Histological analysis of experimental wound healing under the action of low power laser [Abstract in English]<\b>

Jesus Antonio de Carvalho Abreu, Aline da Luz Sousa, Carmen Laís Gervásio Fônseca Alves, Jefferson Torres Nunes

Abstract


Aims: To assess histologically the healing of experimental skin wounds in Rattus norvergicus using low-power laser.
Methods: Forty-five males were divided into three groups according to the adopted therapy (untreated, treated with laser at a dose of 4 J/cm2 and treated with laser at a dose of 8 J/cm2), which were divided into three subgroups according to time of euthanasia (7, 14 and 21 days). A fragment of 2 cm in diameter of skin was removed from the back of each animal, and laser was irradiated every 24 hours in the fragments of the treated groups, with the previously established dose.
Results: At seven days after the experiment, the low-power laser irradiated groups showed a more efficient reepithelialization when compared with the untreated group. Furthermore, the groups treated with laser showed a more marked deposition of collagen at 14 days. Dose adjusted in 4 J/cm2 was more effective.
Conclusions: Low-power laser has enhanced the healing of experimental skin wounds in Rattus norvergicus. The adjusted dose in 4 J/cm2 was more effective.

Keywords


WOUND HEALING; SKIN/injuries; SKIN/anatomy & histology; MODELS, ANIMAL; ANIMAL EXPERIMENTATION; LASER THERAPY, LOW-LEVEL; RATS.



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