Incidence of hospitalizations due to adverse drug events in Minas Gerais, Brazil

Yasmin de Oliveira Machado Silva, Marina Guimarães Lima


DOI: 10.15448/1980-6108.2017.1.24936

Aims: To estimate the rate of hospital admissions due to adverse drug events under the Unified Public Health System in the State of Minas Gerais, Brazil, according to demographic variables, length of stay, medical specialty, and cause of hospitalization.

Methods: Cross-sectional study with secondary data on hospital admissions paid for under the Unified Health System in Minas Gerais between 2012 and 2014. The incidence of hospitalizations for adverse drug events was calculated and expressed per 1,000 admissions. The total number of admissions and of hospitalizations for adverse drug events was described according to the patient’s gender and age, length of hospital stay, and the medical specialty. The frequencies of the different categories of the variables of interest were compared using the chi-square test and a 5% significance level.

Results: The incidence of hospitalizations for adverse drug events was 25.9 per 1,000 admissions paid for by the Unified Public Health System. Men had a higher rate of hospitalizations for adverse drug events than women (2.7% vs. 2.4%). In terms of age, the highest rate of hospitalizations for adverse drug events was observed among individuals aged 60 years or older (3.4%) and the lowest rate was among children aged up to 9 years (0.6%). A higher rate of hospitalizations for adverse drug events was observed when the length of stay was 15 days or longer (7.6%) and in patients admitted from the psychiatric service (8.3%).

Conclusions: Adverse drug events were an important cause of hospitalization under the Unified Public Health System in Minas Gerais between 2012 and 2014. Hospitalization for adverse drug events was associated with being male, being 60 years or older, having a longer hospital stay, and being admitted from the psychiatric service. Actions that promote pharmacovigilance in health institutions are necessary for the prevention of adverse drug events.


public health surveillance; pharmacovigilance; drug-related side effects and adverse reactions.


Carvalho WS, Moreira AM, Magalhães SMS. Eventos adversos a medicamentos. In: Acurcio FA, organizador. Medicamentos: políticas, assistência farmacêutica, farmacoepidemiologia e farmacoeconomia. Belo Horizonte: COOPMED; 2013. p. 147-78.

Organização Mundial da Saúde. Departamento de Medicamentos Essenciais e Outros Medicamentos. A importância da farmacovigilância: monitorização da segurança dos medicamentos. Brasília: Organização Pan-Americana da Saúde; 2005.

Capucho HC, Carvalho FD, Cassiani SHB. Farmacovigilância: gerenciamento de riscos da terapia medicamentosa para a segurança do paciente. São Paulo: Yendis; 2012.

Rozenfeld S. Agravos provocados por medicamentos em hospitais do Estado do Rio de Janeiro, Brasil. Rev Saúde Pública. 2007;41(1):108-15.

Varallo FR, Guimarães SOP, Abjaude SAR, Mastroianni PC. Causes for the underreporting of adverse drug events by health professionals: a systematic review. Rev Esc Enferm USP. 2014;48(4):739-47.

Mastroianni PC, Varallo FR, Barg MS, Noto AR, Galduróz JCF. Contribuição do uso de medicamentos para a admissão hospitalar. Braz J Pharm Sci. 2009;45(1):163-70.

Varallo FR, Costa MA, Mastroianni PC. Potenciais interações medicamentosas responsáveis por internações hospitalares. Rev Ciênc Farm Básica Apl. 2013;34(1):79-85.

Lobo MGAA, Pinheiro SMB, Castro JGD, Momenté VG, Pranchevicius M-CS. Adverse drug reaction monitoring: support for pharmacovigilance at a tertiary care hospital in Northern Brazil. BMC Pharmacol Toxicol. 2013;14:5.

Porto S, Martins M, Mendes W, Travassos C. A magnitude financeira dos eventos adversos em hospitais no Brasil. Rev Port Saúde Pública. 2010;Vol Temat (10):74-80.

Paula TC, Bochner R, Montilla DER. Análise clínica e epidemiológica das internações hospitalares de idosos decorrentes de intoxicações e efeitos adversos de medicamentos, Brasil, de 2004 a 2008. Rev Bras Epidemiol. 2012;15(4):828-44.

Giordani F, Rozenfeld S, Martins M. Adverse drug events identified by triggers at a teaching hospital in Brazil. BMC Pharmacol Toxicol. 2014;15:71.

Mendes W, Martins M, Rozenfeld S, Travassos C. The assessment of adverse events in hospitals in Brazil. Int J Qual Health Care. 2009;21(4):279-84.

Mastroianni PC, Varallo FR, Hernandes CD. Brazilian regulation in pharmacovigilance: a review. Pharm Regul Aff. 2016;5:164.


e-ISSN: 1980-6108 | ISSN-L: 1806-5562

Except where otherwise specified, material published in this journal is licensed under a Creative Commons Attribution 4.0 International license, which allows unrestricted use, distribution and reproduction in any medium, provided the original publication is correctly cited.