Anal lesion caused by human papillomavirus in a woman living with HIV/AIDS

Vanessa Laís Diefenthäler, Mariele do Amaral Schneider Cardoso, Janice de Fátima Pavan Zanella, Paulo Ricardo Moreira, Janaina Coser

Abstract


*** Anal lesion caused by human papillomavirus in a woman living with HIV/AIDS ***

AIMS: To describe a case of anal lesion caused by human papillomavirus (HPV) infection in a woman living with HIV/AIDS.

CASE DESCRIPTION: A 35-year-old woman, diagnosed with HIV five years ago, reported pruritus ani, anal bleeding, painful defecation, and presence of small warts in the perianal region. The patient was seen at a specialized care center and was subjected to clinical examination with visual inspection, which revealed perianal condyloma. Histopathological examination confirmed the presence of moderate to severe dysplasia associated with HPV-compatible changes. The anal lesion was excised. At the onset of the symptoms, the patient was not on antiretroviral therapy and her HIV viral load was at its highest (2,951 copies/mL) compared with her previous laboratory tests. She had gone through emotional stress and presented with recurrent genital herpes simplex virus infections. These factors may have predisposed her to the development of anal condyloma.

CONCLUSIONS: Since HIV infection may alter the history of HPV infection, it is important that screening strategies include cytological analysis of both the cervix and the anal region.

Keywords


Papillomavirus infections; HIV infections; anus neoplasms.

References


Barcellos LN, Passos MAT. Carcinoma epidermoide perineal extenso em paciente HIV positivo: relato de caso. Rev Saúde. 2016;07(1):42-5. https://doi.org/10.21727/rs.v7i1.90

Sardinha R, Brás F, Ribeiro V, Pacheco A. HIV and HPV infection – clinical relevance Infecção VIH e HPV – importância clínica. Acta Obstet Ginecol Port. 2015;9(3):241-9.

García-Espinosa B, Moro-Rodríguez E, Álvarez-Fernández, E. Human papillomavirus genotypes in human immunodeficiency virus-positive patients with anal pathology in Madrid, Spain. Diagn Pathol. 2013;8(204):2-9. https://doi.org/10.1186/1746-1596-8-204

Aguiar MTM, Bosso NCC, Leal CBQS, Lira CF, Cabral LAO, Silva AMTC, Saddi VA. Clinicopathological aspects and prevalence of human papillomavirus in anal cancer. J Coloproctol. 2014;34(2):76-82. https://doi.org/10.1016/j.jcol.2014.03.004

Aguiar C, Jaumandreu S, Santín CA, Álvarez MCR, Ortega C. Lesiones rectoanales por VPH, diagnóstico mediante PAP anal y anoscopía de alta resolución con biopsias. Rev Méd Urug. 2015;31(2):97-102.

Manzione TS, Nadal SR, Calore EE, Nadal LRM, Manzione CR. Controle local da infecção perianal pelo papilomavirus humano após a erradicação dos condilomas acuminados. Rev Col Bras Cir. 2014;41(2):87-91. https://doi.org/10.1590/S0100-69912014000200003

Gonçalves PH, Montezuma-Rusca JM, Yarchoan R, Uldrick TS. Cancer prevention in HIV-infected populations. Semin Oncol. 2016;43:173-88. https://doi.org/10.1053/j.seminoncol.2015.09.011

Brasil. Ministério da Saúde. Boletim Epidemiológico HIV/AIDS – 2016 [Internet]. Brasília; 2016 [updated 2016 Jun; cited 2017 March]. Available from: http://www.aids.gov.br/pagina/boletim-epidemiologico

Martins APB, Brenda S, Dal Molin DB, Mendes GA. Soroprevalência de doenças infecciosas em doadores de sangue do Hemocentro Regional de Cruz Alta- Rio Grande do Sul. Clin Biomed Res. 2015;35(4):211-6. https://doi.org/10.4322/2357-9730.58832

Costa MJSM, Linhares MSC, Melo MGBA, Fernandes MM. Atenção Secundária à Saúde no Atendimento de DST e HIV/aids: Relato de Experiência. SANARE. 2016;15(1):132-8.

United States of America. Centers for Disease Control and Pevention. HPV - Associated Anal Cancer Rates by Race and Ethnicity [Internet]. Atlanta; 2016 [updated 2016 Jul; cited 2017 March]. Available from: https://www.cdc.gov/cancer/hpv/statistics/anal.htm

Betancourt EM, Wahbah MM, Been LC, Chiao EY, Citron DR, Laucirica R. Anal Cytology as a Predictor of Anal Intraepithelial Neoplasia in HIV-Positive Men and Women. Diagn Cytopathol. 2013;41(8)697-702. https://doi.org/10.1002/dc.22941

Giaccio CMRS, Bragaglia PL, Calore EE, Manzione CR, Nadal SR. Frequência de alterações citológicas anais em pacientes com citologia cervical normal. Diagn Tratamento. 2013;18(1):5-9.

Adler DH, Wallace M, Bennie T, Abar B, Meiring TL, Williamson AL, Bekker LG. Cumulative Impact of HIV and Multiple Concurrent Human Papillomavirus Infections on the Risk of Cervical Dysplasia. Adv Virol. 2016;2016:7310894. https://doi.org/10.1155/2016/7310894

Herranz-Pinto P, Sendagorta-Cudós E, Serna JIB, Rivera JMPS. Carcinoma anal e infección por el virus de la inmunodeficiencia humana: ¿es la hora del cribado?. Rev Clin Esp. 2014;214(2):87-93. https://doi.org/10.1016/j.rce.2013.08.011

Tso FK, Rodrigues CLL, Levi JE, Ferraz MGMC, Speck NMG, Ribalta JCL. HPV infection-associated anogenital cyto-colpo-histological findings and molecular typing in HIV-positive women. Genet Mol Res. 2015;14(4):17630-40. https://doi.org/10.4238/2015.December.21.36

Cambou MC, Luz PM, Lake JE, Levi JE, Coutinho JR, Andrade A, Heinke T, Derrico M, Veloso VG, Friedman RK, Grinsztejn B. Anal Human Papillomavirus (HPV) Prevalences and Factors Associated with Abnormal Anal Cytology in HIV-Infected Women in an Urban Cohort from Rio de Janeiro, Brazil. AIDS Patient Care and STDs. 2015;29(10):4-12. https://doi.org/10.1089/apc.2014.0166

Rocha-Brischiliari SC, Gimenes F, Abreu ALP, Irie MMT, Souza RP, Santana MG, Gravena AAF, Carvalho MDB, Consolaro MEL, Pelloso SM. Risk factors for cervical HPV infection and genotypes distribution in HIV-infected South Brazilian women. Infect Agent Cancer. 2014 Feb 11;9(1):6. https://doi.org/10.1186/1750-9378-9-6

Brasil. Ministério da Saúde. Protocolo Clínico e Diretrizes Terapêuticas para Manejo da Infecção pelo HIV em Adultos [Internet]. Brasília; 2015 [updated 2015 Jul; cited 2017 March]. Available from: http://www.aids.gov.br/pcdt

Padilla-Espa-a L, Repiso-Jiménez B, Fernández-Sánchez F, Frieyro-Elicegui M, Fernández-Morano T, Pereda T, Rivas-Ruiz F, Redondo M, Martín MT. Utilidad de la detección del virus del papiloma humano en el cribadode neoplasia intraepitelial anal en pacientes con conductas de riesgo. Enferm Infecc Microbiol Clin. 2014 Nov;32(9):560-4. https://doi.org/10.1016/j.eimc.2014.03.008




DOI: http://dx.doi.org/10.15448/1980-6108.2017.3.27017

 

***************************************************************************************************************

From 2011 (when it was indexed in Scopus), Scientia Medica features the Scimago Journal & Country Rank (SJR) impact factor.

SCImago Journal & Country Rank



 This journal is a member of, and subscribes to the principles of, the Committee on Publication Ethics (COPE) http://www.publicationethics.org

 

Licença Creative Commons
Except where otherwise noted, content of this journal is licensed under a Creative Commons Attribution 4.0 International license.


Editorial Policies of Brazilian Scientific Journals. Deposit availability: Blue .

Copyright: © 2006-2017 EDIPUCRS