi.org/10.1016/j.ahj.2007.06.037
Rivera MF, Lee J-Y, Aneja M, Goswami V, Liu L, Velkso IM, Chukkapalli SS, Bhattacharyya I, Cheon H, Lucas AR, Kesavalu LN. Polymicrobial infection with Major Periodontal Pathogens Induced Periodontal Disease and Aortic Atherosclerosis in Hyperlipidemic ApoEnull Mice. Plos One. 2013;8(2):e57178. https://doi.org/10.1371/journal.pone.0057178
Paizan ML, Martin JFV. Associação entre doença periodontal, doença cardiovascular e hipertensão arterial. Rev Bras Hipertens. 2009;16(3):183-5.
Rocha RACP, Fernandes A, Lucas RSCC. Doenças Periodontais, Dieta e Disturbios Cardiovasculares em Idosos Não Institucionalizados em Campina Grande-PB. Pesq Bras Odontoped Clin Integr. 2005; 5,(2): 133-40.
Lüscher TF, Seo B, Bühler FR. Potencial Role of Endothelin in Hypertension Controversy on endothelin in hypertension. Hypertension 1993;21(6): 752-7.
Fentoglu O, Bozkurt FY. The Bi-Directional Relationship between Periodontal Disease and Hyperlipidemia. Eur J Dent. 2008;2:142-49.
Penumarthy S, Penmetsa GS, Mannem S. Assessment of serum levels of triglycerides, total cholesterol, high-density lipoprotein cholesterol, and low density lipoprotein cholesterol in periodontitis patients. J Indian Soc Periodontol. 2013;17(1):30-5.
Taleghani F, Shamaei M, Shamaei M. Association between Chronic Periodontitis and Serum Lipid Levels. Acta Medica iranica. 2010;48(1): 47-50.
Sposito AC. Emerging insights into hypertension and dyslipidaemia synergies. European Heart Journal Supplements. 2004;6(supplement G):G8-G12. https://doi.org/10.1016/j.ehjsup.2004.10.003
Wajed J, Ahmad Y, Durrington PN, Bruce IN. Prevention of cardiovascular disease in systemic lupus erythematosus-proposed guidelines for risk factor management. Rheumatology. 2004;43:7-12.
Van Leuven SI, Hezemans R, Levels JH, Snoek S, Stokkers PC, Hovingh GK, Kastelein JJP, Stroes ES, Groot E, Hommes DW. Enhanced atherogenesis and altered high density lipoprotein in patients with Crohn's disease. Journal of Lipid Research;48:2640-6.
Ansell BJ, Watson KE, Fogelman AM, Navab M, Fonarow GC. High-Density Lipoprotein Function. J Am Coll Cardiol. 2005;46(10):1792-8. https://doi.
org/10.1016/j.jacc.2005.06.080
Navab M, Anantharamaiah GM, Folgeman AM. The Role of High-Density Lipoprotein in Inflammation. Trends Cardiovasc Med. 2005;15:158-61. https://doi.org/10.1016/j.tcm.2005.05.008
Levi M, Van der Poll T, Büller HR. Bidirectional relation between inflammation and coagulation. Circulation. 2004;109:2698-704.
Wagner DD, Burger PC. Platelets in Inflammation and Thrombosis. Arterioscler Thromb Vasc Biol. 2003;23:2131-7.
Gawaz M, Langer H, May AE. Platelets in inflammation and atherogenesis [Internet]. The journal of Clinical Investigation. 2005;115(12):3378-84. https://doi.org/10.1172/JCI27196
Michelson AD, Barnard MR, Krueger LA, Valeri CR, Furman MI. Circulating monocyte-platelet aggregates are a more sensitive marker of in vivo platelet activation than platelet surface P-Selectin: Studies in baboons, human coronary intervention, and human acute myocardial infarction. Circulation. 2001;104:1533-7.
Freedman JE, Loscalzo J. Platelet-monocyte aggregates:bridging thrombosis and inflammation. Circulation. 2002;105:2130-2.
Pejcic A, Kesic L, Brkic Z, Pesic Z, Mirkovic D. Effect of Periodontal Treatment on Lipoproteins Levels in Plasma in Patients with Periodontitis. Southern Medical Journal. 2011;104(8):547-52.
Cutler CW, Shinedling EA, Nunn M, Jotwani R, Kim B-O, Nares S, Lacopino AM. Association Between Periodontitis and Hyperlipidemia: Cause or Effect?. J Periodontol. 1999;70(12):1429-34. https://doi.org/10.1902/jop.1999.70.12.1429
Katz J, Flugelman MY, Goldberg A, Helf M. Association Between Periodontal Pockets and Elevated Cholesterol and Low Density Lipoprotein Cholesterol Levels. J Periodontol. 2002;73(5):494-500. https:// doi.org/10.1902/jop.2002.73.5.494
Oliveira FJ, Vieira RW, Coelho OR, Petrucci O, Oliveira PPM, Antunes N, Oliveira IPF, Antunes E. Inflamação sistêmica causada pela periodontite crônica em pacientes vítimas de ataque cardíaco isquêmico agudo. Rev Bras Cir Cardiovasc. 2010;25(1):51-8.
Hagh LG, Zakavi F, Hajizadeh F, Saleki M. The Association Between Hyperlipidemia and Periodontal Infection. Iran Red Crescent Med J. 2014;16(12):e6577. https://doi.org/10.5812/ircmj.6577
Machado ACP, Quirino MRS, Nascimento LFC. Relation between chronic periodontal disease and plasmatic levels of triglycerides, total cholesterol and fractions. Braz Oral Res. 2005;19(4):284-9. Lösche W, Karapetow F, Pohl A, Pohl C, Kocher T. Plasma lipid and bood glucose levels in patients with destructive periodontal disease. J Clin Periodontol. 2000;27: 537-41.
https://doi.org/10.1034/j.1600-051x.2000.027008537.x
Lei L, Li H, Yan F, Xiao Y. Hyperlipidemia Impaired Innate Immune Response to Periodontal Pathogen Porphyromonas gingivalis in Apolipoprotein E Konockout Mice. Plos one. 2013;(Issue8):e71849.
Eckel RH, Krauss RM. American Heart Association Call to Action: Obesity as a Major Risk Factor for Coronary Heart Disease. Circulation. 1998;97:2099-100.
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