Male fertility preservation in oncology: patients’ profile and clinical guidance importance

Karin Vasconcelos de Carvalho, Fernanda Maria Wolff Baldi, Daniel Rodrigo Marinowic, Marta Ribeiro Hentschke, Cláudio Telöken, Álvaro Petracco, Mariangela Badalotti


AIMS: To evaluate the profile of men with cancer who performed semen cryopreservation prior/during treatment and address the importance of this method for reproductive health.
METHODS: This was a transversal and retrospective study which used a database from a Reproductive Medicine Center located in Brazil. A total of 150 male patients who performed semen cryopreservation due to cancer diagnosis, from January 2014 to December 2017, were included.
RESULTS: The profile of men seeking fertility preservation prior/during treatment for cancer was young adults, single, childless, with higher education. Oncologists were the ones who reported more patients for semen cryopreservation followed by urologists and hematologists. With regards to tumor diagnosis frequency, testicular was the most diagnosed, followed by Hodgkin’s/non-Hodgkin’s lymphoma, leukemia, prostate and rectal tumor, along with retroperitoneal tumor.
CONCLUSION: Data brought the reflection on the cultural and financial barriers involved for the accomplishment of cryopreservation. Health professionals attending cancer patients should consider the importance of educational and incentive activities to prevent male fertility. Future research on the subject should carried out.


Male fertility; fertility preservation; cryopreservation; neoplasms; reproductive age.

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Instituto Nacional do Câncer – INCA. Estimativa 2016: Incidência de câncer no brasil. [Internet]. São Paulo; 2016. [Updated 2019 Aug; cited 2016 Sept. 10]. Available from:

Loren AW, Mangu PB, Beck LN, Brennan L, Magdalinski AJ, Partridge AH, Quinn G, Wallace WH, Oktay K; American Society of Clinical Oncology. Fertility preservation for patients with cancer: American Society of Clinical Oncology clinical practice guideline update. J Clin Oncol. 2013;31(19):2500-10.

Tournaye H, Dohle GR, Barratt CL. Fertility preservation in men with cancer. Lancet. 2014;384(9950):1295-1301.

Jungwirth A, Giwercman A, Tournaye H, Diemer T, Kopa Z, Dohle G, Krausz C; European Association of Urology Working Group on Male Infertility. European Association of Urology guidelines on Male Infertility: the 2012 update. Eur Urol. 2012;62(2): 324-32. Epub 2012 May 3.

Hourvitz A, Goldschlag DE, Davis OK, Gosden LV, Palermo GD, Rosenwaks Z. Intracytoplasmic sperm injection (ICSI) using cryopreserved sperm from men with malignant neoplasm yields high pregnancy rates. Fertil Steril. 2008;90(3):557-63. Epub 2008 Aug 9.

Instituto Brasileiro de Geografia e Estatistica - IBGE. Censo demográfico 2010: características gerais da população, religião e pessoas com deficiência. Rio de Janeiro: Ministério do Planejamento, Orçamento e Gestão; 2010 [cited 2019 Ago 26]. Available from:

Alvarenga C, Cardoso AP, Cocuzza M, Srougi M. Preservação da fertilidade em homens jovens com câncer: conceitos atuais e o futuro/Fertility preservation in young men with cancer: current concepts and future. Rev Med (São Paulo). 2012; 91(3):223-8.

Furtado MH, Rodrigues JK, Marinho RM. Preservação da fertilidade em homens. In: Marinho RM, Silva ACJS, Caetano JPJ, Rodrigues JK, editors. Preservação da Fertilidade: uma nova fronteira em medicina e oncologia. 1st ed. Medbook; 2015. p. 107-136.

Avelar CC, Melamed RMM. Criopreservação oncológica e criopreservação social. In: Straube K, Melamed RMM. Temas contemporâneos de psicologia em reprodução humana assistida: a infertilidade em seu espectro psicoemocional. 2nd ed. São Paulo: Livrus; 2015. p. 57-76.

Lee SJ, Schover LR, Partridge AH, Patrizio P, Wallace WH, Hagerty K, Beck LN, Brennan LV, Oktay K; American Society of Clinical Oncology. American Society of Clinical Oncology recommendations on fertility preservation in cancer patients. J Clin Oncol. 2006;24(18):2917-2931.

Ribeiro, RA, Ferrari, BL, Duarte, RC. Pacientes com câncer e a fertilidade: o papel do oncologista: recomendações da ASCO. In: Marinho RM, Silva ACJS, Caetano JPJ, Rodrigues JK, editors. Preservação da Fertilidade: uma nova fronteira em medicina e oncologia. 1st ed. Rio de Janeiro: Medbook; 2015. p. 13-20.


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